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Stretch activated ion channels in ventricular myocytes
Abstract
Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (>40 seconds) stretch applications. The channels have a conductance averaging 120 pS in isotonic KCl, have a mean reversal potential 31 mV depolarized from resting membrane potential, and do not require external Ca++ for activation. The channels appear to be relatively non-selective for cations. Since they are gated by physiological levels of tension, stretch-activated channels may represent, a cellular control system wherein beat-to-beat tension and/or osmotic balance modulate a portion of membrane conductance.
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Cited by
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Franz, M. R., Cima, R., Wang, D., Profitt, D., & Kurz, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.968 · Cited by 411
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Luo, M., & Anderson, M. E. (2013) · Circulation Research · doi:10.1161/circresaha.113.301651 · Cited by 357
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Metadata
- Authors
- Craelius, W., Chen, V., & El-Sherif, N.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 1988-10-01
- Volume
- 8
- Issue
- 5
- Pages
- 407-414
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W2020452164
- Cited by
- 190
- References
- 0
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Craelius, W., Chen, V., & El-Sherif, N. (1988). Stretch activated ion channels in ventricular myocytes. Bioscience Reports. https://doi.org/10.1007/bf01121637
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