The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

Gene Ontology: tool for the unification of biology

Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works

Gentleman R: R: A language for data analysis and graphics

Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Effects of Intensive Glucose Lowering in Type 2 Diabetes

(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888 · see citing works

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802987 · Cited by 7,397 · see citing works

The Pathobiology of Diabetic Complications

Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Nonparametrics: Statistical Methods Based on Ranks

Mergenthaler, M. J., & Lehmann, E. L. (1979) · Technometrics · doi:10.2307/1268531 · Cited by 3,353 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Butyrate improves insulin sensitivity and increases energy expenditure in mice

Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works

Obesity and Diabetes in the Developing World — A Growing Challenge

Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924 · see citing works

Polycystic Ovary Syndrome

Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,884 · see citing works

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707 · see citing works

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

(2006) · The Lancet · doi:10.1016/s0140-6736(06)69420-8 · Cited by 1,706 · see citing works

PPARs and the complex journey to obesity

Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works

The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study

Li, G., Zhang, P., Wang, J., Gregg, E. W., Yang, W., Gong, Q., Li, H., Li, H., Jiang, Y., An, Y., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60766-7 · Cited by 1,600 · see citing works

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Decline in skeletal muscle mitochondrial function with aging in humans

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works

Human aging, muscle mass, and fiber type composition.

Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308 · see citing works

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267 · see citing works

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide

Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243 · see citing works

Pathophysiology of insulin resistance in human disease

Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,235 · see citing works

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works

Physical activity and incidence of non-insulin-dependent diabetes mellitus in women

Manson, J. E., Stampfer, M. J., Colditz, G. A., Willett, W. C., Rosner, B., Hennekens, C. H., Speizer, F. E., Rimm, E. B., & Krolewski, A. S. (1991) · The Lancet · doi:10.1016/0140-6736(91)90664-b · Cited by 1,164 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

The EMBL Nucleotide Sequence Database

Baker, W. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.19 · Cited by 1,107 · see citing works

Biliverdin reductase: A major physiologic cytoprotectant

Barañano, D. E., Rao, M., Ferris, C. D., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252626999 · Cited by 1,091 · see citing works

Regulation of Muscle Fiber Type and Running Endurance by PPARδ

Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

Oliver, W. R., Shenk, J. L., Snaith, M. R., RUSSELL, C. S., Plunket, K. D., Bodkin, N. L., Lewis, M. C., Winegar, D. A., Sznaidman, M. L., Lambert, M. H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091021198 · Cited by 1,048 · see citing works

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

Salmeen, A., Andersen, J. N., Myers, M. P., Meng, T.-C., Hinks, J. A., Tonks, N. K., & Barford, D. (2003) · Nature · doi:10.1038/nature01680 · Cited by 951 · see citing works

The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial

Orchard, T. J., Temprosa, M., Goldberg, R., Haffner, S., Ratner, R., Marcovina, S., Fowler, S., & for the Diabetes Prevention Program Research Group (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-8-200504190-00009 · Cited by 948 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans

Fontana, L., Meyer, T. E., Klein, S., & Holloszy, J. O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308291101 · Cited by 902 · see citing works

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.581 · Cited by 897 · see citing works

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

Smith, S. J., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, J., Eckel, R. H., & Farese, R. V. (2000) · Nature Genetics · doi:10.1038/75651 · Cited by 895 · see citing works

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

Morino, K., Petersen, K. F., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/db06-s002 · Cited by 853 · see citing works

Role of Myokines in Exercise and Metabolism

Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841 · see citing works

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents

Morino, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25151 · Cited by 811 · see citing works

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works

Is NF-kappaB the sensor of oxidative stress?

Li, N., & Karin, M. (1999) · PubMed · Cited by 786 · see citing works

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works

Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man

Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782 · see citing works

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802187200 · Cited by 778 · see citing works

A Prospective Study of Exercise and Incidence of Diabetes Among US Male Physicians

Manson, J. E. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03490010065031 · Cited by 778 · see citing works

SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

Sun, C., Zhang, F., Ge, X., Yan, T., Chen, X., Shi, X., & Zhai, Q. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.014 · Cited by 766 · see citing works

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works

Defective Uptake and Utilization of Long Chain Fatty Acids in Muscle and Adipose Tissues of CD36 Knockout Mice

Coburn, C. T., Knapp, F. F., Febbraio, M., Beets, A. L., Silverstein, R. L., & Abumrad, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003826200 · Cited by 726 · see citing works

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719 · see citing works

Effect of Vanadate on Elevated Blood Glucose and Depressed Cardiac Performance of Diabetic Rats

Heyliger, C. E., Tahiliani, A. G., & McNeill, J. H. (1985) · Science · doi:10.1126/science.3156405 · Cited by 717 · see citing works

Cross-Talk Between Iron Metabolism and Diabetes

Fernández-Real, J. M., López-Bermejo, A., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2348 · Cited by 704 · see citing works

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 670 · see citing works

The mitochondrial uncoupling-protein homologues

Krauss, S., Zhang, C., & Lowell, B. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1592 · Cited by 663 · see citing works

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

Michael, L. F., Wu, Z., Cheatham, R. B., Puigserver, P., Adelmant, G., Lehman, J. J., Kelly, D. P., & Spiegelman, B. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061035098 · Cited by 663 · see citing works

Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice

Zang, M., Xu, S., Maitland, K. A., Zuccollo, A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2006) · Diabetes · doi:10.2337/db05-1188 · Cited by 663 · see citing works

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

Tripathy, D., Mohanty, P., Dhindsa, S., Syed, T., Ghanim, H., Aljada, A., & Dandona, P. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2882 · Cited by 658 · see citing works

Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.

Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657 · see citing works

Lipid oxidation is reduced in obese human skeletal muscle

Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works

Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631 · see citing works

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R., Hulver, M. W., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1926 · Cited by 629 · cited 1× · see citing works

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

Ratziu, V., Giral, P., Jacqueminet, S., Charlotte, F., Hartemann–Heurtier, A., Serfaty, L., Podevin, P., Lacorte, J., Bernhardt, C., Bruckert, E., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.078 · Cited by 625 · see citing works

AIF deficiency compromises oxidative phosphorylation

Vahsen, N., Candé, C., Brière, J.-J., Bénit, P., Joza, N. A., Larochette, N., Mastroberardino, P. G., Péquignot, M. O., Casares, N., Lazar, V., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600461 · Cited by 622 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals.

Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604 · see citing works

Endurance Exercise as a Countermeasure for Aging

Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582 · see citing works

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works

The Biology of Mitochondrial Uncoupling Proteins

Rousset, S., Alves‐Guerra, M., Mozo, J., Miroux, B., Cassard, A., Bouillaud, F., & Ricquier, D. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s130 · Cited by 556 · see citing works

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works

Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

LEE, H.-C., YIN, P.-H., LU, C.-Y., CHI, C.-W., & WEI, Y.-H. (2000) · Biochemical Journal · doi:10.1042/bj3480425 · Cited by 551 · see citing works

Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · cited 3× · see citing works

Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes

Scheuermann-Freestone, M., Madsen, P. L., Manners, D., Blamire, A. M., Buckingham, R. E., Styles, P., Radda, G. K., Neubauer, S., & Clarke, K. (2003) · Circulation · doi:10.1161/01.cir.0000072789.89096.10 · Cited by 525 · see citing works

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsøe, R., & Dela, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0594-3 · Cited by 519 · see citing works

PPAR-γ regulates osteoclastogenesis in mice

Wan, Y., Chong, L.-W., & Evans, R. M. (2007) · Nature Medicine · doi:10.1038/nm1672 · Cited by 513 · see citing works

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., & Goldstein, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1844-1854.2004 · Cited by 513 · see citing works

Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low‐intensity activity

Bey, L., & Hamilton, M. T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045591 · Cited by 509 · see citing works

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497 · see citing works

PPARδ regulates glucose metabolism and insulin sensitivity

Lee, C., Olson, P., Hevener, A. L., Mehl, I. R., Chong, L.-W., Olefsky, J. M., Gonzalez, F. J., Ham, J., Kang, H., Peters, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511253103 · Cited by 495 · see citing works

Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle

Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works

Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance

Kiens, B. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2004 · Cited by 478 · see citing works

Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

Stump, C. S., Short, K. R., Bigelow, M. L., Schimke, J. M., & Nair, K. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332551100 · Cited by 477 · see citing works

Rat PPARs: Quantitative Analysis in Adult Rat Tissues and Regulation in Fasting and Refeeding

Escher, P., Braissant, O., Modak, S. B., Michalik, L., Wahli, W., & Desvergne, B. (2001) · Endocrinology · doi:10.1210/endo.142.10.8458 · Cited by 473 · see citing works

The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men

Wei, M., Gibbons, L. W., Mitchell, T. L., Kampert, J. B., Lee, C. D., & Blair, S. N. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-2-199901190-00002 · Cited by 472 · see citing works

Nuclear Receptor Signaling and Cardiac Energetics

Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467 · see citing works

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works

Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes · doi:10.2337/db06-0783 · Cited by 453 · see citing works

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM

Simoneau, J.-A., & Kelley, D. E. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.166 · Cited by 441 · see citing works

FGF21 is an Akt‐regulated myokine

Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

Boss, O., Hagen, T., & Lowell, B. B. (2000) · Diabetes · doi:10.2337/diabetes.49.2.143 · Cited by 414 · see citing works

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men

Petersen, K. F., Dufour, S., Feng, J., Befroy, D., Dziura, J., Man, C. D., Cobelli, C., & Shulman, G. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608537103 · Cited by 403 · see citing works

Effects of exercise on mitochondrial content and function in aging human skeletal muscle

Menshikova, E. V., Ritov, V. B., Fairfull, L., Ferrell, R. E., Kelley, D. E., & Goodpaster, B. H. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.6.534 · Cited by 398 · see citing works

Characterization of the insulin resistance of aging.

Rowe, J. W., Minaker, K. L., Pallotta, J. A., & Flier, J. S. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110914 · Cited by 396 · see citing works

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

Izumiya, Y., Hopkins, T., Morris, C., Sato, K., Zeng, L., Viereck, J., Hamilton, J. A., Ouchi, N., LeBrasseur, N. K., & Walsh, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.003 · Cited by 395 · cited 8× · see citing works

Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans

Krebs, M., Krssak, M., Bernroider, E., Anderwald, C., Brehm, A., Meyerspeer, M., Nowotny, P., Roth, E., Waldhäusl, W., & Roden, M. (2002) · Diabetes · doi:10.2337/diabetes.51.3.599 · Cited by 392 · see citing works

A glucose transport protein expressed predominately in insulin-responsive tissues.

Charron, M. J., Brosius, F. C., Alper, S. L., & Lodish, H. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2535 · Cited by 390 · see citing works

Glucose intolerance and aging

DeFronzo, R. A. (1981) · Diabetes Care · doi:10.2337/diacare.4.4.493 · Cited by 389 · see citing works

Effect of Aging on A1C Levels in Individuals Without Diabetes

Pani, L. N., Korenda, L., Meigs, J. B., Driver, C., Chamany, S., Fox, C. S., Sullivan, L., D’Agostino, R. B., & Nathan, D. M. (2008) · Diabetes Care · doi:10.2337/dc08-0577 · Cited by 378 · see citing works

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

Keller, M. P., Choi, Y., Wang, P., Belt Davis, D., Rabaglia, M. E., Oler, A. T., Stapleton, D. S., Argmann, C., Schueler, K. L., Edwards, S., et al. (2008) · Genome Research · doi:10.1101/gr.074914.107 · Cited by 377 · see citing works

Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects

Daussin, F. N., Zoll, J., Dufour, S. P., Ponsot, E., Lonsdorfer-Wolf, E., Doutreleau, S., Mettauer, B., Piquard, F., Geny, B., & Richard, R. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00875.2007 · Cited by 375 · see citing works

Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells.

Scarpulla, R. (2002) · Gene · doi:10.1016/s0378-1119(01)00809-5 · Cited by 371 · see citing works

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

Schuler, M. J., Ali, F., Chambon, C., Duteil, D., Bornert, J., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., & METZGER, D. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.003 · Cited by 368 · see citing works

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

Stenbit, A. E., Tsao, T., Li, J., Burcelin, R., Geenen, D. L., Factor, S. M., Houseknecht, K. L., Katz, E. B., & Charron, M. J. (1997) · Nature Medicine · doi:10.1038/nm1097-1096 · Cited by 367 · see citing works

Time course of loss of adaptations after stopping prolonged intense endurance training

Coyle, E. F., Martin, W. H., Sinacore, D. R., Joyner, M. J., Hagberg, J. M., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.6.1857 · Cited by 364 · see citing works

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance

Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes · doi:10.2337/db08-1078 · Cited by 363 · see citing works

Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.

Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781930 · Cited by 362 · see citing works

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J.-P., Hesselink, M. K. C., et al. (2008) · Diabetes · doi:10.2337/db08-0391 · Cited by 359 · see citing works

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356 · see citing works

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

Coll, T., Eyre, E., Rodríguez-Calvo, R., Palomer, X., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708700200 · Cited by 347 · see citing works

Time Course of Changes in Human Skeletal Muscle Succinate Dehydrogenase and Cytochrome Oxidase Activities and Maximal Oxygen Uptake with Physical Activity and Inactivity

Henriksson, J., & Reitman, J. S. (1977) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1977.tb10356.x · Cited by 345 · see citing works

Muscle Fiber Composition and Capillary Density in Women and Men With NIDDM

Mårin, P., Andersson, B., Krotkiewski, M., & Björntorp, P. A. (1994) · Diabetes Care · doi:10.2337/diacare.17.5.382 · Cited by 342 · see citing works

Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1

Chen, H. C., Smith, S. J., Ladha, Z., Jensen, D. R., Ferreira, L. D., Pulawa, L. K., McGuire, J. G., Pitas, R. E., Eckel, R. H., & Farese, R. V. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14672 · Cited by 329 · see citing works

Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.

Cohen, N., Halberstam, M., Shlimovich, P., Chang, C., Shamoon, H., & Rossetti, L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117951 · Cited by 327 · see citing works

Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways

Kubota, N., Terauchi, Y., Kubota, T., Kumagai, H., Itoh, S., Satoh, H., Yano, W., Ogata, H., Tokuyama, K., Takamoto, I., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m505649200 · Cited by 327 · see citing works

Redox Paradox

Goldstein, B. J., Mahadev, K., & Wu, X. (2005) · Diabetes · doi:10.2337/diabetes.54.2.311 · Cited by 326 · see citing works

Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men

Risérus, U., Sprecher, D. L., Johnson, T., Olson, E., Hirschberg, S., Liu, A., Fang, Z., Hegde, P. S., Richards, D. B., Sarov-Blat, L., et al. (2007) · Diabetes · doi:10.2337/db07-1318 · Cited by 326 · see citing works

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

Lee, J. S., Pinnamaneni, S. K., Eo, S. J., Cho, I. H., Pyo, J. H., Kim, C. K., Sinclair, A. J., Febbraio, M. A., & Watt, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01438.2005 · Cited by 325 · see citing works

Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.

Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., & Kelley, D. E. (2007) · Diabetes · doi:10.2337/db07-0141 · Cited by 321 · see citing works

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.

Sakamoto, J., Kimura, H., Moriyama, S., Odaka, H., Momose, Y., Sugiyama, Y., & Sawada, H. (2000) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.2000.3868 · Cited by 313 · see citing works

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

Petersen, K. F., Dufour, S., & Shulman, G. I. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020233 · Cited by 308 · see citing works

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

Schrauwen-Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Jeneson, J. A. L., Backes, W. H., van Echteld, C. J. A., van Engelshoven, J. M. A., Mensink, M., & Schrauwen, P. (2007) · Diabetologia · doi:10.1007/s00125-006-0475-1 · Cited by 304 · see citing works

FATP1 Is an Insulin-Sensitive Fatty Acid Transporter Involved in Diet-Induced Obesity

Wu, Q., Ortegon, A. M., Tsang, B., Doege, H., Feingold, K. R., & Stahl, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3455-3467.2006 · Cited by 296 · see citing works

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling

Corbould, A., Kim, Y.-B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2004 · Cited by 283 · see citing works

Mitochondria and Diabetes: Genetic, Biochemical, and Clinical Implications of the Cellular Energy Circuit

Gerbitz, K.-D., Gempel, K. E., & Brdiczka, D. G. (1996) · Diabetes · doi:10.2337/diab.45.2.113 · Cited by 281 · see citing works

Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810339105 · Cited by 279 · see citing works

Significance of skeletal muscle oxidative enzyme enhancement with endurance training.

Gollnick, P. D., & Saltin, B. (1982) · Clinical Physiology · doi:10.1111/j.1475-097x.1982.tb00001.x · Cited by 277 · see citing works

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

Hajri, T., Han, X. X., Bonen, A., & Abumrad, N. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14596 · Cited by 277 · see citing works

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270 · see citing works

Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis

Meyer, C., Dostou, J. M., Welle, S. L., & Gerich, J. E. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00032.2001 · Cited by 269 · see citing works

Impact of short‐term high‐fat feeding on glucose and insulin metabolism in young healthy men

Brøns, C., Jensen, C. B., Storgaard, H., Hiscock, N. J., White, A., Appel, J. S., Jacobsen, S., Nilsson, E., Larsen, C. M., Astrup, A. V., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169078 · Cited by 268 · see citing works

Sarcopenia of Aging and Its Metabolic Impact

Karakelides, H., & Nair, K. S. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)68005-2 · Cited by 264 · see citing works

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

Richardson, D. K., Kashyap, S., Bajaj, M., Cusi, K., Mandarino, S. J., Finlayson, J., DeFronzo, R. A., Jenkinson, C. P., & Mandarino, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408985200 · Cited by 259 · see citing works

Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonella foenum graecum)

Genet, S., Kale, R. K., & Baquer, N. Z. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1016103131408 · Cited by 258 · see citing works

Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment

Sreekumar, R., Halvatsiotis, P., Schimke, J. C., & Nair, K. S. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1913 · Cited by 257 · see citing works

Regulation of Fat Metabolism in Skeletal Muscle

Jeukendrup, A. E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04278.x · Cited by 254 · see citing works

Genetic Factors in Type 2 Diabetes: The End of the Beginning?

