Hypocholesterolemic effect of blue-green alga, ishikurage (Nostoc commune) in rats fed atherogenic diet
Abstract
Blue-green alga, Nostoc commune is rich in dietary fiber. To examine the hypocholesterolemic effect, the alga or the dietary fibers were given to the rats fed cholesterol diet. Serum cholesterol elevation was significantly depressed in those rats. Cholesterol increased in the liver of rats given the alga and the fiber. The content of fecal cholesterol and bile acid unchanged. Of the dietary fibers, oxalate-oxalic acid soluble substance (OOSS) found abundant in the alga was most effective in lowering cholesterol in the serum. It seems to depress the elevation of LDL-cholesterol. The mechanism of hypocholesterolemic effect by OOSS remains to be unclear. This study indicated that Nostoc commune is expected to be a new dietary fiber source of possible importance in human nutrition.
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Blue-green algae are recognized for protective effects against viral and bacterial infections, cancer, allergy, diabetes, inflammation, and hyperlipidemia.
“They are recognized for their protective effects against viral and bacterial infections, cancer, allergy, diabetes, inflammation and hyperlipidemia [26–29].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [29]
Cites
Shaw, R., & Elliott, W. H. (1978) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41282-9 · Cited by 54 · see citing works
Hori, K., Ueno-Mohri, T., Okita, T., & Ishibashi, G. (1990) · Plant Foods for Human Nutrition · doi:10.1007/bf01104146 · Cited by 21 · see citing works
Self-citationEffect of rice bran hemicellulose on the cholesterol metabolism in rats.
Aoe, S., Fukio, O. H. T. A., & AYANO, Y. (1989) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.42.55 · Cited by 21 · see citing works
Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects
Cara, L., Borel, P., Armand, M., Senft, M., Lafont, H., Portugal, H., Pauli, A.-M., Boulze, D., Lacombe, C., & Lairon, D. (1991) · Plant Foods for Human Nutrition · doi:10.1007/bf02194082 · Cited by 17 · see citing works
AYANO, Y., Fukio, O. H. T. A., Watanabe, Y., & Kozo, M. I. T. A. (1980) · Eiyo to shokuryo/Eiyo To Shokuryo · doi:10.4327/jsnfs1949.33.283 · Cited by 10 · see citing works
Hori, K., Ueno-Mohri, T., & Okita, T. (1992) · Plant Foods for Human Nutrition · doi:10.1007/bf02196070 · Cited by 8 · see citing works
Self-citationKlopfenstein, C. F. (1990) · Cereal Chemistry · Cited by 8 · see citing works
Hypocholesterolemic effect of guargum in overweight adults
Kawatra, A., Kapoor, A. C., & Seghal, S. (1991) · Plant Foods for Human Nutrition · doi:10.1007/bf02196392 · Cited by 7 · see citing works
Metabolic effects of insoluble oat fiber of lean men with type II diabetes
Anderson, J., Hamilton, C., Horn, J.-L., Spencer, D. B., Dillon, D. W., & Zeigler, J. A. (1991) · Cereal Chemistry · Cited by 7 · see citing works
Okita, T., & Sugano, M. (1989) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.53.659 · Cited by 6 · see citing works
Self-citationEffect of Egonori or Asakusanori Feeding on the Liver and Serum Lipid Levels of Rats
Cho, S. (1983) · Journal of home economics · doi:10.11428/jhej1951.34.826 · Cited by 1 · see citing works
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Cited by
Sorted by citations
Microalgae in Human and Animal Nutrition
Becker, W. (2003) · Handbook of Microalgal Culture · doi:10.1002/9780470995280.ch18 · Cited by 613 · see citing works
Microalgae of interest as food source: biochemical composition and digestibility.
