Calothrixins A and B, novel pentacyclic metabolites from Calothrix cyanobacteria with potent activity against malaria parasites and human cancer cells
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Human Malaria Parasites in Continuous Culture
Trager, W. F., & Jensen, J. B. (1976) · Science · doi:10.1126/science.781840 · Cited by 7,887 · see citing works
Carmichael, J., DeGraff, W., Gazdar, A. F., Minna, J. D., & Mitchell, J. B. (1987) · PubMed · Cited by 3,813 · see citing works
Chemistry of Heterocyclic Compounds
(1971) · The chemistry of heterocyclic compounds/The Chemistry of heterocyclic compounds · doi:10.1002/9780470186886 · Cited by 2,450 · see citing works
Studies in Natural Products Chemistry
(1993) · Studies in natural products chemistry · doi:10.1016/b978-0-444-89366-6.70001-0 · Cited by 1,743 · see citing works
A Plastid of Probable Green Algal Origin in Apicomplexan Parasites
Köhler, S., Delwiche, C., Denny, P., Tilney, L., Webster, P., Wilson, R. J. M., Palmer, J., & Roos, D. (1997) · Science · doi:10.1126/science.275.5305.1485 · Cited by 770 · see citing works
Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity
Makler, M. T., Ries, J. M., Williams, J. A., et al. (1993) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1993.48.739 · Cited by 750 · see citing works
A plastid organelle as a drug target in apicomplexan parasites
Fichera, M., & Roos, D. (1997) · Nature · doi:10.1038/37132 · Cited by 605 · see citing works
Plumb, J. A., Milroy, R., & Kaye, S. B. (1989) · PubMed · Cited by 584 · see citing works
Microalgae as sources of pharmaceuticals and other biologically active compounds
Borowitzka, M. A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003544 · Cited by 520 · see citing works
Antimalarial drug resistance: the pace quickens
White, N. J. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/30.5.571 · Cited by 281 · see citing works
Cyclic peptides and depsipeptides from cyanobacteria: A review
Moore, R. E. (1996) · Journal of Industrial Microbiology · doi:10.1007/bf01570074 · Cited by 277 · see citing works
An alternative to serum for cultivation of Plasmodium falciparum in vitro
Cranmer, S. L., Magowan, C., Liang, J. N., Coppel, R. L., & Cooke, B. M. (1997) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(97)90110-3 · Cited by 211 · see citing works
Structure Elucidation by NMR in Organic Chemistry
Breitmaier, E. (2002) · Wiley eBooks · doi:10.1002/0470853069 · Cited by 187 · see citing works
ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA)1
Patterson, G. M. L., Baldwin, C. L., Bolis, C. M., Caplan, F. R., Karuso, H., Larsen, L. K., Levine, I. A., Moore, R. E., Nelson, C. S., Tschappat, K. D., et al. (1991) · Journal of Phycology · doi:10.1111/j.0022-3646.1991.00530.x · Cited by 113 · see citing works
Schlegel, I., Doan, N. T., de Chazal, N. M., & Smith, G. D. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008042619686 · Cited by 112 · see citing works
Self-citationCytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the nostocaceae.
Knübel, G., Larsen, L. K., Moore, R. E., Levine, I. A., & Patterson, G. M. L. (1990) · The Journal of Antibiotics · doi:10.7164/antibiotics.43.1236 · Cited by 104 · see citing works
Calophycin, a fungicidal cyclic decapeptide from the terrestrial blue-green alga Calothrix fusca
Moon, S., Chen, J. L., Moore, R. E., & Patterson, G. M. L. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00030a013 · Cited by 87 · see citing works
In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines
Wagner, M. M. F., Paul, D. C., Shih, C., Jordan, M. A., Wilson, L., & Williams, D. C. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050871 · Cited by 87 · see citing works
A Survey of Indolo [2,3-a] carbazole Alkaloids and Related Natural Products
Gribble, G. W., & Berthel, S. J. (1993) · Studies in natural products chemistry · doi:10.1016/b978-0-444-89366-6.70015-0 · Cited by 58 · see citing works
Science, medicine, and the future : malaria
Krishna, S. (1997) · BMJ · doi:10.1136/bmj.315.7110.730 · Cited by 15 · see citing works
Duffield, A. M., Buchardt, O., Samuelson, O., et al. (1972) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.26-2423 · Cited by 15 · see citing works
Kaiya, T., Shirai, N., & Kawazoe, Y. (1986) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.34.881 · Cited by 12 · see citing works
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Sorted by citations
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
“Calothrixins A and B, are pentacyclic metabolites isolated from Calothrix cyanobacteria with anticancer potent activity against human HeLa cancer cells in a dose-dependent manner at an IC50 of 40 and 350 nM, respectively (in vitro studies) [89].”
BackgroundImmense essence of excellence: Marine microbial bioactive compounds
Bhatnagar, I., & Kim, S.-K. (2010) · Marine Drugs · doi:10.3390/md8102673 · Cited by 384 · see citing works
Berry, J., Gantar, M., Perez, M., Berry, G., & Noriega, F. (2008) · Marine Drugs · doi:10.3390/md6020117 · Cited by 231 · see citing works
Microalgae in modern cancer therapy: current knowledge
Abd El-Hack, M. E., Abdelnour, S., Alagawany, M., Abdo, M., Sakr, M. A., Khafaga, A. F., Mahgoub, S. A., Elnesr, S. S., & Gebriel, M. G. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.069 · Cited by 206 · see citing works
Pharmaceutical applications of cyanobacteria—A review
Vijayakumar, S., & Menakha, M. (2015) · Journal of Acute Medicine · doi:10.1016/j.jacme.2015.02.004 · Cited by 205 · see citing works
Mansouramycins A–D, cytotoxic isoquinolinequinones from a marine Streptomycete
Hawas, U. W., Shaaban, M., Shaaban, K. A., Speitling, M., Maier, A., Kelter, G., Fiebig, H. H., Meiners, M., Helmke, E., & Laatsch, H. (2009) · Journal of Natural Products · doi:10.1021/np900160g · Cited by 116 · see citing works
Cyanobacteria and microalgae: A renewable source of bioactive compounds and other chemicals
Encarnação, T., Pais, A. A. C. C., Campos, M. G., & Burrows, H. D. (2015) · Science Progress · doi:10.3184/003685015x14298590596266 · Cited by 65 · see citing works
- Authors
- Rickards, R. W., Rothschild, J. M., Willis, A. C., de Chazal, N. M., Kirk, J., Kirk, K., Saliba, K. J., & Smith, G. D.
- Affiliations
- Australian National University (AU)
- Corresponding author
- Rickards, Rodney W.
- Smith, Geoffrey D.
- Venue
- Tetrahedron
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 55
- Issue
- 47
- Pages
- 13513-13520
- ISSN
- 0040-4020 (ISSN-L)
- OpenAlex
- W2032337080
- Cited by
- 249
- References
- 22
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 18 · 2021: 14 · 2020: 14 · 2019: 11 · 2018: 17 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 14
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Synthesis and bioactivity of alkaloids
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Keywords
- Plasmodium falciparum, chloroquine resistance, anticancer activity, bioassay-guided fractionation, structure elucidation
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