The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Place conditioning with dopamine D1 and D2 agonists injected peripherally or into nucleus accumbens
Abstract
The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within each experimental group, half the rats received drug pairings in each choice compartment. Intraperitoneal injections of SKF38393 produced conditioned place aversions at all doses tested (1.0-4.0 mg/kg); LY171555 produced weak conditioned place preferences at 1.0 and 2.0 mg/kg, but no reliable effect at 4.0 mg/kg. Bilateral intra-accumbens microinjections of SKF38393 produced strong preferences at all doses tested (0.5-2.0 micrograms/side); LY171555 produced strong preferences at two doses (0.5 and 1.0 micrograms/side) and no effect at a third dose (2.0 micrograms/side). These results suggest that activation of either D1 or D2 receptors in the nucleus accumbens can produce reward, and that D1 receptors (and possibly also D2 receptors) located elsewhere in the brain or in the periphery may mediate aversive effects.
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“Intra-accumbens administration of amphetamine or dopamine receptor agonists also induces conditioned place preference”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as White et al., 1991
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Cites
The Rat Brain in Stereotaxic Coordinates
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D 1 Dopamine Receptor Activation Required for Postsynaptic Expression of D 2 Agonist Effects
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Dopaminergic substrates of amphetamine-induced place preference conditioning
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Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor
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Conditioned place preference from intra-accumbens but not intra-caudate amphetamine injections
Carr, G. D., & White, N. M. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90165-0 · Cited by 275
Self-citationCarr, G. D., & White, N. M. (1986) · Psychopharmacology · doi:10.1007/bf00174372 · Cited by 217
Self-citation
Research works printed but not linked: 4
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
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Metadata
- Authors
- White, N. M., Packard, M. G., & Hiroi, N.
- Affiliations
- McGill University (CA)
- Venue
- Psychopharmacology
- Published
- 1991-02
- Volume
- 103
- Issue
- 2
- Pages
- 271-276
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1972281490
- Cited by
- 148
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2022: 8 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- conditioned place preference, conditioned place aversion, dopamine D1 receptor, dopamine D2 receptor, SKF 38393, quinpirole, nucleus accumbens, intracerebral microinjection, intraperitoneal injection, reward, aversive effects
- MeSH terms
- Amphetamine, Animals, Conditioning, Operant, Dose-Response Relationship, Drug, Ergolines, Injections, Male, Nucleus Accumbens, Receptors, Dopamine, Stereotaxic Techniques, Dopamine Agents, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, Dopamine D1, Receptors, Dopamine D2, Quinpirole, Rats
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