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Cited by 72Sleep and related disordersSleep and Wakefulness ResearchSleep and Work-Related Fatigue

A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs

Vogel, Gerald W., Barker, Katherine, Gibbons, Pauline, Thurmond, Arthur·1976·Psychopharmacology
DOI 10.1007/bf00428706
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Abstract

The effects of oral, bedtime triazolam 0.5 mg and flurazepam 30 mg, on the laboratory sleep of 12 insomniacs were compared in a double blind, crossover study. A 22 consecutive night schedule was used: Nts. 1--2 placebo; 3--6 first drug; 7--8 placebo; 9--14 no drugs; 15--16 placebo; 17--20 second drug; 21--22 placebo. In 6 Ss first drug was triazolam and second drug was flurazepam. In the other 6 Ss the drug order was reversed. Effects on sleep were assessed objectively by conventional EEG/EOG/EMG sleep recordings and subjectively by questionnaires administered each morning. Side or toxic effects were assessed by physical exams, clinical lab tests, and twice daily questionnaires. During their administration the two drugs were practically indistinguishable in their effects. Both significantly reduced objective and subjective measures of insomnia, such as total wake time and sleep latency. On discontinuation the drugs differentially affected sleep, e.g., on the first post flurazepam night total sleep time was significantly more than baseline whereas on first post triazolam night, total sleep time was significantly less than baseline. There were no remarkable side or toxic effects with either drug.

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Authors
Vogel, G. W., Barker, K., Gibbons, P., & Thurmond, A.
Affiliations
Emory University (US)
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1976
Volume
47
Issue
1
Pages
81-86
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf00428706
OpenAlex
W2068751246
Cited by
72
References
13
Citations by year
2020: 1 · 2017: 1 · 2014: 1
FWCI
2.81
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
flurazepam, triazolam, insomnia, hypnotics, sleep latency, total sleep time, wake time, adverse drug reactions, benzodiazepines
MeSH terms
Adult, Clinical Trials as Topic, Female, Flurazepam, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Sleep, Sleep Stages, Anti-Anxiety Agents

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