Cited by 277Microbial Natural Products and BiosynthesisAquatic Ecosystems and Phytoplankton DynamicsBiocrusts and Microbial Ecology

Cyclic peptides and depsipeptides from cyanobacteria: A review

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Moore, R E·1996·Journal of Industrial Microbiology

Abstract

An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria). Several of these compounds possess structures that are similar to those of natural products from marine invertebrates. Most of these cyclic peptides and depsipeptides, such as the microcystins and the lyngbyatoxins, will probably only be useful as biochemical research tools. A few, however, have the potential for development into useful commercial products. For example, cryptophycin-1, a novel inhibitor of microtubule assembly from Nostoc sp GSV 224, shows impressive activity against a broad spectrum of solid tumors implanted in mice, including multidrug-resistant ones, and majusculamide C, a microfilament-depolymerizing agent from Lyngbya majuscula, shows potent fungicidal activity and may have use in the treatment of resistant fungal-induced diseases of domestic plants and agricultural crops.

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Research works printed but not linked: 2

  1. Wilkinson CR. 1979. Nutrient translocation from symbiotic cyanobac- teria to coral reef sponges. In: Biologie de Spongiaires (Sponge Biology) Vol 291 (Levi C and N Boury Esnault, eds), pp 373-380, Colloq Internat CNRS, Paris.
  2. Yu S-Z. 1989. Drinking water and primary liver cancer. In: Primary Liver Cancer (Tang ZY, MC Wu and SS Xia, eds), pp 30-37, Springer-Verlag, Berlin/Heidelberg.

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Authors
Moore, R. E.
Affiliations
University of Hawaiʻi at Mānoa (US)
Corresponding author
Moore, R E
Venue
Journal of Industrial Microbiology
Published
1996-02
Volume
16
Issue
2
Pages
134-143
ISSN
  • 1367-5435 (ISSN-L)
  • 0169-4146
  • 1476-5535
OpenAlex
W2079620945
Cited by
277
References
88
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 13 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 11 · 2013: 16 · 2012: 8
FWCI
7.24
Type
journal article
Language
en
Open access
Locations
  • Journal of Industrial Microbiology & Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (5r01ca012623-29)
  • National Cancer Institute (CA12623, CA-53001)
  • Division of Chemistry
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
Keywords
cyclic peptides, depsipeptides, cyanobacteria, microcystins, microtubule assembly inhibitors, antifungal activity, marine invertebrate natural products, Lyngbya majuscula, Nostoc
MeSH terms
Cyanobacteria, Amino Acid Sequence, Animals, Antifungal Agents, Antineoplastic Agents, Molecular Sequence Data, Neoplasms, Experimental, Peptides, Cyclic, Structure-Activity Relationship, Mice

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