Niccolai, A., Chini Zittelli, G., Rodolfi, L., Biondi, N., & Tredici, M. R. (2019) · Algal Research · doi:10.1016/j.algal.2019.101617 · Cited by 403 · see citing works
Dodds, W. K., Gudder, D. A., & Mollenhauer, D. (1995) · Journal of Phycology · doi:10.1111/j.0022-3646.1995.00002.x · Cited by 345 · see citing works
Cyanobacterial biofertilizers in rice agriculture
Vaishampayan, A., Sinha, R. P., Häder, D., Dey, T., Gupta, A., Bhan, U., & Rao, A. L. (2001) · The Botanical Review · doi:10.1007/bf02857893 · Cited by 244 · see citing works
Pathak, J., Rajneesh, Maurya, P. K., Singh, S. P., Häder, D., & Sinha, R. P. (2018) · Frontiers in Environmental Science · doi:10.3389/fenvs.2018.00007 · Cited by 238 · see citing works
Barth, H. G., Jackson, C., & Boyes, B. E. (1994) · Analytical Chemistry · doi:10.1021/ac00084a022 · Cited by 223 · see citing works
Sustainability and cyanobacteria (blue-green algae): facts and challenges
Sharma, N. K., Tiwari, S. P., Tripathi, K., & Rai, A. K. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9626-3 · Cited by 178 · see citing works
Ku, C. S., Yang, Y. J., Park, Y., & Lee, J. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2468 · Cited by 113 · see citing works
Rasmussen, H. E., Blobaum, K. R., Park, Y., Ehlers, S. J., Lu, F., & Lee, J. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.476 · Cited by 110 · see citing works
Ku, C. S., Pham, T. X., Park, Y., Kim, B., Shin, M. S., Kang, I., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.018 · Cited by 109 · see citing works
Blue-Green Algae as an Immuno-Enhancer and Biomodulator
Jensen, G. S., Ginsberg, D. I., & Drapeau, C. (2001) · Cited by 104 · see citing works
Park, Y.-K., Rasmussen, H. E., Ehlers, S. J., Blobaum, K. R., Lu, F., Schlegal, V. L., Carr, T. P., & Lee, J.-Y. (2008) · Nutrition Research · doi:10.1016/j.nutres.2007.11.008 · Cited by 103 · see citing works
Vichi, S., Lavorini, P., Funari, E., Scardala, S., & Testai, E. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.09.029 · Cited by 101 · see citing works
Metabolites produced by nitrogen-fixingNostoc species
Dembitsky, V. M., & Řezanka, T. (2005) · Folia Microbiologica · doi:10.1007/bf02931419 · Cited by 94 · see citing works
Microviridins, elastase inhibitors from the cyanobacterium Nostoc minutum (NIES-26)
Murakami, M., Sun, Q., Ishida, K., Matsuda, H., Okino, T., & Yamaguchi, K. (1997) · Phytochemistry · doi:10.1016/s0031-9422(97)00131-3 · Cited by 72 · see citing works
Yang, Y., Park, Y., Cassada, D. A., Snow, D. D., Rogers, D. G., & Lee, J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.052 · Cited by 65 · see citing works
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Veluchamy, C., & Palaniswamy, R. (2020) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i3.36130 · Cited by 58 · see citing works
Risk Assessment of Microcystin in Dietary Aphanizomenon flos-aquae
Schaeffer, D. J., Malpas, P. B., & Barton, L. L. (1999) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1999.1816 · Cited by 51 · see citing works
Healthy efficacy of Nostoc commune Vaucher
Li, Z., & Guo, M. (2017) · Oncotarget · doi:10.18632/oncotarget.23620 · Cited by 50 · see citing works
Safety evaluation of Nostoc flagelliforme (nostocales, cyanophyceae) as a potential food
Takenaka, H., Yamaguchi, Y., Sakaki, S., Watarai, K., Тanaka, N., Hori, M., Seki, H., Tsuchida, M., Yamada, A., Nishimori, T., et al. (1998) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(98)00089-1 · Cited by 48 · see citing works
Itoh, T., Tsuzuki, R., Tanaka, T., Ninomiya, M., Yamaguchi, Y., Takenaka, H., Andô, M., Tsukamasa, Y., & Koketsu, M. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.016 · Cited by 44 · see citing works
Manolidi, K., Triantis, T. M., Kaloudis, T., & Hiskia, A. E. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.10.084 · Cited by 43 · see citing works
Kuriakose, G. C., & Kurup, G. M. (2011) · Food & Function · doi:10.1039/c0fo00163e · Cited by 42 · see citing works
Itoh, T., Koketsu, M., Yokota, N., Touho, S., Andô, M., & Tsukamasa, Y. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.019 · Cited by 37 · see citing works
Hypocholesterolemic effect of Nostoc commune var. sphaeroides Kützing, an edible blue-green alga
Rasmussen, H. E., Blobaum, K. R., Jesch, E. D., Ku, C. S., Park, Y.-K., Lu, F., Carr, T. P., & Lee, J. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0025-y · Cited by 37 · see citing works
Rasmussen, H. E., Martínez, I., Lee, J. Y., & Walter, J. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04288.x · Cited by 32 · see citing works
