Regulation of protein synthesis by mRNA structure
Abstract
In addition to the m7G cap structure, the length of the 5' UTR and the position and context of the AUG initiator codon (which have been discussed elsewhere in this volume), higher order structures within mRNA represent a critical parameter for translation. The role of RNA structure in translation initiation will be considered primarily, although structural elements have also been found to affect translation elongation and termination. We will first describe the different effects of higher order RNA structures per se, and then consider specific examples of RNA structural elements which control translation initiation by providing binding sites for regulatory proteins.
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A hairpin situated not far from a cap with a free energy of −30 to 50 kcal/mol may be sufficient to block access of the 43S preinitiation complex and inhibit translation.
“A hairpin situated not far from a cap with a free energy of −30 to 50 kcal/mol may be sufficient for blocking the access of the 43S preinitiation complex (which scans the 5′UTR to reach the start codon) and for inhibition of translation [47,48].”
From Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA (2023) · cites this paper as [47]
Cites
Iron regulates ferritin mRNA translation through a segment of its 5′-untranslated region.
Aziz, N., & Munro, H. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8478 · Cited by 368 · see citing works
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An evolutionarily conserved mechanism for controlling the efficiency of protein translation
Tuller, T., Carmi, A., Vestsigian, K., Navon, S., Dorfan, Y., Zaborske, J., Pan, T., Dahan, O., Furman, I., & Pilpel, Y. (2010) · Cell · doi:10.1016/j.cell.2010.03.031 · Cited by 874 · see citing works
Gray, N. K., & Hentze, M. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06699.x · Cited by 276 · see citing works
Self-citationMorrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0326 · Cited by 27 · see citing works
Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA
Kirshina, A., Vasileva, O., Kunyk, D., Seregina, K., Muslimov, A., Ivanov, R., & Reshetnikov, V. (2023) · Biomolecules · doi:10.3390/biom13111677 · Cited by 26 · see citing works
- Authors
- Gray, N. K., & Hentze, M. W.
- Affiliations
- European Molecular Biology Laboratory (DE)
- ORCID
- Gray, Nicola K.
- Venue
- Molecular Biology Reports
- Published
- 1994-05
- Volume
- 19
- Issue
- 3
- Pages
- 195-200
- ISSN
- 0301-4851 (ISSN-L)
- 1573-4978
- OpenAlex
- W2002664542
- Cited by
- 114
- References
- 1
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 11
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Biology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- mRNA secondary structure, translation initiation, translation elongation, translation termination, ribosome binding site, translational regulation, mRNA cap, 5' untranslated region
- MeSH terms
- Binding Sites, Humans, Nucleic Acid Conformation, Peptide Chain Initiation, Translational, Protein Binding, Proteins, RNA Caps, RNA, Messenger, Protein Biosynthesis, Codon, Initiator
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