Glucose control of basal insulin secretion in diabetes
Open accessAbstract
The plasma insulin response to both a small increase and decrease in the plasma glucose has been studied in normal and diabetic, non-obese subjects. In a second investigation the plasma insulin concentrations were measured during a gradual reduction of the raised fasting plasma glucose of diabetes to normal levels. In both studies, diabetic patients were found to have a markedly impaired response of the fasting plasma insulin to small changes in plasma glucose. These results do not support the suggestion that stimulated and not basal insulin secretion is impaired in diabetes. Both modes of secretion are probably via the same B-cell release mechanism, which is deficient in diabetes. There was a gradation of response between maturity onset and juvenile onset diabetics.
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Fasting plasma insulin concentration is largely determined by the glucose concentration.
“The fasting plasma insulin concentration is largely determined by the glucose concentration [3]”
From Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man (1985) · cites this paper as [3]
The Results and Discussion (page unavailable in our copy) show that changing plasma glucose affects basal insulin secretion. But they also report markedly impaired responses in diabetic subjects, including cases where insulin remained nearly constant despite a substantial glucose decrease. The paper therefore supports glucose as an influence, but not the unqualified claim that it largely determines fasting insulin concentration. (LLM, conf=0.84)
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Cites
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- Authors
- McCarthy, S. T., Harris, E., & Turner, R. C.
- Affiliations
- University of Oxford (GB)
- Venue
- Diabetologia
- Published
- 1977-04
- Volume
- 13
- Issue
- 2
- Pages
- 93-97
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2009011154
- Cited by
- 18
- References
- 16
- Citations by year
- 2019: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- basal insulin secretion, glycemic control, diabetes mellitus, fasting insulin, insulin response to glucose, beta-cell dysfunction, maturity-onset diabetes, type 1 diabetes, type 2 diabetes
- MeSH terms
- Insulin Secretion, Aged, Blood Glucose, Diabetes Mellitus, Humans, Insulin, Male, Middle Aged
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