Enzyme activities in quadriceps femoris muscle of obese diabetic male patients
Open accessAbstract
In biopsy samples of the lateral part of the quadriceps femoris muscle of 6 obese diabetic male patients and of 11 obese males with a normal glucose tolerance, the activities of 7 enzymes of energy metabolism were estimated: hexokinase, cytoplasmic glycerol-3-phosphate: NAD dehydrogenase, triosephosphate dehydrogenase, lactate dehydrogenase, citrate synthase, malate dehydrogenase and 3-hydroxyacyl-CoA dehydrogenase. The obese diabetic male patients exhibited decreased activities of enzymes of carbohydrate breakdown and cytoplasmic NAD regeneration. Enzymes connected functionally with aerobic metabolism were less affected. The unchanged activity of 3-hydroxyacyl-CoA dehydrogenase points to an increased role of fatty acid catabolism in the muscle.
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Mitochondrial mass is 14-38% lower in muscle in obesity and type 2 diabetes.
“Mitochondrial mass is consistently 14–38% lower in muscle in obesity and type 2 diabetes (2–5).”
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- Authors
- Vondra, K., Rath, R., Bass, A., Slabochov�, Z., Teisinger, J., & V�tek, V.
- Affiliations
- Czech Academy of Sciences (CZ)
- Venue
- Diabetologia
- Published
- 1977-09
- Volume
- 13
- Issue
- 5
- Pages
- 527-529
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2007686150
- Cited by
- 48
- References
- 16
- Citations by year
- 2025: 2 · 2024: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2017: 3 · 2015: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- quadriceps, obesity, diabetes mellitus, muscle enzyme activity, energy metabolism, hexokinase, glycerol-3-phosphate dehydrogenase, triosephosphate dehydrogenase, lactate dehydrogenase, citrate synthase, malate dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase, fatty acid degradation, carbohydrate metabolism, NAD+ regeneration, aerobic metabolism
- MeSH terms
- Citrate (si)-Synthase, Diabetes Mellitus, Glyceraldehyde-3-Phosphate Dehydrogenases, Glycerolphosphate Dehydrogenase, Hexokinase, Humans, L-Lactate Dehydrogenase, Malate Dehydrogenase, Male, Muscles, Obesity, 3-Hydroxyacyl CoA Dehydrogenases
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