Cited by 77Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms

Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation

Pang, K. Sandy, Rowland, Malcolm·1977·Journal of Pharmacokinetics and Biopharmaceutics

Integrity signals

Registry

Crossref · 10.1007/bf01059690

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. H. G. Weder, J. Schildknecht, and A. Kesselring. A new equilibrium dialysing system.Am. Lab. 10:15–21 (1971).

Cited by

Sorted by citations

Authors
Pang, K. S., & Rowland, M.
Affiliations
University of California, San Francisco (US)
Venue
Journal of Pharmacokinetics and Biopharmaceutics
Published
1977-12
Volume
5
Issue
6
Pages
681-699
ISSN
0090-466X (ISSN-L)
OpenAlex
W2052018634
Cited by
77
References
16
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2012: 1
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pharmacokinetics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
hepatic clearance, well-stirred model, parallel tube model, lidocaine, liver perfusion, hepatic blood flow, extraction ratio, hepatic metabolism, rat liver
MeSH terms
Animals, Lidocaine, Liver, Liver Circulation, Models, Biological, Perfusion, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review