D 1 Dopamine Receptor Activation Required for Postsynaptic Expression of D 2 Agonist Effects
Abstract
D 1 and D 2 dopamine receptors exert synergistic effects on the firing rates of basal ganglia neurons and on the expression of stereotyped behavior in rats. Moreover, the ability of D 2 agonists to induce changes in basal ganglia single unit activity and spontaneous motor activity is dependent upon the presence of endogenous dopamine to stimulate D 1 receptors; in rats treated with α-methyl- p -tyrosine to reduce endogenous dopamine levels, the neurophysiological and behavioral effects of the D 2 agonist quinpirole are significantly attenuated, while the effects of nonselective agonists like apomorphine, which stimulate both D 1 and D 2 receptors, or combinations of a D 2 agonist and a D 1 agonist are not attenuated. Thus, the previously held view that D 2 receptors alone are responsible for evoking the changes in behavior and basal ganglia output induced by nonselective dopamine agonists and endogenous dopamine is not supported by these results, which indicate that these phenomena require concurrent stimulation of both dopamine receptor subtypes.
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Under normal conditions, a synergistic balance of D1R- and D2R-like activation exists in striatal regions.
“Under normal conditions, a synergistic balance of D1R- and D2R-like activation exists in striatal regions (Walters et al 1987; LaHoste et al 1993; Gerfen et al 1995; Wise et al 1996; Hu and White 1997).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Walters et al 1987
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- Authors
- Walters, J. R., Bergstrom, D. A., Carlson, J. H., Chase, T. N., & Braun, A. R.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Walters, Judith R.
- Venue
- Science
- Published
- 1987-05-08
- Volume
- 236
- Issue
- 4802
- Pages
- 719-722
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057788173
- Cited by
- 465
- References
- 39
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2018: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, receptor synergy, basal ganglia, quinpirole, apomorphine, alpha-methyl-p-tyrosine, endogenous dopamine, stereotypy, spontaneous motor activity, single-unit activity, dopamine agonists
- MeSH terms
- Animals, Apomorphine, Basal Ganglia, Benzazepines, Dopamine, Ergolines, Methyltyrosines, Neurons, Phenethylamines, Receptors, Dopamine, Stereotyped Behavior, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, Dopamine D1, Receptors, Dopamine D2, Quinpirole, alpha-Methyltyrosine, Rats
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