O’Rahilly, S., Barroso, I., & Wareham, N. J. (2005) · Science · doi:10.1126/science.1104346 · Cited by 252 · see citing works

Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux

Yoshida, K., Hirokawa, J., Tagami, S., Kawakami, Y., Urata, Y., & Kondo, T. (1995) · Diabetologia · doi:10.1007/bf00400095 · Cited by 248 · see citing works

Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

Dimopoulos, N., Watson, M., Sakamoto, K., & Hundal, H. S. (2006) · Biochemical Journal · doi:10.1042/bj20060244 · Cited by 247 · see citing works

Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle

Garcia-Roves, P., Huss, J. M., Han, D.-H., Hancock, C. R., Iglesias-Gutierrez, E., Chen, M., & Holloszy, J. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704024104 · Cited by 246 · see citing works

Muscle Mitochondrial ATP Synthesis and Glucose Transport/Phosphorylation in Type 2 Diabetes

Szendroedi, J., Schmid, A. I., Chmelik, M., Toth, C., Brehm, A., Krssak, M., Nowotny, P., Wolzt, M., Waldhausl, W., & Roden, M. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040154 · Cited by 243 · see citing works

Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle

Brehm, A., Krssak, M., Schmid, A. I., Nowotny, P., Waldhäusl, W., & Roden, M. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1286 · Cited by 239 · see citing works

One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adipose Tissue

Racette, S. B., Weiss, E. P., Villareal, D. T., Arif, H., Steger-May, K., Schechtman, K. B., Fontana, L., Klein, S., & Holloszy, J. O. (2006) · The Journals of Gerontology: Series A · doi:10.1093/gerona/61.9.943 · Cited by 237 · see citing works

Reduced physical activity and risk of chronic disease: the biology behind the consequences

Booth, F. W., Laye, M. J., Lees, S. J., Rector, R. S., & Thyfault, J. P. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0606-5 · Cited by 236 · see citing works

FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

Arner, P., Pettersson, A., Mitchell, P. J., Dunbar, J. D., Kharitonenkov, A., & Rydén, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.038 · Cited by 234 · see citing works

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

Hajri, T., Han, X. X., Bonen, A., & Abumrad, N. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214596 · Cited by 228 · see citing works

Proteome Analysis Reveals Phosphorylation of ATP Synthase β-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes

Højlund, K., Wrzesinski, K., Larsen, P. M., Fey, S. J., Roepstorff, P., Handberg, A., Dela, F., Vinten, J., McCormack, J. G., Reynet, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212881200 · Cited by 221 · see citing works

Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content

Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218 · see citing works

Regulation of Mitochondrial Biogenesis by Thyroid Hormone

Weitzel, J. M., Iwen, K. A., & Seitz, H. J. (2003) · Experimental Physiology · doi:10.1113/eph8802506 · Cited by 218 · see citing works

Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity

Haram, P. M., Kemi, O. J., Lee, S. J., Bendheim, M. Ø., Al–Share, Q. Y., Waldum, H. L., Gilligan, L. J., Koch, L. G., Britton, S. L., Najjar, S. M., et al. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn332 · Cited by 216 · see citing works

Effect of 6‐Month Calorie Restriction and Exercise on Serum and Liver Lipids and Markers of Liver Function

Larson‐Meyer, D. E., Newcomer, B. R., Heilbronn, L. K., Vólaufová, J., Smith, S. R., Alfonso, A. J., LeFevre, M. L., Rood, J. C., Williamson, D. A., Ravussin, É., et al. (2008) · Obesity · doi:10.1038/oby.2008.201 · Cited by 214 · see citing works

Modest PGC-1α Overexpression in Muscle in Vivo Is Sufficient to Increase Insulin Sensitivity and Palmitate Oxidation in Subsarcolemmal, Not Intermyofibrillar, Mitochondria

Benton, C. R., Nickerson, J. G., Lally, J., Han, X.-X., Holloway, G. P., Glatz, J. F. C., Luiken, J. J. F. P., Graham, T. E., Heikkila, J. J., & Bonen, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704332200 · Cited by 214 · see citing works

Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non—insulin-dependent diabetes mellitus

Boden, G. H., Chen, X., Ruiz, J., van Rossum, G. D. V., & Turco, S. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90013-x · Cited by 212 · see citing works

Adaptation of mitochondrial ATP production in human skeletal muscle to endurance training and detraining.

Wibom, R., Hultman, E., Johansson, M., Matherei, K., Constantin-Teodosiu, D., & Schantz, P. G. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.2004 · Cited by 208 · see citing works

Innate immunity, insulin resistance and type 2 diabetes

Fernández‐Real, J. M., & Pickup, J. C. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.10.004 · Cited by 207 · see citing works

Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy

Joza, N. A., Oudit, G. Y., Brown, D., Bénit, P., Kassiri, Z., Vahsen, N., Benoît, L. A., Patel, M. M., Nowikovsky, K., Vassault, A. J., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10261-10272.2005 · Cited by 206 · see citing works

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Skov, V., Glintborg, D., Knudsen, S., Jensen, T. E., Kruse, T. A., Tan, Q., Brusgaard, K., Beck‐Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db07-0275 · Cited by 202 · see citing works

Sequential Serum-dependent Activation of CREB and NRF-1 Leads to Enhanced Mitochondrial Respiration through the Induction of Cytochrome c

Herzig, R. P., Scacco, S., & Scarpulla, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13134 · Cited by 197 · see citing works

Ten-Year Experience with an Exercise-Based Outpatient Life-Style Modification Program in the Treatment of Diabetes Mellitus

Schneider, S. H., Khachadurian, A. K., Amorosa, L. F., Clemow, L., & Ruderman, N. B. (1992) · Diabetes Care · doi:10.2337/diacare.15.11.1800 · Cited by 195 · see citing works

Skeletal muscle histochemical and biochemical characteristics in sedentary male and female subjects

Simoneau, J. A., Lortie, G., Boulay, M. R., Thibault, M. C., Thériault, G., & Bouchard, C. (1985) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y85-005 · Cited by 190 · see citing works

III. Effects of Chronic Hypoxia on Muscle Enzyme Activities*

HOWALD, H., Pette, D., Simoneau, J. A., Uber, A., Hoppeler, H. H., & Cerretelli, P. (1990) · International Journal of Sports Medicine · doi:10.1055/s-2007-1024847 · Cited by 188 · see citing works

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

Nair, K. S., Bigelow, M. L., Asmann, Y. W., Chow, L. S., Coenen-Schimke, J. M., Klaus, K. A., Guo, Z.-K., Sreekumar, R., & Irving, B. A. (2008) · Diabetes · doi:10.2337/db07-1556 · Cited by 187 · see citing works

Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats

Raza, H., Prabu, S. K., Robin, M.-A., & Avadhani, N. G. (2004) · Diabetes · doi:10.2337/diabetes.53.1.185 · Cited by 186 · see citing works

Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance

Sack, M. N. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.07.010 · Cited by 185 · see citing works

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

Choi, C. S., Fillmore, J. J., Kim, J. K., Liu, Z., Kim, S., Collier, E. F., Kulkarni, A. S., Distefano, A. G., Hwang, Y.-J., Kahn, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci13579 · Cited by 182 · see citing works

Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies

Goldfine, A. B., Patti, M., Zuberi, L. M., Goldstein, B. J., LeBlanc, R., Landaker, E. J., Jiang, Z. Y., Willsky, G. R., & Kahn, C. R. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90418-9 · Cited by 182 · see citing works

Role of AMP Kinase and PPARδ in the Regulation of Lipid and Glucose Metabolism in Human Skeletal Muscle

Krämer, D. K., Al-Khalili, L., Guigas, B., Leng, Y., Garcia-Roves, P. M., & Krook, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702329200 · Cited by 180 · see citing works

Investigation of Heteroplasmy in the Human Mitochondrial DNA Control Region: A Synthesis of Observations from More Than 5000 Global Population Samples

Irwin, J. A., Saunier, J. L., Niederstätter, H., Strouss, K. M., Sturk‐Andreaggi, K., Diegoli, T. M., Kloss‐Brandstätter, A., Parson, W., & Parsons, T. J. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9227-4 · Cited by 180 · see citing works

Rosiglitazone and Cardiovascular Risk

Psaty, B. M., & Furberg, C. D. (2007) · New England Journal of Medicine · doi:10.1056/nejme078099 · Cited by 179 · see citing works

Effect of Exercise Intensity on Glucose and Insulin Metabolism in Obese Individuals and Obese NIDDM Patients

Kang, J., Robertson, R. J., Hagberg, J. M., Kelley, D. E., Goss, F. L., DaSilva, S. G., Suminski, R. R., Jr., & Utter, A. C. (1996) · Diabetes Care · doi:10.2337/diacare.19.4.341 · Cited by 177 · see citing works

Adipokines, Myokines and Cardiovascular Disease

Walsh, K. X. (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0961 · Cited by 177 · see citing works

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

Holloszy, J. O. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717c · Cited by 175 · see citing works

Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.

King, P. A., Horton, E. D., Hirshman, M. F., & Horton, E. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116025 · Cited by 172 · see citing works

Cobalt(II) and Cobalt(III) Dipicolinate Complexes: Solid State, Solution, and in Vivo Insulin-like Properties

Yang, L., Crans, D. C., Miller, S. M., la Cour, A., Anderson, O. P., Kaszynski, P. M., Godzala, M. E., Austin, L. T., & Willsky, G. R. (2002) · Inorganic Chemistry · doi:10.1021/ic020062l · Cited by 168 · see citing works

Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats.

Kahn, B. B., Rossetti, L., Lodish, H. F., & Charron, M. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115254 · Cited by 166 · see citing works

Insulin-like effects of vanadium: basic and clinical implications

Goldwaser, I., Gefel, D., Gershonov, E., Fridkin, M., & Shechter, Y. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)00035-0 · Cited by 166 · see citing works

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166 · see citing works

The PI3K/AKT Pathway in Obesity and Type 2 Diabetes

Huang, X., Liu, G., Guo, J., & Su, Z. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27173 · Cited by 1,673 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

Mechanisms of insulin resistance in obesity

Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699 · see citing works

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · see citing works

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 467 · see citing works

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 399 · see citing works

Mitochondrial dysfunction in metabolic syndrome

Prasun, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165838 · Cited by 375 · see citing works

Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity

Alam, M. A., Subhan, N., Hossain, H., Hossain, M., Reza, H. M., Rahman, M., & Ullah, M. O. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0080-3 · Cited by 372 · see citing works

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Chung, H. K., Ryu, D., Kim, K. S., Chang, J. Y., Kim, Y. K., Yi, H.-S., Kang, S. G., Choi, M. J., Lee, S. E., Jung, S.-B., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201607110 · Cited by 357 · see citing works

MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism

Han, L., Buchan, R. J., & Cook, S. A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq010 · Cited by 332 · see citing works

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

Yuzefovych, L., Wilson, G., & Rachek, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2010 · Cited by 280 · see citing works

OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance

Pereira, R. O., Tadinada, S. M., Zasadny, F. M., Oliveira, K. J., Pires, K. M. P., Olvera, A., Jeffers, J., Souvenir, R., Mcglauflin, R., Seei, A., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696179 · Cited by 211 · see citing works

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

Traba, J., Kwarteng-Siaw, M., Okoli, T. C., Li, J., Huffstutler, R. D., Bray, A., Waclawiw, M. A., Han, K., Pelletier, M., Sauve, A. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83260 · Cited by 180 · see citing works

Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes

Zhao, X., León, I. R., Bak, S. Y., Mogensen, M., Wrzesinski, K., Højlund, K., & Jensen, O. N. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.000299 · Cited by 169 · see citing works

Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle

Ljubicic, V., Miura, P., Burt, M., Boudreault, L., Khogali, S. E. O., Lunde, J. A., Renaud, J.-M., & Jasmin, B. J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr265 · Cited by 164 · see citing works

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works

Nitric oxide and mitochondria in metabolic syndrome

Litvinova, L. S., Atochin, D. N., Fattakhov, N. S., Василенко, М., Затолокин, П. А., & Кириенкова, Е. В. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00020 · Cited by 127 · see citing works

Mitochondria, the NLRP3 Inflammasome, and Sirtuins in Type 2 Diabetes: New Therapeutic TargetsReviewing Editors: Markus Bachschmid, Dylan Burger, Vittorio Calabrese, Amadou Camara, Lukas Kubala, Giuseppe Poli, and Chandan K. Sen

Rovira‐Llopis, S., Apostolova, N., Bañuls, C., Muntané, J., Rocha, M., & Víctor, V. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7313 · Cited by 120 · see citing works

