Cited by 101Mindfulness and Compassion InterventionsNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique

Bujatti, M., Biederer, P.·1976·Journal of Neural Transmission

Abstract

The highly significant increase of 5-HIAA (5-hydroxyindole-3-acetic acid) in Transcendental Meditation technique suggests systemic serotonin as "rest and fulfillment hormone" of deactivation-relaxation. Furthermore 5-HT (5-hydroxytryptamine, serotonin) is considered to be the EC-cell (enterochromaffine-cell) hormone requested by Fujita and Kobayashi and its role for EEG synchronisation via area postrema chemoreceptor as anti arousal agent is being discussed. The significant decrease of the catecholamine metabolite VMA (vanillic-mandelic acid) in meditators, that is associated with a reciprocal increase of 5-HIAA supports as a feedback necessity the "rest and fulfillment response" versus "fight and flight". As the adreno medullary tissue serves for hormonal reinforcement of orthosympathetic activity, the Enterochromaffine Cell System (having taken the form of distinct organs in some species as octopus and discoglossus) is suggested to serve via serotonin for humoral reinforcement of parasympathetic activity in deep relaxation.

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  • Increases in wake-related or sleep-inhibiting neurotransmitters such as norepinephrine, dopamine, and serotonin have been found in studies of non-Buddhist meditation, though the relationship between peripheral and brain levels is unclear.

    “Increases in wake-related/sleep-inhibiting neurotransmitters, such as norepinephrine,16,26,47,112, 113 dopamine,114 and serotonin,77,115–118 have been found in studies of non-Buddhist forms of meditation, although the relationship between peripheral and brain levels is unclear.”

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Authors
Bujatti, M., & Biederer, P.
Venue
Journal of Neural Transmission
Published
1976-09
Volume
39
Issue
3
Pages
257-267
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2082566411
Cited by
101
References
40
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 1
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
transcendental meditation, serotonin, norepinephrine, dopamine metabolites, 5-hydroxyindoleacetic acid, enterochromaffin cells, catecholamine metabolites, deep relaxation, fight-or-flight response, parasympathetic activity
MeSH terms
Adult, Circadian Rhythm, Dopamine, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Indoleacetic Acids, Male, Middle Aged, Norepinephrine, Relaxation Therapy, Serotonin, Vanilmandelic Acid

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