Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation
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Using lidocaine with an ER of 0.99 or higher in mice liver perfusion, its metabolite profile is well described by the well-stirred model.
“using lidocaine with an ER of 0.99 or higher, a liver perfusion experiment was conducted in mice. Its metabolite profile is well described by the well-stirred model.”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [44]
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- Authors
- Pang, K. S., & Rowland, M.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Pang, K. Sandy
- Venue
- Journal of Pharmacokinetics and Biopharmaceutics
- Published
- 1977-12
- Volume
- 5
- Issue
- 6
- Pages
- 681-699
- ISSN
- 0090-466X (ISSN-L)
- OpenAlex
- W2052018634
- Cited by
- 77
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Pharmacokinetics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- hepatic clearance, well-stirred model, parallel tube model, lidocaine, liver perfusion, hepatic blood flow, extraction ratio, hepatic metabolism, rat liver
- MeSH terms
- Animals, Lidocaine, Liver, Liver Circulation, Models, Biological, Perfusion, Rats, In Vitro Techniques
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