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Sanches, J. M., Zhao, L. N., Salehi, A. A., Wollheim, C. B., & Kaldis, P. (2021) · FEBS Journal · doi:10.1111/febs.16306 · Cited by 125 · see citing works

Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes

Bakar, M. H. A., Sarmidi, M. R., Cheng, K., Khan, A. A., Suan, C. L., Huri, H. Z., & Yaakob, H. (2015) · Molecular BioSystems · doi:10.1039/c5mb00158g · Cited by 117 · see citing works

Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

Hu, F., & Liu, F. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.008 · Cited by 112 · see citing works

Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

Avila, C., Huang, R., Stevens, M., Aponte, A. M., Tripodi, D., Kim, K., & Sack, M. N. (2011) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0031-1285833 · Cited by 112 · see citing works

Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes

Henstridge, D. C., Whitham, M., & Febbraio, M. A. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.08.003 · Cited by 110 · see citing works

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

Hong, S., Zhou, W., Fang, B., Lu, W., Loro, E., Damle, M., Ding, G., Jager, J., Zhang, S., Zhang, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4245 · Cited by 110 · see citing works

The PI3K/Akt signaling axis and type 2 diabetes mellitus (T2DM): From mechanistic insights into possible therapeutic targets

Taheri, R., Mokhtari, Y., Yousefi, A., & Bashash, D. (2024) · Cell Biology International · doi:10.1002/cbin.12189 · Cited by 109 · see citing works

The role of sirtuins in modulating redox stressors

Webster, B. R., Lu, Z., Sack, M. N., & Scott, I. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.484 · Cited by 95 · see citing works

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus

Kulkarni, S. S., Salehzadeh, F., Fritz, T., Zierath, J. R., Krook, A., & Osler, M. E. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.014 · Cited by 94 · see citing works

Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: The roles of long chain fatty acids

Hafizi Abu Bakar, M., Kian Kai, C., Wan Hassan, W. N., Sarmidi, M. R., Yaakob, H., & Zaman Huri, H. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2601 · Cited by 91 · see citing works

Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver

Yao, J., Zhi, M., Gao, X., Hu, P., Li, C., & Yang, X. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20122551 · Cited by 85 · see citing works

Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works

Chronic Reduction of Plasma Free Fatty Acid Improves Mitochondrial Function and Whole-Body Insulin Sensitivity in Obese and Type 2 Diabetic Individuals

Daniele, G., Eldor, R., Merovci, A., Clarke, G. D., Xiong, J., Tripathy, D., Taranova, A. G., Abdul-Ghani, M. A., & DeFronzo, R. A. (2013) · Diabetes · doi:10.2337/db13-1130 · Cited by 83 · see citing works

Lactate and Risk of Incident Diabetes in a Case-Cohort of the Atherosclerosis Risk in Communities (ARIC) Study

Juraschek, S. P., Shantha, G. P. S., Chu, A. Y., Miller, E. R., Güallar, E., Hoogeveen, R. C., Ballantyne, C. M., Brancati, F. L., Schmidt, M. I., Pankow, J. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055113 · Cited by 77 · see citing works

Skeletal muscle morphology and contractile function in relation to muscle denervation in diabetic neuropathy

Allen, M. D., Major, B. P., Kimpinski, K., Doherty, T. J., & Rice, C. L. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01139.2013 · Cited by 77 · see citing works

Regulation of autophagy and mitophagy by nutrient availability and acetylation

Webster, B. R., Scott, I., Traba, J., Han, K., & Sack, M. N. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.02.001 · Cited by 73 · see citing works

Mechanism of insulin resistance in obesity: a role of ATP

Ye, J. (2021) · Frontiers of Medicine · doi:10.1007/s11684-021-0862-5 · Cited by 70 · see citing works

What Do Magnetic Resonance–Based Measurements of Pi→ATP Flux Tell Us About Skeletal Muscle Metabolism?

Kemp, G. J., & Brindle, K. M. (2012) · Diabetes · doi:10.2337/db11-1725 · Cited by 67 · see citing works

Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome

Aroor, A. R., Mandavia, C. H., Ren, J. T., Sowers, J. R., & Pulakat, L. (2012) · Cardiorenal Medicine · doi:10.1159/000335675 · Cited by 67 · see citing works

Effects of a Leucine and Pyridoxine-Containing Nutraceutical on Fat Oxidation, and Oxidative and Inflammatory Stress in Overweight and Obese Subjects

Zemel, M. B., & Bruckbauer, A. (2012) · Nutrients · doi:10.3390/nu4060529 · Cited by 67 · see citing works

Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity

Boudina, S., Sena, S., Sloan, C., Tebbi, A., Han, Y. H., O'Neill, B. T., Cooksey, R. C., Jones, D., Holland, W. L., McClain, D. A., et al. (2012) · Endocrinology · doi:10.1210/en.2011-2147 · Cited by 66 · see citing works

Prolonged Fasting Identifies Heat Shock Protein 10 as a Sirtuin 3 Substrate

Lu, Z., Chen, Y., Aponte, A. M., Battaglia, V., Guček, M., & Sack, M. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.606228 · Cited by 62 · see citing works

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis

Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62 · see citing works

Plasma lactate and diabetes risk in 8045 participants of the Atherosclerosis Risk in Communities Study

Juraschek, S. P., Selvin, E., Miller, E. R., Brancati, F. L., & Young, J. H. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.09.005 · Cited by 57 · see citing works

Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat

Warren, B. E., Lou, P., Lucchinetti, E., Zhang, L., Clanachan, A. S., Affolter, A., Hersberger, M., Zaugg, M., & Lemieux, H. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00511.2013 · Cited by 55 · see citing works

Mitochondria in metabolic disease: Getting clues from proteomic studies

Peinado, J. R., Díaz‐Ruiz, A., Frühbeck, G., & Malagón, M. M. (2013) · PROTEOMICS · doi:10.1002/pmic.201300376 · Cited by 57 · see citing works

MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women

Diamanti‐Kandarakis, E., Papalou, O., Kandaraki, E., & Kassi, G. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0616 · Cited by 55 · see citing works

Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation

Al-Rewashdy, H., Ljubicic, V., Lin, W., Renaud, J., & Jasmin, B. J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu535 · Cited by 52 · see citing works

Altered O-GlcNAc modification and phosphorylation of mitochondrial proteins in myoblast cells exposed to high glucose

