Methylphenidate and hospitalized adolescents with conduct disorder: dose effects on classroom behavior, academic performance and impulsivity
Abstract
The effects of methylphenidate on hospitalized conduct-disordered (CD) adolescents were examined by using teacher ratings of behavior, a measure of classroom learning, and a test of impulsivity. Twenty-two male adolescents with CD, 12-18 years of age, participated in a double-blind, placebo-controlled, within-subject (crossover) design in which each adolescent received three doses of methylphenidate (10 mg, 15 mg, and 20 mg) and a placebo in a randomly assigned, counterbalanced order. Seven of the adolescents had a comorbid diagnosis of attention deficit hyperactivity disorder. Significant overall medication effects were shown on teacher ratings of conduct, and on number of arithmetic questions correctly completed and time spent. Within the limitations of this study, stimulant actions may be effective for some aspects of CD in the absence of attention deficit hyperactivity disorder, although only for specific measures.
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Initial studies suggest that methylphenidate also has an impact on emotional dysregulation behaviors in ASPD and CD as well as BPD.
“This idea is in line with initial studies, suggesting that methylphenidate also has an impact on emotional dysregulation behaviors in ASPD and CD (Kaplan et al., 1990; Brown et al., 1991; Klein et al., 1997; Connor et al., 2000) as well as BPD (Schulz et al., 1988; Golubchik et al., 2008; Prada et al., 2015; although see Schulz et al. (1988) for possible issue with schizotypal comorbidity).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Brown et al., 1991
Cites
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DSM-III field trials: I. Initial interrater diagnostic reliability
(1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.6.815 · Cited by 394 · see citing works
Hechtman, L., & Weiss, G. (1986) · The Canadian Journal of Psychiatry · doi:10.1177/070674378603100614 · Cited by 156 · see citing works
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Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Storebø, O. J., Ramstad, E., Krogh, H. B., Nilausen, T. D., Skoog, M., Holmskov, M., Rosendal, S., Groth, C., Magnusson, F. L., Moreira-Maia, C. R., et al. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009885.pub2 · Cited by 347 · see citing works
Top-Down Dysregulation—From ADHD to Emotional Instability
Petrovic, P., & Castellanos, F. X. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00070 · Cited by 179 · see citing works
“…and emotional instability disorders such as BPD, ASPD and CD. has an impact on emotional dysregulation behaviors in ASPD and CD (Kaplan et al., 1990; Brown et al., 1991; Klein et al., 1997; Connor et al., 2000) as well as BPD (Schulz et al., 1988; Golubchik et al., 2008; Prada et al., 2015;…”
Background
- Authors
- Brown, R. T., Jaffe, S. L., Silverstein, J., & Magee, H.
- Affiliations
- Emory University (US)
- ORCID
- Brown, Ronald T.
- Venue
- Journal of Youth and Adolescence
- Published
- 1991-10
- Volume
- 20
- Issue
- 5
- Pages
- 501-518
- ISSN
- 0047-2891 (ISSN-L)
- 1573-6601
- OpenAlex
- W2065657107
- Cited by
- 10
- References
- 3
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Youth and Adolescence (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- methylphenidate, conduct disorder, hospitalized adolescents, stimulant medication, dose-response relationship, classroom behavior, academic performance, impulsivity, ADHD comorbidity, teacher ratings, arithmetic performance
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