The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore
Open accessAbstract
Significance: Stressful cellular events cause intracellular Ca 2+ dysregulation, rapid loss of inner mitochondrial membrane potential [the permeability transition (PT)], metabolic dysfunction, and death. Rapid Ca 2+ -induced uncoupling is one of the most important regulators of cell demise. We show that the c-subunit ring of the F 1 F O ATP synthase forms a voltage-sensitive channel, the persistent opening of which leads to PT and cell death. In contrast, c-subunit channel closure promotes cell survival and increased efficiency of cellular metabolism. The c-subunit channel is therefore strategically located at the center of the energy-producing complex of the cell to regulate metabolic efficiency and orchestrate the rapid onset of death and thus is a candidate for the mitochondrial PT pore.
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Cites
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · cited 1×
“The mPTP is sensitive not only to high levels of intramatrix Ca, but also to the protein CypD (22, 23), possibly by its binding to OSCP on the F1 stator, and to CsA, which may interfere with the CypD–OSCP interaction (10, 15, 21).”
BackgroundThe ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., & Wallace, D. C. (2004) · Nature · doi:10.1038/nature02229 · Cited by 1,086
HüSER, J., & BLATTER, L. A. (1999) · Biochemical Journal · doi:10.1042/bj3430311 · Cited by 266 · cited 1×
“Biochim Biophys Acta 1797(6-7):1124–1129.”
Cited by
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 961
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
Cadenas, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.024 · Cited by 820
Metadata
- Authors
- Alavian, K. N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H.-A., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M., Porter, G. A., & Jonas, E. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-16
- Volume
- 111
- Issue
- 29
- Pages
- 10580-10585
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052737683
- Cited by
- 592
- References
- 5
- FWCI
- 26.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Alavian, K. N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H.-A., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M., Porter, G. A., & Jonas, E. A. (2014). An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1401591111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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