Specificity of a milk clotting enzyme extracted from the thistleCynara cardunculus L.: Action on oxidised insulin and k-casein
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That enzyme induces milk coagulation through cleavage of the Phe105-Met106 bond in bovine κ-casein.
“Flowers of C. cardunculus were claimed to contain one acid proteinase with two glycosylated sub-units, with molecular masses of 31 and 16 kg .mol -1 ; that enzyme was found to induce milk coagulation through cleavage of the Phe 105 -Met 106 bond in bovine κ-casein [20].”
From Advances in the role of a plant coagulant ( <i>Cynara cardunculus</i> ) in vitro and during ripening of cheeses from several milk species (2002) · cites this paper as [20]
Flowers of C. cardunculus contain one acid proteinase with two glycosylated sub-units, with molecular masses of 31 and 16 kg.mol-1.
“Flowers of C. cardunculus were claimed to contain one acid proteinase with two glycosylated sub-units, with molecular masses of 31 and 16 kg .mol -1 ; that enzyme was found to induce milk coagulation through cleavage of the Phe 105 -Met 106 bond in bovine κ-casein [20].”
From Advances in the role of a plant coagulant ( <i>Cynara cardunculus</i> ) in vitro and during ripening of cheeses from several milk species (2002) · cites this paper as [20]
Extracts of C. cardunculus hydrolyse the insulin B-chain at the carboxylic side of the peptide bond of Phe-X, Leu-X and Ile-X, where X is preferentially Val or Tyr; however, the specificity is not entirely determined by the nature of the residues since Leu11-Val12 of the insulin B-chain was not cleaved.
“Extracts of C. cardunculus were reported to hydrolyse the insulin B-chain at the carboxylic side of the peptide bond of Phe-X, Leu-X and Ile-X, where X was preferentially Val or Tyr; however, the specificity was not entirely determined by the nature of the residues since Leu 11 -Val 12 of the insulin B-chain was not cleaved [20].”
From Advances in the role of a plant coagulant ( <i>Cynara cardunculus</i> ) in vitro and during ripening of cheeses from several milk species (2002) · cites this paper as [20]
Cited by
Sorted by citations
Roseiro, L. B., Barbosa, M., Ames, J. M., & Wilbey, R. A. (2003) · International Journal of Dairy Technology · doi:10.1046/j.1471-0307.2003.00080.x · Cited by 200 · see citing works
Veríssimo, P., Faro, C., Moir, A. J. G., Lin, Y., Tang, J., & Pires, E. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00762.x · Cited by 153 · see citing works
Self-citationVer�ssimo, P., Esteves, C., Faro, C., & Pires, E. (1995) · Biotechnology Letters · doi:10.1007/bf00129389 · Cited by 148 · see citing works
Self-citationBiochemistry of Cheese Ripening: Proteolysis
Ardö, Y., McSweeney, P. L. H., Magboul, A. A. A., Upadhyay, V. K., & Fox, P. F. (2017) · Cheese · doi:10.1016/b978-0-12-417012-4.00018-1 · Cited by 121 · see citing works
Sousa, M. J., & Malcata, F. X. (2002) · Le Lait · doi:10.1051/lait:2002001 · Cited by 84 · see citing works
Macedo, I. Q., Faro, C. J., & Pires, E. M. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00034a001 · Cited by 75 · see citing works
Self-citationCardoon-Based Rennets for Cheese Production
Almeida, C. M., & Simões, I. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9032-3 · Cited by 61 · see citing works
Hydrolysis of α-lactalbumin by cardosin A immobilized on highly activated supports
Barros, R. M., Extremina, C. I., Gonçalves, I. C., Braga, B. O., Balcão, V. M., & Malcata, F. X. (2003) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(03)00244-8 · Cited by 35 · see citing works
- Authors
- Faro, C. J., Moir, A. J. G., & Pires, E. V.
- Affiliations
- University of Coimbra (PT)
- University of Sheffield (GB)
- Venue
- Biotechnology Letters
- Published
- 1992-09
- Volume
- 14
- Issue
- 9
- Pages
- 841-846
- ISSN
- 0141-5492 (ISSN-L)
- 1573-6776
- OpenAlex
- W2074239169
- Cited by
- 56
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biotechnology Letters (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Cynara cardunculus studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pineapple and bromelain studies
- Keywords
- Cynara cardunculus, thistle, milk-clotting enzyme, aspartic protease, protease specificity, k-casein, insulin B chain, proteolytic cleavage sites, proteolytic fragments
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