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Cited by 50Breast Cancer Treatment StudiesBreast Lesions and CarcinomasIron Metabolism and Disorders

Tissue ferritin concentration and prognosis in carcinoma of the breast

Weinstein, Robert E., Bond, Bernice H., Silberberg, Boris K., Vaughn, Clarence B., Subbaiah, Perla, Pieper, David R.·1989·Breast Cancer Research and Treatment
DOI 10.1007/bf01806307
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Abstract

Seven year follow-up data were available on 36 of 40 breast carcinoma patients in whom breast tissue ferritin concentrations at the time of surgery were known. 18 patients were alive and free of recurrence or second tumor (Group 1) and 11 died with breast cancer (Group 2). Patients with lower tissue ferritin concentrations defined as less than 319 ng/mcp (nanograms of ferritin/milligram of cytosol protein) were at reduced risk: 86% of patients with low tissue ferritin concentration survived free of recurrence or second tumor vs. 40% of patients with high tissue ferritin concentration (P = 0.0056). Mean breast carcinoma tissue ferritin concentration was 295 +/- 52 ng/mcp in Group 1 and 444 +/- 55 ng/mcp in Group 2 (P = 0.036). Lymph node involvement was predictive of mortality from breast carcinoma (P = 0.0003), but did not correlate with mean tissue ferritin concentration (P = 0.082). 10/10 (100%) patients who had both low tissue ferritin concentration and absence of lymph node involvement were in Group 1. The correlation of breast tissue ferritin concentration with histopathologic dedifferentiation and with prognosis suggests tumor tissue ferritin as a marker of malignant potential.

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Crossref · 10.1007/bf01806307

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  • Expression of FT is considered a prognostic marker for some cancer subtypes such as squamous cell carcinoma or breast cancer.

    “For this reason, the expression of FT is considered a prognostic marker for some cancer subtypes such as squamous cell carcinoma or breast cancer [27,36,37].”

    From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [37]

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Related

Authors
Weinstein, R. E., Bond, B. H., Silberberg, B. K., Vaughn, C. B., Subbaiah, P., & Pieper, D. R.
Affiliations
  • Providence Hospital (US)
  • Henry Ford Hospital (US)
  • Oakland University (US)
ORCID
Pieper, David R.
Venue
Breast Cancer Research and Treatment
Publisher
Springer Science and Business Media LLC
Published
1989-12
Volume
14
Issue
3
Pages
349-353
ISSN
  • 0167-6806 (ISSN-L)
  • 1573-7217
DOI
10.1007/bf01806307
OpenAlex
W2037423513
Cited by
50
References
45
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Breast Cancer Research and Treatment (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
breast cancer, prognostic factors, tumor recurrence, lymph node involvement, survival, malignant potential, tumor markers
MeSH terms
Breast Neoplasms, Female, Ferritins, Humans, Middle Aged, Prognosis

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