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Cited by 111Amyotrophic Lateral Sclerosis ResearchAluminum toxicity and tolerance in plants and animalsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys

Garruto, R. M., Shankar, S. K., Yanagihara, R., Salazar, A. M., Amyx, H. L., Gajdusek, D. C.·1989·Acta Neuropathologica
DOI 10.1007/bf00688211
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Abstract

Long-term epidemiological studies indicate that environmental factors play a causative role in high-incidence amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the western Pacific. An increased risk for disease is acquired in youth and remains for life. The low concentrations of calcium and magnesium and high levels of aluminum in the soil and drinking water, along with the relative isolation of these populations, constitute an unusual environmental feature common to all three high-incidence foci. Studies of mineral deposition in brain tissue of Guamanian ALS and PD patients, as well as of neurologically normal Guamanians with neurofibrillary degeneration, demonstrate accumulations of calcium, aluminum and silicon in neurofibrillary tangle-bearing neurons. In an attempt to duplicate the low calcium and high aluminum and manganese in soil and drinking water in these foci, we maintained juvenile cynomolgus monkeys for 41 to 46 months on a low-calcium diet with or without supplemental aluminum and manganese. Experimental animals exhibited mild calcium and aluminum deposition and degenerative changes, compatible with those of early ALS and PD, in motor neurons of the spinal cord, brain stem, substantia nigra and cerebrum. Neuropathological findings included chromatolysis, aberrant perikaryal accumulation of phosphorylated neurofilament, neurofibrillary tangles, axonal spheroids, and basophilic and hyaline-like inclusions consisting of abnormal cytoskeletal elements by electron microscopy. The magnitude and extent of these lesions far exceeded those found in normal aged monkeys.

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Crossref · 10.1007/bf00688211

Cites

34 of 34 references verified0 citation errors · 0 not checkable

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  • Garruto et al. reported that cynomolgus monkeys fed a low calcium diet with Al had more degenerative changes consistent with early Alzheimer's disease or Parkinson's dementia in the central nervous system than control monkeys.

    “Garruto et al. (1989) reported that cynomolgus monkeys fed a low calcium diet (3,200 mg/kg diet) with Al (125 mg/day) for 41 to 46 months had more degenerative changes that were consistent with early Alzheimer’s disease or Parkinson’s dementia in the central nervous system than control monkeys.”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Garruto et al. (1989)

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1 of the 35 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. Chou SM (1979) Pathognomy of intraneuronal inclusions in ALS. In: Tsubaki T, Toyokura Y (eds) Amyotrophic lateral sclerosis. University of Tokyo Press, Tokyo, pp 135?176
  2. Gajdusck DC (1984) Environmental factors provoking physiological changes which induced motor neuron disease and early neuronal aging in high-incidence foci in the western Pacific: calcium deficiency-induced secondary hyperparathyroidism and resultant CNS deposition of calcium and other metallic cations as the cause of ALS and PD in high-incidence foci. In: Rose FC (ed) Progress in motor neuron disease. Pitman Books, Tunbridge Wells, pp 44?69
  3. Iwata S, Sasajima K, Yase Y, Chen K-M (1978) Report of investigation of the environmental factors related to occurrence of amyotrophic lateral sclerosis in Guam Island. Japanese Ministry of Education, Tokyo, Japan
  4. Linton RW, Bryan SR, Cox XB, Griffis DP, Shelburne JD, Fiori CE, Garruto RM (1987) Digital imaging studies of aluminum and calcium in neurofibrillary tangle-bearing neurons using SIMS (secondary ion mass spectrometry). Trace Elements Med 4:99?104
  5. Polsky RI, Nunn PB, Bell EA (1972) Distribution and toxicity of ?-amino-?-methylaminopropionic acid. Fed Proc 31:1473?1475
  6. Sieber SM, Correa P, Dalgard DW, McIntire KR, Adamson RH (1980) Carcinogenicity and hepatoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates. J Natl Cancer Inst 65:177?189
  7. Yase Y (1978) The basic process of amyotrophic lateral sclerosis as reflected in the Kii Peninsula and Guam. In: den Hartog Jager WA, Bruyn GW, Heijstee APJ (eds) Proceedings of the Eleventh World Congress of Neurology, Amsterdam, Netherlands, September 11?16, 1977. International Congress Series No. 434. Excerpta Medica, Amsterdam, pp 413?427
  8. Yase Y (1980) The role of aluminum in CNS degeneration with interaction of calcium. Neurotoxicology 1:101?109

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Metadata

Authors
Garruto, R. M., Shankar, S. K., Yanagihara, R., Salazar, A. M., Amyx, H. L., & Gajdusek, D. C.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
1989
Volume
78
Issue
2
Pages
210-219
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
DOI
10.1007/bf00688211
OpenAlex
W2068548289
Cited by
111
References
35
Citations by year
2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2017: 8 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
7.33
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
amyotrophic lateral sclerosis, parkinsonism-dementia complex, low calcium diet, aluminum, manganese, environmental risk factors, motor neuron degeneration, neurofibrillary tangles, calcium deposition, substantia nigra, Macaca fascicularis, neuropathology
MeSH terms
Aluminum, Amyotrophic Lateral Sclerosis, Animals, Brain Stem, Calcium, Dietary, Diet, Intermediate Filaments, Macaca fascicularis, Motor Neurons, Spinal Cord, Manganese Poisoning

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