Dopaminergic supersensitivity after neuroleptics: time-course and specificity
Abstract
It is known that a single dose of a neuroleptic can elicit dopaminergic supersensitivity in animals. On the other hand, the clinical syndrome of tardive dyskinesia takes many months of years to develop. To resolve this apparent discrepancy, it is possible that subclinical or latent tardive dyskinesia is fully compensated in most patients taking neuroleptics. In others, where the tardive dyskinesia is full-blown and grossly apparent, the dopaminergic supersensitivity may be decompensated. Such compensatory and decompensatory phases have been proposed earlier by Hornykiewicz (1974), in the case of Parkinson's Disease. Dopaminergic supersensitivity persists for a period proportional to the lenght of the neuroleptic treatment. It is not yet clear whether the relation between the length of treatment and the persistence of supersensitivity holds for very long treatments, but in principle the relationship might account for the persistence of tardive dyskinesia after years of neuroleptic pretreatment.
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- Authors
- Muller, P., & Seeman, P.
- Affiliations
- University of Toronto (CA)
- ORCID
- Seeman, Philip
- Venue
- Psychopharmacology
- Published
- 1978
- Volume
- 60
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1972190053
- Cited by
- 271
- References
- 78
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2013: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopaminergic supersensitivity, antipsychotic drugs, tardive dyskinesia, compensatory mechanisms, decompensation, dopamine receptors, antipsychotic adverse effects
- MeSH terms
- Animals, Dopamine, Dyskinesia, Drug-Induced, Humans, Synaptic Transmission, Receptors, Dopamine, Time Factors, Antipsychotic Agents
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