Chemistry and biology of ferritin

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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EMT: 2016

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Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332 · see citing works

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084 · see citing works

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899 · see citing works

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature · doi:10.1038/nature24297 · Cited by 1,799 · see citing works

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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Diabetes is a risk factor for the progression and prognosis of <scp>COVID</scp>‐19

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Epigenetic plasticity and the hallmarks of cancer

Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works

The chemical basis of ferroptosis

Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,027 · see citing works

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Park, E., & Chung, S. W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2064-5 · Cited by 897 · see citing works

Ferritins: A family of molecules for iron storage, antioxidation and more

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Serum ferritin: Past, present and future

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Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

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Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Mai, T. T., Hamaï, A., Hienzsch, A., Cañeque, T., Müller, S., Wicinski, J., Cabaud, O., Leroy, C., David, A., Acevedo, V., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2778 · Cited by 612 · see citing works

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Brown, C. W., Amante, J. J., Chhoy, P., Elaimy, A. L., Liu, H., Zhu, L. J., Baer, C. E., Dixon, S. J., & Mercurio, A. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.10.007 · Cited by 582 · see citing works

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, M., Minagawa, S., Araya, J., Sakamoto, T., Hara, H., Tsubouchi, K., Hosaka, Y., Ichikawa, A., Saito, N., Kadota, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10991-7 · Cited by 572 · see citing works

Laboratory diagnosis of iron-deficiency anemia: An overview

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Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

Li, L., Fang, C. J., Ryan, J. C., Niemi, E. C., Lebrón, J. A., Björkman, P. J., Arase, H., Torti, F. M., Torti, S. V., Nakamura, M. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913192107 · Cited by 558 · see citing works

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Mancias, J. D., Pontano Vaites, L., Nissim, S., Biancur, D. E., Kim, A. J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A. C., & Harper, J. W. (2015) · eLife · doi:10.7554/elife.10308 · Cited by 552 · see citing works

A cytosolic iron chaperone that delivers iron to ferritin

Shi, H., Bencze, K. Z., Stemmler, T. L., & Philpott, C. C. (2008) · Science · doi:10.1126/science.1157643 · Cited by 536 · see citing works

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

Chen, G., Benthani, F. A., Wu, J., Liang, D., Bian, Z., & Jiang, X. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0352-3 · Cited by 512 · see citing works

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

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Ferritin, cellular iron storage and regulation

Arosio, P., Elia, L., & Poli, M. (2017) · IUBMB Life · doi:10.1002/iub.1621 · Cited by 480 · see citing works

Iron addiction: a novel therapeutic target in ovarian cancer

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

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Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

Cohen, L. A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.-L., Crooks, D. R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M. W., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253815 · Cited by 452 · see citing works

Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases

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Iron and Cancer

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The role of NCOA4-mediated ferritinophagy in health and disease

Santana-Codina, N., & Mancias, J. D. (2018) · Pharmaceuticals · doi:10.3390/ph11040114 · Cited by 410 · see citing works

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

Fuhrmann, D. C., Mondorf, A. W., Beifuß, J., Jung, M., & Brüne, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101670 · Cited by 409 · see citing works

Ferritin: A Versatile Building Block for Bionanotechnology

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Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Cheng, L., Li, H., Li, L., Liu, C., Yan, S., Chen, H., & Li, Y. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23618 · Cited by 390 · see citing works

Global transcriptome analyses of human and murine terminal erythroid differentiation

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Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

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PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Gentric, G., Kieffer, Y., Mieulet, V., Goundiam, O., Bonneau, C., Némati, F., Hurbain, I., Raposo, G., Popova, T. G., Stern, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.002 · Cited by 311 · see citing works

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

Ashraf, A., Jeandriens, J., Parkes, H. G., & So, P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101494 · Cited by 304 · see citing works

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

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CD44 regulates epigenetic plasticity by mediating iron endocytosis

Müller, S., Sindikubwabo, F., Cañeque, T., Lafon, A., Versini, A., Lombard, B., Loew, D., Wu, T., Ginestier, C., Charafe‐Jauffret, E., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-0513-5 · Cited by 296 · see citing works

Engineered Protein Cages for Nanomaterial Synthesis

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PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

Li, C., Zhang, Y., Cheng, X., Yuan, H., Zhu, S., Liu, J., Wen, Q., Xie, Y., Liu, J., Kroemer, G., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.012 · Cited by 258 · see citing works

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

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Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

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Screening for iron deficiency: an analysis based on bone‐marrow examinations and serum ferritin determinations in a population sample of women

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Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease

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Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome

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Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease

Ueda, N., & Takasawa, K. (2018) · Nutrients · doi:10.3390/nu10091173 · Cited by 234 · see citing works

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

Quiles del Rey, M., & Mancias, J. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00238 · Cited by 227 · see citing works

Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells

Perez, M. A., Magtanong, L., Dixon, S. J., & Watts, J. L. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.019 · Cited by 225 · see citing works

