Cited by 30Pain Management and Placebo EffectDental Anxiety and Anesthesia TechniquesStress Responses and Cortisol

Hypnotic analgesia in conditions of stress is partially reversed by naloxone

Frid, M., Singer, G.·1979·Psychopharmacology

Abstract

In this study the hypothesis that hypnotic analgesia under conditions of stress is mediated through a neurochemical mechanism involving the release of opioid peptides in the CNS was investigated. Ten highly hypnotizable subjects participated in a 2 x 2 factorial design, which involved hypnotic analgesia, stress and double blind administration of naloxone (an opiate antagonist) or placebo. Analysis of post-hypnosis results indicates that hypnotic analgesia was significantly reversed by the interactive effects of stress and naloxone. It is inferred that stress may be the common psychological denominator of the various analgesic methods which effectively engage this endogenous pain inhibitory system. Additional analyses of anxiety measures reveals no significant association between trait and state anxiety, but significant relationships between state anxiety and time tolerance to ischemic pain. These results suggest that anxiety remains a definitional problem and that previous conceptualizations may not have satisfactorily explained the affect's adaptive function.

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Authors
Frid, M., & Singer, G.
Affiliations
La Trobe University (AU)
Venue
Psychopharmacology
Published
1979
Volume
63
Issue
3
Pages
211-215
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2057129007
Cited by
30
References
25
Citations by year
2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2013: 2
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Dentistry › Oral Surgery › Dental Anxiety and Anesthesia Techniques
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
hypnotic analgesia, stress, naloxone, opioid peptides, hypnotic susceptibility, state anxiety, opioid antagonists
MeSH terms
Adult, Anxiety, Female, Humans, Hypnosis, Anesthetic, Male, Memory, Naloxone, Pain, Stress, Psychological

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