Lactate concentration differences in plasma, whole blood, capillary finger blood and erythrocytes during submaximal graded exercise in humans
Abstract
The aim of the study was to investigate the distribution of lactate in plasma, whole blood, erythrocytes, and capillary finger blood, before and during submaximal exercise. Ten healthy male subjects performed submaximal graded cycle ergometer exercise for 20-25 min. Venous blood samples and capillary finger blood samples were taken before exercise and every 5th min during exercise for lactate determination. The plasma lactate concentration was significantly higher (P less than 0.001, approximately 50%) than in the erythrocytes. This difference was not altered by the venous blood lactate concentration or exercise intensity. A significant difference (P less than 0.01) in lactate concentration was also found between capillary whole blood and venous whole blood. It was concluded that direct comparisons between lactate in capillary finger blood, venous whole blood and plasma could not be made.
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A category-ratio perceived exertion scale
Noble, B. J., Borg, G. A. V., Jacobs, I. A., Ceci, R. L., & KAISER, P. (1983) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198315060-00015 · Cited by 627 · see citing works
Plasma lactate accumulation and distance running performance
Farrell, P. A., Wilmore, J. H., Coyle, E. F., BILLING, J. E., & COSTILL, D. L. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199310000-00002 · Cited by 539 · see citing works
Onset of Blood Lactate Accumulation and Marathon Running Performance
Sjödin, B., & Jacobs, I. A. (1981) · International Journal of Sports Medicine · doi:10.1055/s-2008-1034579 · Cited by 519 · see citing works
Self-citationApplied Physiology of Marathon Running
Sjödin, B., & Svedenhag, J. (1985) · Sports Medicine · doi:10.2165/00007256-198502020-00002 · Cited by 317 · see citing works
Self-citationPlasma lactate accumulation and distance running performance
FARRELL, P. A., WILMORE, J. H., COYLE, E. F., BILLING, J. E., & COSTILL, D. L. (1979) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-197901140-00005 · Cited by 279 · see citing works
Ten kilometer performance and predicted velocity at V02max among well-trained male runners
Morgan, D. W., Baldini, F. D., Martin, P. E., & Kohrt, W. M. (1989) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198902000-00014 · Cited by 240 · see citing works
Disposal of blood [1-13c] lactate in humans during rest and exercise
Mazzeo, R. S., Brooks, G. A., Schoeller, D. A., & Budinger, T. F. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.1.232 · Cited by 189 · see citing works
Blood lactate threshold in some well-trained ischemic heart disease patients
Coyle, E. F., Martin, W. H., Ehsani, A. A., Hagberg, J. M., Bloomfield, S. A., Sinacore, D. R., & Holloszy, J. O. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.54.1.18 · Cited by 177 · see citing works
Relationships of the anaerobic threshold with the 5 km, 10 km, and 10 mile races
Kumagai, S., Tanaka, K., Matsuura, Y., Matsuzaka, A., Hirakoba, K., & Asano, K. (1982) · European Journal of Applied Physiology · doi:10.1007/bf00428959 · Cited by 159 · see citing works
Disposal of lactate during and after strenuous exercise in humans
Astrand, P. O., Hultman, E., Juhlin-Dannfelt, A., & Reynolds, G. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.1.338 · Cited by 129 · see citing works
Some physiological demands of a half-marathon race on recreational runners.
Williams, C., & Nute, M. L. (1983) · British Journal of Sports Medicine · doi:10.1136/bjsm.17.3.152 · Cited by 76 · see citing works
Lactate uptake by inactive forearm during progressive leg exercise
POORTMANS, J. R., Bossche, J. D.-V., & Leclercq, R. (1978) · Journal of Applied Physiology · doi:10.1152/jappl.1978.45.6.835 · Cited by 69 · see citing works
Intraerythrocyte and plasma lactate concentrations during exercise in humans
Buono, M. J., & Yeager, J. E. (1986) · European Journal of Applied Physiology · doi:10.1007/bf02343807 · Cited by 51 · see citing works
Exercise alters the distribution of ammonia and lactate in blood
Harris, R. T., & Dudley, G. A. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.1.313 · Cited by 47 · see citing works
Arterial versus venous blood lactate increase in the forearm during incremental bicycle exercise
Yoshida, T., Takeuchi, N., & Suda, Y. (1982) · European Journal of Applied Physiology · doi:10.1007/bf00952247 · Cited by 43 · see citing works
BLOOD AS A PHYSICOCHEMICAL SYSTEM
Johnson, R. E., Edwards, H. T., Dill, D. B., et al. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51082-6 · Cited by 36 · see citing works
Validation of a semi-automated technique for measuring lactate in whole blood.
Weil, M. H., Leavy, J. A., Rackow, E. C., et al. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.12.2175 · Cited by 36 · see citing works
Lactate and pyruvate gradients between red blood cells and plasma during acute asphyxia
Daniel, S. S., Morishima, H. O., James, L. S., et al. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.6.1100 · Cited by 31 · see citing works
"Stat" measurements of L-lactate in whole blood and cerebrospinal fluid assessed.
Wandrup, J. H., Tvede, K., Grinsted, J., et al. (1989) · Clinical Chemistry · doi:10.1093/clinchem/35.8.1740 · Cited by 29 · see citing works
THE DISTRIBUTION OF LACTIC ACID IN HUMAN BLOOD
Decker, D. G., & Rosenbaum, J. D. (1942) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1942.138.1.7 · Cited by 14 · see citing works
Role of the Metabolites in the Acid-Base Balance During Exercise1
de Coster, A., Dénolin, H., Messin, R., et al. (2015) · Medicine and sport science/Medicine and sport · doi:10.1159/000387212 · Cited by 12 · see citing works
DISTRIBUTION OF LACTATE BETWEEN THE CORPUSCLES AND THE PLASMA IN BLOOD
Devadatta, S. C. (1934) · Quarterly journal of experimental physiology · doi:10.1113/expphysiol.1934.sp000650 · Cited by 6 · see citing works
Neue enzymatische Lactatbestimmung: Methodische Aspekte und Probengewinnung
Schwab, W. G., Tritschler, W., Kessler, A. C., et al. (1979) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1979.17.2.65 · Cited by 3 · see citing works
Schwab, W. G., Tritschler, W., Kessler, A. C., et al. (1979) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Hollman W (1961) Zur Frage der Dauerleistungsfähigkeit. Fortschr Med 17:439?446
- Noble BJ, Borg G, Jacobs I, Ceci R, Kaiser P (1983) A categoryratio perceived exertion scale: relationship to blood lactate and muscle lactate and heart rate. Med Sci Sport Exerc 15:523?528
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- Authors
- Foxdal, P., Sj�din, B., Rudstam, H., �stman, C., �stman, B., & Hedenstierna, G. C.
- Affiliations
- Uppsala University Hospital (SE)
- Venue
- European Journal of Applied Physiology and Occupational Physiology
- Published
- 1990-10
- Volume
- 61
- Issue
- 3-4
- Pages
- 218-222
- ISSN
- 0020-9376 (ISSN-L)
- 0301-5548
- 1439-6327
- OpenAlex
- W1988641126
- Semantic Scholar
- 230d7ece735d03b99450876a513b00070e07acd8
- Cited by
- 108
- References
- 24
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- lactate, plasma lactate, whole blood lactate, erythrocytes, submaximal exercise, graded exercise, cycle ergometry, venous blood
- MeSH terms
- Capillaries, Erythrocytes, Fingers, Humans, Lactates, Male, Plasma, Veins, Exercise, Lactic Acid
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