Gu, Y., Ande, S. R., & Mishra, S. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.09.024 · Cited by 48 · see citing works

Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle

Lettieri‐Barbato, D., Cannata, S. M., Casagrande, V., Ciriolo, M. R., & Aquilano, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195912 · Cited by 48 · see citing works

Mitochondrial Inhibitor as a New Class of Insulin Sensitizer

Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47 · see citing works

Mechanisms of disease

Fernyhough, P., & McGavock, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00027-8 · Cited by 47 · see citing works

Mitochondrial Dynamics, Diabetes, and Cardiovascular Disease

García-Peña, L. M., Abel, E. D., & Pereira, R. O. (2024) · Diabetes · doi:10.2337/dbi23-0003 · Cited by 45 · see citing works

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Zhang, R. (2013) · Biology Open · doi:10.1242/bio.20134259 · Cited by 44 · see citing works

Increased skeletal muscle mitochondrial efficiency in rats with fructose-induced alteration in glucose tolerance

Crescenzo, R., Bianco, F., Coppola, P., Mazzoli, A., Cigliano, L., Liverini, G., & Iossa, S. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001566 · Cited by 42 · see citing works

In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (Gilg)

Oyedemi, S. O., Koekemoer, T., Bradley, G., van de Venter, M., & Afolayan, A. J. (2013) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-013-0120-8 · Cited by 43 · see citing works

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle

Yao, S., Yuan, Y., Zhang, H., Meng, X., Jin, L., Yang, J., Wang, W., Ning, G., Zhang, Y., & Zhang, Z. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.028 · Cited by 41 · see citing works

Markers of metabolic and cardiovascular health in adults: Comparative analysis of DEXA-based body composition components and BMI categories

Lang, P. O., Trivalle, C., Vogel, T., Proust, J., & Papazyan, J. P. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.03.010 · Cited by 41 · see citing works

NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism

Zhang, R., Hou, T., Cheng, H., & Wang, X. (2019) · The FASEB Journal · doi:10.1096/fj.201901117rr · Cited by 41 · see citing works

Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training

Toth, M. J., Miller, M. S., Ward, K. A., & Ades, P. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01591.2011 · Cited by 39 · see citing works

Mitochondrial Dysfunction: A Cellular and Molecular Hub in Pathology of Metabolic Diseases and Infection

Behl, T., Makkar, R., Anwer, M. K., Hassani, R., Khuwaja, G., Khalid, A., Mohan, S., Alhazmi, H. A., Sachdeva, M., & Rachamalla, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082882 · Cited by 38 · see citing works

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome

Traba, J., & Sack, M. N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2431-7 · Cited by 37 · see citing works

Mitochondrial phosphoproteomics of mammalian tissues

Kruse, R., & Højlund, K. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.004 · Cited by 35 · see citing works

Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity

Ballmann, C. G., Tang, Y., Bush, Z. D., & Rowe, G. C. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00209.2016 · Cited by 35 · see citing works

Lipoxins, resolvins, protectins, maresins and nitrolipids, and their clinical implications with specific reference to diabetes mellitus and other diseases: part II

Das, U. N. (2013) · Clinical Lipidology · doi:10.2217/clp.13.32 · Cited by 35 · see citing works

Low carbohydrate high fat ketogenic diets on the exercise crossover point and glucose homeostasis

Noakes, T. D., Prins, P., Volek, J. S., D’Agostino, D. P., & Koutnik, A. P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150265 · Cited by 35 · see citing works

Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low-protein diet

Claycombe, K., Roemmich, J. N., Johnson, L. K., Vomhof‐DeKrey, E. E., & Johnson, W. T. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.003 · Cited by 33 · see citing works

Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

Sadler, N., Angel, T. E., Lewis, M. P., Pederson, L. M., Chauvignè-Hines, L. M., Wiedner, S. D., Zink, E., Smith, R. D., & Wright, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047996 · Cited by 33 · see citing works

Diagnostic accuracy of triglyceride/glucose and triglyceride/HDL index as predictors for insulin resistance in children with and without obesity

Gómez‐García, A., Treviño, M. V. U., Sánchez, D. C. V., & Aguilar, C. Á. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.05.020 · Cited by 33 · see citing works

Mitochondrial destiny in type 2 diabetes: the effects of oxidative stress on the dynamics and biogenesis of mitochondria

Skuratovskaia, D., Komar, A., Vulf, M., & Litvinova, L. S. (2020) · PeerJ · doi:10.7717/peerj.9741 · Cited by 35 · see citing works

Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue

Jahansouz, C., Serrot, F. J., Frohnert, B. I., Foncea, R. E., Dorman, R. B., Slusarek, B., Leslie, D. B., Bernlohr, D. A., & Ikramuddin, S. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1708-5 · Cited by 32 · see citing works

Free fatty acid oxidation in insulin resistance and obesity.

Abel, E. D. (2010) · PubMed · Cited by 31 · see citing works

Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations

Liu, Z., Lim, C. Y., Su, M. Y.-F., Soh, S. L., Shui, G., Wenk, M. R., Grove, K. L., Radda, G. K., Han, W., & Xiao, X. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0111 · Cited by 31 · see citing works

Combination of 5‐aminolevulinic acid and ferrous ion reduces plasma glucose and hemoglobin A1c levels in Zucker diabetic fatty rats

Hara, T., Koda, A., Nozawa, N., Ota, U., Kondo, H., Nakagawa, H., Kamiya, A., Miyashita, K., Itoh, H., Nakajima, M., et al. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12048 · Cited by 29 · see citing works

Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy

da Silva, F. M., Esser, K. A., Murach, K. A., & Greene, N. P. (2023) · The Journal of Physiology · doi:10.1113/jp284808 · Cited by 28 · see citing works

MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE.