Liao, H., Wu, T.-J., Tai, J.-L., Chi, M., & Lin, L. (2015) · Medical Sciences · doi:10.3390/medsci3040112 · Cited by 29 · see citing works
Sánchez-Parra, E., Boutarfa, S., & Aboal, M. (2020) · Toxins · doi:10.3390/toxins12090552 · Cited by 30 · see citing works
Favorable Effects of Blue-Green Algae Aphanizomenon flos-aquae on Rat Plasma Lipids
Kushak, R. I., Drapeau, C., Cott, E. M. V., & Winter, H. S. (2000) · Cited by 27 · see citing works
Watanabe, F., Tanioka, Y., Miyamoto, E., Fujita, T., Takenaka, H., & Nakano, Y. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.183 · Cited by 25 · see citing works
Itoh, T., Tsuchida, A., Muramatsu, Y., Ninomiya, M., Andô, M., Tsukamasa, Y., & Koketsu, M. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.006 · Cited by 27 · see citing works
Ku, C. S., Kim, B., Pham, T. X., Yang, Y. J., Wegner, C., Park, Y., Balunas, M. J., & Lee, J. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2015.0025 · Cited by 23 · see citing works
Ku, C. S., Kim, B., Pham, T. X., Yang, Y. J., Weller, C. L., Carr, T. P., Park, Y., & Lee, J. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0121 · Cited by 23 · see citing works
Vaishampayan, A., Sinha, R. P., & Häder, D. (1998) · Botanica Acta · doi:10.1111/j.1438-8677.1998.tb00693.x · Cited by 23 · see citing works
Zhu, S., Xu, J., Adhikari, B., Lv, W., & Chen, H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2063251 · Cited by 31 · see citing works
Kruså, M., Torre, M., & Marina, M. L. (2000) · Analytical Chemistry · doi:10.1021/ac990776m · Cited by 21 · see citing works
Jensen, G. S., Ginsberg, D. I., Huerta, P., Citton, M., & Drapeau, C. (2000) · Cited by 17 · see citing works
Briones‐Nagata, M. P., Martinez-Goss, M. R., & Hori, K. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9240-1 · Cited by 16 · see citing works
Self-citationCommercial‐scale culturing of cyanobacteria: an industrial experience
Takenaka, H., & Yamaguchi, Y. (2013) · Wiley eBooks · doi:10.1002/9781118402238.ch18 · Cited by 16 · see citing works
Wang, Y., Wang, C., Dang, J., Xue, H.-Y., Wang, X., Jin, Y., Yang, M., Leng, F., & Zhang, B. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abe978 · Cited by 14 · see citing works
Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice
Lee, J. (2014) · Journal of Nutritional Health & Food Science · doi:10.15226/jnhfs.2014.00108 · Cited by 12 · see citing works
Evaluation of a Cyanobacterium, Nostoc sp. HK-01, as Food Material for Space Agriculture on Mars
Kimura, Y., Kimura, S., Sato, S., Katoh, H., Abe, T., Arai, M., & Tomita‐Yokotani, K. (2015) · Biological Sciences in Space · doi:10.2187/bss.29.24 · Cited by 9 · see citing works
Briones, M. P. P., Hori, K., Martinez-Goss, M. R., Ishibashi, G., & Okita, T. (1997) · Plant Foods for Human Nutrition · doi:10.1007/bf02436075 · Cited by 6 · see citing works
Self-citationBiology and Biotechnology of EdibleNostoc
Han, D., Deng, Z., Lu, F., & Hu, Z. (2013) · Wiley eBooks · doi:10.1002/9781118567166.ch23 · Cited by 4 · see citing works
Effect of plant fruits – Indian gall nut, bedda nut and gooseberry – on hypercholesterolemic rats
Nalini, D., & Kapoor, R. (1999) · Plant Foods for Human Nutrition · doi:10.1023/a:1008001829094 · Cited by 3 · see citing works
Itoh, T., Muramatsu, Y., Masu, M., Tsuge, A., Taniguchi, M., Ninomiya, M., Andô, M., Tsukamasa, Y., & Koketsu, M. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.956255 · Cited by 2 · see citing works
Nostoc genties melsvabakterių įvairovė ir jos apsauga Lietuvoje
Špakaitė, I., & Kostkevičienė, J. (2011) · Mokslas - Lietuvos ateitis · doi:10.3846/mla.2009.4.04
- Authors
- Hori, K., Ishibashi, G., & Okita, T.
- Affiliations
- Fukuoka University (JP)
- Kyushu Women's University (JP)
- Venue
- Plant Foods for Human Nutrition
- Published
- 1994-01
- Volume
- 45
- Issue
- 1
- Pages
- 63-70
- ISSN
- 0033-5134 (ISSN-L)
- 0921-9668
- 1573-9104
- OpenAlex
- W2091363304
- Cited by
- 47
- References
- 11
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Plant Foods for Human Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- Nostoc commune, cyanobacteria, cholesterol-lowering effect, dietary fiber, serum cholesterol, LDL cholesterol, atherogenic diet, cholesterol, liver cholesterol, bile acids, fecal cholesterol, functional foods
- MeSH terms
- Cyanobacteria, Animals, Cholesterol, Diet, Atherogenic, Dietary Fiber, Lipids, Liver, Male, Triglycerides, Rats, Wistar, Rats
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