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Cited by 114Schizophrenia research and treatmentElectroconvulsive Therapy StudiesNeurotransmitter Receptor Influence on Behavior

Tardive dyskinesia: are first signs reversible?

F M Quitkin, Arthur E. Rifkin, L Gochfeld, Donald F. Klein·1977·American Journal of Psychiatry
DOI 10.1176/ajp.134.1.84
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Abstract

Although tardive dyskinesia, a serious and sometimes irreversible side effect of antipsychotic drug use, is becoming increasingly common, there is still considerable confusion concerning the course of the syndrome. The authors observed 12 psychiatric patients with tardive dyskinesia from the inception of the syndrome. They found that first symptoms rarely persisted if antipsychotics were discontinued and concluded that the length of time symptoms have persisted prior to drug discontinuation, not age at onset, may be the major variable determining reversibility of the syndrome.

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Crossref · 10.1176/ajp.134.1.84

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  • There is likely considerable interindividual variability in the tapering process, with patients able to tolerate greatly varying rates of reduction; some long-term treated patients may need longer periods, and some first-episode patients or those treated for briefer periods may tolerate shorter tapering periods.

    “There is likely to be considerable interindividual variability in this process, with patients able to tolerate greatly varying rates of reduction: given the data on time for TD to resolve, some long-term treated patients may need longer periods, and some first-episode patients or those treated for briefer periods may tolerate shorter tapering periods.75,76,78,101”

    From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [101]

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Related

Authors
Quitkin, F. M., Rifkin, A. E., Gochfeld, L., & Klein, D. F.
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1977-01-01
Volume
134
Issue
1
Pages
84-87
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.134.1.84
OpenAlex
W2414414545
Cited by
114
References
16
Citations by year
2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2014: 1
FWCI
16.68
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
tardive dyskinesia, antipsychotic adverse effects, reversibility, antipsychotic discontinuation, symptom duration, age of onset, psychiatric patients
MeSH terms
Adult, Chlorpromazine, Dyskinesia, Drug-Induced, Female, Fluphenazine, Haloperidol, Humans, Male, Middle Aged, Prognosis, Remission, Spontaneous, Antipsychotic Agents

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