Abel, E. D. (2018) · Europe PMC (PubMed Central) · Cited by 27 · see citing works

Quercetin and Quercetin-Rich Red Onion Extract AlterPgc-1αPromoter Methylation and Splice Variant Expression

Devarshi, P. P., Jones, A., Taylor, E. M., Stefañska, B., & Henagan, T. M. (2017) · PPAR Research · doi:10.1155/2017/3235693 · Cited by 28 · see citing works

Mitochondrial DNA copy number and diabetes: the Atherosclerosis Risk in Communities (ARIC) study

DeBarmore, B. M., Longchamps, R. J., Zhang, Y., Kalyani, R. R., Güallar, E., Arking, D. E., Selvin, E., & Young, J. H. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001204 · Cited by 27 · see citing works

DNA damage in normal-weight obese syndrome measured by Comet assay

Tomasello, B., Malfa, G. A., Galvano, F., & Renis, M. (2010) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1007/s12349-010-0035-6 · Cited by 26 · see citing works

Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

Fraser, D. A., Hessvik, N. P., Nikolić, N., Aas, V., Hanssen, K. F., Bøhn, S. K., Thoresen, G. H., & Rustan, A. C. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0252-8 · Cited by 23 · see citing works

Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus‐31 magnetic resonance saturation transfer spectroscopy

Lim, E. L., Hollingsworth, K. G., Thelwall, P. E., & Taylor, R. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1519 · Cited by 23 · see citing works

FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance

Sun, Y., Yang, Z.-X., Ren, F., & Fang, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.186 · Cited by 22 · see citing works

Chronic Renal Failure, Cachexia, and Ghrelin

Laviano, A., Krznarić, Ž., Sánchez-Lara, K., Preziosa, I., Cascino, A., & Fanelli, F. R. (2010) · International Journal of Peptides · doi:10.1155/2010/648045 · Cited by 21 · see citing works

Interrelation of chemerin and TNF-α with mtDNA copy number in adipose tissues and blood cells in obese patients with and without type 2 diabetes

Skuratovskaia, D., Затолокин, П. А., Vulf, M., Mazunin, I., & Litvinova, L. S. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0485-8 · Cited by 21 · see citing works

Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics

Ohlendieck, K. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/893876 · Cited by 20 · see citing works

Raspberry supplementation reduces lipid accumulation and improves insulin sensitivity in skeletal muscle of mice fed a high-fat diet

Zou, T., Kang, Y., Wang, B., de Avila, J. M., You, J., Zhu, M. J., & Du, ‬. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103572 · Cited by 20 · see citing works

Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell

Kim, K., Choi, Y. K., Kim, M. J., Hwang, J. W., Min, K., Jung, S. Y., Kim, S.-K., Cho, Y.-W., & Cho, Y.-W. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0191 · Cited by 19 · see citing works

Mitochondrial DNA Copy Number: Linking Diabetes and Cancer

Memon, A. A., Vats, S., Sundquist, J., Li, Y., & Sundquist, K. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0100 · Cited by 19 · see citing works

Exercise improves skeletal muscle insulin resistance without reduced basal mTOR/S6K1 signaling in rats fed a high-fat diet

Liao, B., & Xu, Y. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1892-5 · Cited by 18 · see citing works

Effects of Calorie Restriction and Fiber Type on Glucose Uptake and Abundance of Electron Transport Chain and Oxidative Phosphorylation Proteins in Single Fibers from Old Rats

Wang, H., Arias, E. B., Yu, C. S., Verkerke, A. R. P., & Cartee, G. D. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx099 · Cited by 18 · see citing works

Profiling of human myotubes reveals an intrinsic proteomic signature associated with type 2 diabetes

Al‐Khalili, L., Barbosa, T. D. C., Östling, J., Massart, J., Katayama, M., Nyström, A., Oscarsson, J., & Zierath, J. R. (2013) · Translational Proteomics · doi:10.1016/j.trprot.2013.12.002 · Cited by 18 · see citing works

The role of autophagy in insulin resistance and glucolipid metabolism and potential use of autophagy modulating natural products in the treatment of type 2 diabetes mellitus

Yang, X., Ding, W., Chen, Z., Lai, K., & Liu, Y. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3762 · Cited by 17 · see citing works

Differences in the Triglyceride to HDL-Cholesterol Ratio between Palestinian and Israeli Adults

Weiss, R., Nassar, H., Sinnreich, R., & Kark, J. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116617 · Cited by 17 · see citing works

Relationships between plasma lactate, plasma alanine, genetic variations in lactate transporters and type 2 diabetes in the Japanese population

Higuchi, I., Kimura, Y., Kobayashi, M., Narumi, K., Furugen, A., Miyoshi, H., Nakamura, A., Yamada, T., Atsumi, T., & Iseki, K. (2019) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2019.10.001 · Cited by 17 · see citing works

The Mitochondrial Proteomic Signatures of Human Skeletal Muscle Linked to Insulin Resistance

Kruse, R., Sahebekhtiari, N., & Højlund, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155374 · Cited by 18 · see citing works

Impact of dyslipidemia in the development of cardiovascular complications: Delineating the potential therapeutic role of coenzyme Q10

Mthembu, S. X. H., Orlando, P., Silvestri, S., Ziqubu, K., Mazibuko-Mbeje, S. E., Mabhida, S. E., Nyambuya, T. M., Nkambule, B. B., Muller, C. J. F., Basson, A. K., et al. (2022) · Biochimie · doi:10.1016/j.biochi.2022.08.018 · Cited by 18 · see citing works

Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice

Yeon, M., Seo, E., Lee, J., & Jun, H. (2023) · Antioxidants · doi:10.3390/antiox12010137 · Cited by 17 · see citing works

Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

Dankel, S. N., Staalesen, V., Bjørndal, B., Berge, R. K., Mellgren, G., & Burri, L. (2011) · Journal of Obesity · doi:10.1155/2011/435245 · Cited by 16 · see citing works

Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetes

Lim, E. L., Hollingsworth, K. G., Smith, F. E., Thelwall, P. E., & Taylor, R. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2011 · Cited by 16 · see citing works

Insulin resistance and mitochondrial function in skeletal muscle

Dela, F., & Helge, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.019 · Cited by 53 · see citing works

The role of mitochondrial function in skeletal muscle insulin resistance

Zhang, K., & Du, J. (2011) · Intern J Endocrinol Metab · doi:10.3760/cma.j.issn.1673-4157.2011.05.010

Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Højlund, K., Mogensen, M., Sahlin, K., & Beck-Nielsen, H. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.006 · Cited by 135 · see citing works

KS: Skeletal muscle mitochondrial dysfunction & diabetes

Sreekumar, R., & Nair, K. S. (2015)

Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?

Genders, A. J., Holloway, G. P., & Bishop, D. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186948 · Cited by 51 · see citing works