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Clearance concepts in pharmacokinetics
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Research works printed but not linked: 11
- M. Rowland. Influence of route of administration on drug availability.J. Pharm. Sci. 61: 70–74 (1972). · DOI
- S. A. Cucinell and W. Perl. Application of clearance and volume of distribution to the plateau principle of drugs.J. Pharm. Sci. 59: 1423–1427 (1970). · DOI
- C. Von Bahr, B. Alexanderson, D. L. Azarnoff, F. Sjoquist, and S. Orrenius. A comparative study of drug metabolism in the isolated perfused liver andin vivo in rats.Europ. J. Pharmacol. 9: 99–105 (1970). · DOI
- M. Rowland. Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation andin vivo.Europ. J. Pharmacol. 17:352–357 (1972). · DOI
- K. B. Bischoff and R. L. Dedrick. Generalized solution to linear, two-compartment, open model for drug distribution.J. Theoret. Biol. 29: 63–83 (1970). · DOI
- K. B. Bischoff and R. L. Dedrick. Thiopental pharmacokinetics.J. Pharm. Sci. 57: 1346–1351 (1968). · DOI
- K. B. Bischoff, R. L. Dedrick, and D. S. Zaharko. Preliminary model for methotrexate pharmacokinetics.J. Pharm. Sci. 59: 149–154 (1970). · DOI
- H. W. Smith, N. Finkelstein, L. Aliminosa, B. Crawford, and M. Graber. The renal clearances of substituted hippuric acid derivatives and other aromatic acids by dog and man.J. Clin. Invest. 24: 388–404 (1945). · DOI
- R. L. Dedrick, D. D. Forrester, and D. H. W. Ho.In vitro-in vivo correlations of drug metabolism: Deamination of 1-β-d-arabinofuranosylcytosine.Biochem. Pharmacol. 21: 1–16 (1972). · DOI
- R. Nagashima and G. Levy. Effect of perfusion rate and distribution factors on drug elimination kinetics in a perfused organ system.J. Pharm. Sci. 57: 1991–1993 (1968). · DOI
- M. Gibaldi and S. Feldman. Pharmacokinetic basis for the influence of route of administration on the area under the plasma concentration-time curve.J. Pharm. Sci. 58: 1477–1480 (1969). · DOI
Cited by
Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01059688 · Cited by 797
Self-citationPrediction of in vivo drug metabolism in the human liver from in vitro metabolism data
Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., & Sugiyama, Y. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00184-2 · Cited by 479
Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01059689 · Cited by 217
Self-citationOrgan Clearance Concepts: New Perspectives on Old Principles
Sirianni, G. L., & Pang, K. S. (1997) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1023/a:1025792925854 · Cited by 89
Choi, G.-W., Lee, Y.-B., & Cho, H.-Y. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11040168 · Cited by 79
“[34]: CLorg = Q·kel·KP·VE Q + kel·KP·VE (10)”
Method
Metadata
- Authors
- Rowland, M., Benet, L. Z., & Graham, G. G.
- Venue
- Journal of Pharmacokinetics and Biopharmaceutics
- Published
- 1973-04
- Volume
- 1
- Issue
- 2
- Pages
- 123-136
- ISSN
- 0090-466X
- Cited by
- 649
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Clearance concepts in pharmacokinetics. https://app.cochat.ai/papers/10.1007/bf01059626
- The paper
- Rowland, M., Benet, L. Z., & Graham, G. G. (1973). Clearance concepts in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics. https://doi.org/10.1007/bf01059626
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
