The mitochondrial megachannel is the permeability transition pore

Ionic channels of excitable membranes

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Mechanisms by which mitochondria transport calcium

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Role of calcium ions in regulation of mammalian intramitochondrial metabolism

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Ionic channels of excitable membranes

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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

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The Ca2+-induced membrane transition in mitochondria

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Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

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Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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Mitochondrial calcium transport

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The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

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Action of cyclosporine on mitochondrial calcium fluxes

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Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress: A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload

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Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

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The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

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Mitochondrial channel activity studied by patch-clamping mitoplasts

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Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants.

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Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

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Evidence for the existence of an inner membrane anion channel in mitochondria

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The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage

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Stimulation of mitochondrial calcium ion efflux by thiol-specific reagents and by thyroxine. The relationship to adenosine diphosphate retention and to mitochondrial permeability

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Calcium modulation of mitochondrial inner membrane channel activity

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Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms

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Further investigation on the high-conductance ion channel of the inner membrane of mitochondria

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Adenine nucleotide transport during cardiac ischemia

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Effect of ADP/ATP antiporter conformational state on the suppression of the nonspecific permeability of the inner mitochondrial membrane by cyclosporine A

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Selective effect of inhibitors on inner mitochondrial membrane channels

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The K+ conductance of the inner mitochondrial membrane. A study of the inducible uniport for monovalent cations

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Intramitochondrial adenine nucleotides and energy-linked functions of heart mitochondria

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Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,535

Oxidative stress and apoptosis

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Transient and Long-Lasting Openings of the Mitochondrial Permeability Transition Pore Can Be Monitored Directly in Intact Cells by Changes in Mitochondrial Calcein Fluorescence

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The mitochondrial permeability transition from in vitro artifact to disease target

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An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore

Alavian, K. N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H.-A., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401591111 · Cited by 592