The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effects of trazodone on EEG sleep and clinical state in major depression
Abstract
The effects of the antidepressant trazodone on clinical state and on EEG sleep in eight outpatients with a major depressive disorder were investigated in a single blind study. A medication period of 5 weeks was preceded and followed by one week placebo treatment. Five subjects showed a positive treatment response. Trazodone did not influence sleep continuity and slow wave sleep, but did suppress REM sleep significantly. A significant increase of REM sleep latency was also found. These results are in contrast with earlier reports on trazodone's effects on EEG sleep but are in accordance with the general finding that antidepressants influence REM sleep characteristics without necessarily affecting sleep continuity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency.
“The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency [Mouret et al., 1988;Ware et al., 1994;van Bemmel and Havermans, 1992;Scharf and Sachais, 1990].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as van Bemmel and Havermans, 1992
Trazodone did not influence sleep continuity or slow wave sleep, but significantly suppressed REM sleep and increased REM latency in depressed patients.
“Trazodone did not influence sleep continuity or slow wave sleep, but significantly suppressed REM sleep and increased REM latency in depressed patients [van Bemmel and Havermans, 1992].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as van Bemmel and Havermans, 1992
Citations
Cites
MANOVA method for analyzing repeated measures designs: An extensive primer.
O'Brien, R. G., & Kaiser, M. K. (1985) · Psychological Bulletin · doi:10.1037/0033-2909.97.2.316 · Cited by 1,148
Sleep deprivation: effect on sleep stages and EEG power density in man
Borbély, A. A., Baumann, F., Brandeis, D., Strauch, I., & Lehmann, D. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90225-x · Cited by 1,013
Flagged first, then by citations
Research works printed but not linked: 17
- Beersma DGM, Dijk DJ, Blok CGH, Everhardus I (1990) REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity. Electroencephalogr Clin Neurophysiol 76:114–122 · DOI
- Borbély AA (1987) The S-Deficiency hypothesis of depression and the two-process model of sleep regulation. Pharmacopsychiatry 20:23–29 · DOI
- Coble PA, Kupfer DJ, Shaw DH (1981) Distribution of REM latency in depression. Biol Psychiatry 16:453–466
- Dijk DJ, Strijkstra A, Daan S, Beersma DGM, van den Hoofdakker RH (1991) Effect of clomipramine on sleep and EEG power spectra in the diurnal rodentEutamias Sibiricus. Psychopharmacology 103:375–379 · DOI
- Elsenga S (1988) Een zelfbeoordelingsschaal voor depressie. T voor Psychiatrie 30:114–126
- Gillin JC, Borbély AA (1985) Sleep, a neurobiological window on affective disorders. TINS 8:573–542
- Gillin JC, Kripke DF, Risch SC, Schuckit M (1989) Slow wave sleep: relationship to primary alcoholism and to sleep deprivation in depression. In: Wauquier A, Dubovic C, Radulovacki M (eds) Slow wave sleep. Raven Press, New York, pp 141–153
- Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychiatry 16:278–296 · DOI
- Montgomery J, Oswald I, Morgan K (1983) Trazodone enhances sleep in subjective quality but not objective duration. J Clin Pharmacol 16:139–144 · DOI · Paper page
- Mouret J, Lemoine P, Minuit MP, Benkelfat C, Renardet M (1988) Effects of trazodone on the sleep of depressed subjects, a polygraphic study. Psychopharmacology 95:S37-S43 · DOI · Paper page
- Mulder-Hajonides van der Meulen WREH (1981) Measurement of subjective sleep quality. In: Proceedings of the European Sleep Congress, Amsterdam, The Netherlands
- Nicholson AN, Bradley CM, Pascoe PE (1989) Medications: effect on sleep and wakefulness. In: Kryger M, Roth T, Dement W (eds) Principles and practice of sleep medicine. WB Saunders, Philadelphia, pp 228–236
- Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service Institute, Los Angeles
- Vogel GW (1983) Evidence for REM sleep deprivation as the mechanism of action of antidepressant drugs. Prog Neuropharmacol Biol Psychiatry 7:343–349 · DOI
- Vogel GW, Buffenstein A, Minter K, Hennessey A (1990) Drug effects on REM sleep and on endogenous depression. Neurosci Biobehav Rev 14:49–63 · DOI
- Ware JC, Pittard JT (1990) Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults. J Clin Psychiatry 519 [suppl]:18–22
- Zerssen D von (1976) Die Befindlichkeitsskala. Manual Beltz, Weinheim
Cited by
Sorted by citations
Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Parasomnias and Antidepressant Therapy: A Review of the Literature
Kierlin, L., & Littner, M. R. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00071 · Cited by 55
Avoiding and Managing Anticholinergic Effects of Antidepressants
Riedel, W. J., & van Praag, H. M. (1995) · CNS Drugs · doi:10.2165/00023210-199503040-00002 · Cited by 34
Metadata
- Authors
- van Bemmel, A. L., Havermans, R. G., & van Diest, R.
- Venue
- Psychopharmacology
- Published
- 1992-06
- Volume
- 107
- Issue
- 4
- Pages
- 569-574
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2086077100
- Cited by
- 67
- References
- 2
- Citations by year
- 2026: 4 · 2025: 3 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- trazodone, major depressive disorder, antidepressant effects, REM sleep suppression, REM latency, slow-wave sleep, sleep continuity, sleep EEG, treatment response
- MeSH terms
- Adult, Depressive Disorder, Electroencephalography, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Stages, Sleep, REM, Trazodone, Single-Blind Method
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
