Cross tolerance between LSD and psilocybin

Isbell, Harris; Wolbach, A. B.; Wikler, A.; Miner, E. J.

doi:10.1007/bf00407974

Cited by 137Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorAlkaloids: synthesis and pharmacology

Cross tolerance between LSD and psilocybin

Isbell, Harris, Wolbach, A. B., Wikler, A., Miner, E. J.·1961·Psychopharmacologia

DOI 10.1007/bf00407974

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Psychedelics do not lead to addiction in humans, and the rapid tolerance effects that follow psychedelic administration further limits their abuse potential.
“Furthermore, although some addictive potential has been demonstrated for classical and non-classical psychedelics on rat models (161), psychedelics do not lead to addiction in humans (162), and the rapid tolerance effects that follow psychedelic administration further limits their abuse potential (163, 164).”
From Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy (2021) · cites this paper as [163]

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Bioactive Alkaloids from Fungi: Psilocybin
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INTERACTIONS OF HALLUCINOGENS AT THE CLINICAL LEVEL
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Self-citation
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Self-citation
A comparison of LSD-25 with (?)-?9-trans-tetrahydrocannabinol (THC) and attempted cross tolerance between LSD and THC
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Self-citation

Authors: Isbell, H., Wolbach, A. B., Wikler, A., & Miner, E. J.
Affiliations: United States Public Health Service (US)
Venue: Psychopharmacologia
Publisher: Springer Science and Business Media LLC
Published: 1961
Volume: 2
Issue: 3
Pages: 147-159
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00407974
OpenAlex: W2019004642
Cited by: 137
References: 14
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 9 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 10.41
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
Keywords: cross-tolerance, LSD, psilocybin, chronic drug administration, psychedelics
MeSH terms: Hallucinogens, Indoles, Lysergic Acid Diethylamide, Psilocybin

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