Ferritin is secreted via 2 distinct nonclassical vesicular pathways

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Role of ferritin alterations in human breast cancer cells

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Serum ferritin as an independent risk factor for severity in COVID-19 patients

Lin, Z., Long, F., Yang, Y., Chen, X., Xu, L., & Yang, M. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.06.053 · Cited by 200 · see citing works

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

Muhoberac, B. B., & Vidal, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01195 · Cited by 196 · see citing works

Ferritin family proteins and their use in bionanotechnology

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Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

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Ferritin in autoimmune diseases

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The release of iron from horse spleen ferritin by reduced flavins

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Influence of Age on Characteristics of Polymyositis and Dermatomyositis in Adults

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Mitochondrial Ferritin: A New Player in Iron Metabolism

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Visualizing biologically active small molecules in cells using click chemistry

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Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

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A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells

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Mouse brains deficient in H‐ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

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Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

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Human Mitochondrial Ferritin Expressed in HeLa Cells Incorporates Iron and Affects Cellular Iron Metabolism

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Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

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Ferritins for chemistry and for life

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Multiple Pathways for Mineral Core Formation in Mammalian Apoferritin. The Role of Hydrogen Peroxide

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Iron: the cancer connection

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Metal–peptide rings form highly entangled topologically inequivalent frameworks with the same ring- and crossing-numbers

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A PCBP1–BolA2 chaperone complex delivers iron for cytosolic [2Fe–2S] cluster assembly

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Release of iron from ferritin by xanthine oxidase. Role of the superoxide radical

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Regulated secretion of glycosylated human ferritin from hepatocytes

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Serum ferritin and isoferritins are tools for diagnosis of active adult Still's disease.

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Nuclear ferritin: A new role for ferritin in cell biology

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Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

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The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement

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The purification and properties of ferritin from human serum

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Facilitated Diffusion of Iron(II) and Dioxygen Substrates into Human H-Chain Ferritin. A Fluorescence and Absorbance Study Employing the Ferroxidase Center Substitution Y34W

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The Structure of Ferritin Cores Determined by Electron Nanodiffraction

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Nuclear Ferritin Protects DNA From UV Damage in Corneal Epithelial Cells

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Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains

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Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance

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Iron-Induced Oxidative Stress in Human Diseases

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Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications

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Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

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Metal Ion Signaling in Biomedicine

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Ferroptosis in Parkinson's disease —— The iron-related degenerative disease

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METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer

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Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression

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Pulling back the mitochondria’s iron curtain

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Cancer: The role of iron and ferroptosis

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Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis

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Minerals and Cancer: Overview of the Possible Diagnostic Value

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Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis

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The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?

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Copper and iron orchestrate cell-state transitions in cancer and immunity

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Advances in Fluorescence Techniques for the Detection of Hydroxyl Radicals near DNA and Within Organelles and Membranes

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Iron metabolism dysregulation and ferroptosis: Emerging drivers in pulmonary fibrosis pathogenesis and therapy

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COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters

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Exploring Predictive and Prognostic Biomarkers in Colorectal Cancer: A Comprehensive Review

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Defining Global Thresholds for Serum Ferritin: A Challenging Mission in Establishing the Iron Deficiency Diagnosis in This Era of Striving for Health Equity

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Haem Oxygenase-1, Ferroptosis and Disorders—A Narrative Review

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Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology

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Modeling the iron storage protein ferritin reveals how residual ferrihydrite iron determines initial ferritin iron sequestration kinetics

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Curculigoside exhibits multiple therapeutic efficacy to induce apoptosis and ferroptosis in osteosarcoma via modulation of ROS and tumor microenvironment

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Unveiling the intersection: ferroptosis in influenza virus infection

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Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice

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Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4

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Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis

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Identification of Serum Ferritin-Specific Nanobodies and Development towards a Diagnostic Immunoassay

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The application of ferritin in transporting and binding diverse metal ions

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Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia

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Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD

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Assessing the metronidazole adsorption by an iron-enhanced nanocone along with DFT calculations regarding the conjugated system formations for developing the drug delivery platforms

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Nanovaccines: Antigen selection, stabilization, adjuvantation, formulation, and evaluation

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Ferroptosis and its current progress in gastric cancer

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Iron links endogenous and exogenous nanoparticles

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Autophagy mediated FTH1 degradation activates gasdermin E dependent pyroptosis contributing to diquat induced kidney injury

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Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

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N4-acetylcytidine-mediated SOAT1 upregulation aggravates heart failure by inducing NCOA4-dependent ferroautophagy and ferroptosis in cardiomyocytes

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Protein-Based Nanocarriers and Nanotherapeutics for Infection and Inflammation

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Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation

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Tirzepatide Induces Ferroptosis in Glioblastoma Cell Lines via the SOX2/SLC7A11 Axis: A Potential Therapeutic Strategy for Glioma Treatment

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Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions

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Lower serum ferritin levels are associated with worse cognitive performance in aging

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Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study

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Emerging and Dynamic Biomedical Uses of Ferritin

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Ferritin

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A novel view of ferritin in cancer

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