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Cited by 100Dementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Hypersensitivity to scopolamine in the elderly

Flicker, Charles, Ferris, Steven H., Serby, Michael·1992·Psychopharmacology
DOI 10.1007/bf02245172
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Abstract

Scopolamine hydrobromide, 0.43 mg/70 kg, was administered by subcutaneous injection to ten young and ten elderly subjects. A comprehensive neuropsychological test battery was used to assess the effects of scopolamine, as compared to placebo, on cognitive function. As previously reported for this group of young subjects, scopolamine significantly impaired performance on tests of recent memory and visuospatial praxis. The same effects were observed in the elderly subjects, but the magnitude of the effects was much larger. The scopolamine injections produced significant psychomotor slowing in the elderly, whereas higher doses of the drug are required to produce this effect in young subjects. In both young and old subjects scopolamine failed to affect immediate memory, language function, object sorting, and the frequency of intrusion errors (although trends toward an effect were more apparent in the elderly). Remote memory, tested in the elderly only, was also unaffected. The results suggest that scopolamine's cognitive effects are quantitatively more pronounced in elderly subjects than young subjects, but that they are qualitatively similar and do not constitute a valid model for the cognitive dysfunction associated with Alzheimer's disease.

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Crossref · 10.1007/bf02245172

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  • A well-known risk with anticholinergic medications is acute impairment in specific aspects of cognition (e.g., working memory, attention, psychomotor speed), demonstrated in single dose experimental studies and cohort studies.

    “A well-known risk with anticholinergic medications is acute impairment in specific aspects of cognition (e.g., working memory, attention, psychomotor speed) which has been demonstrated in single dose experimental studies 9-12 and cohort studies.13”

    From Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study (2015) · cites this paper as [11]

Cites

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Research works printed but not linked: 26

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Authors
Flicker, C., Ferris, S. H., & Serby, M.
Affiliations
NYU Langone Health (US)
ORCID
Ferris, Steven H.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1992-06
Volume
107
Issue
2-3
Pages
437-441
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02245172
OpenAlex
W1965868118
Cited by
100
References
1
Citations by year
2026: 2 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
3.06
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH040410, P50MH043486)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
scopolamine, cognitive impairment, older adults, age differences, memory, psychomotor retardation, Alzheimer's disease, neuropsychological assessment
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cognition, Drug Hypersensitivity, Hemodynamics, Humans, Memory, Memory, Short-Term, Mental Processes, Middle Aged, Parasympatholytics, Psychomotor Performance, Scopolamine, Space Perception

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