Cyclic peptides and depsipeptides from cyanobacteria: A review
Open accessAbstract
An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates. Most of these cyclic peptides and depsipeptides, such as the microcystins and the lyngbyatoxins, will probably only be useful as biochemical research tools. A few, however, have the potential for development into useful commercial products. For example, cryptophycin-1, a novel inhibitor of microtubule assembly from Nostoc sp GSV 224, shows impressive activity against a broad spectrum of solid tumors implanted in mice, including multidrug-resistant ones, and majusculamide C, a microfilament-depolymerizing agent from Lyngbya majuscula, shows potent fungicidal activity and may have use in the treatment of resistant fungal-induced diseases of domestic plants and agricultural crops.
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Microalgae in modern cancer therapy: current knowledge
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Pharmaceutical applications of cyanobacteria—A review
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Biotechnological significance of toxic marine dinoflagellates
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Harnessing the potential: Advances in cyanobacterial natural product research and biotechnology
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- Authors
- Moore, R. E.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Corresponding author
- Moore, R E
- Venue
- Journal of Industrial Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02
- Volume
- 16
- Issue
- 2
- Pages
- 134-143
- ISSN
- 1367-5435 (ISSN-L)
- 0169-4146
- 1476-5535
- OpenAlex
- W2079620945
- Cited by
- 277
- References
- 88
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 13 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 11 · 2013: 16 · 2012: 8
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Industrial Microbiology & Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health (5r01ca012623-29)
- National Cancer Institute (CA12623, CA-53001)
- Division of Chemistry
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
- Keywords
- cyclic peptides, depsipeptides, cyanobacteria, microcystins, microtubule assembly inhibitors, antifungal activity, marine invertebrate natural products, Lyngbya majuscula, Nostoc
- MeSH terms
- Cyanobacteria, Amino Acid Sequence, Animals, Antifungal Agents, Antineoplastic Agents, Molecular Sequence Data, Neoplasms, Experimental, Peptides, Cyclic, Structure-Activity Relationship, Mice
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