Acetyl-levo-carnitine protects against MPTP-induced parkinsonism in primates
Abstract
Acetyl-levo-carnitine (ALC) protects against 1-methyl, 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity in the nonhuman primate. ALC pretreated monkeys do not show signs of parkinsonism or electroretinographic changes typical of dopaminergic deficiency when given MPTP. In addition, pilot neurochemical and morphological data confirm a partial protection effect. While MAO-B inhibitors, like L-Deprenyl, are thought to protect dopaminergic neurons from MPTP-induced cell death by preventing the conversion of MPTP to its toxic metabolite MPP+, ALC is not known to have MAO-B affinity. Converging evidence suggests that ALC may affect directly mitochondrial respiration, which is known to be the target of MPP+ and affected in human neurodegenerative diseases, including Parkinson's disease. The results of this study point to new therapeutic avenues for the treatment of these nosologic entities.
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Carnitine and β-hydroxybutyrate has shown to protect against MPTP toxicity.
“Carnitine and β-hydroxybutyrate has shown to protect against MPTP toxicity189-191.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [189]
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Mitochondrial Approaches for Neuroprotection
Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works
- Authors
- Bodis-Wollner, I., Chung, E., Ghilardi, M. F., Glover, A., Onofrj, M., Pasik, P., & Samson, Y.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section
- Published
- 1991-03
- Volume
- 3
- Issue
- 1
- Pages
- 63-72
- ISSN
- 0936-3076 (ISSN-L)
- OpenAlex
- W2056548160
- Cited by
- 51
- References
- 34
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neural Transmission - Parkinsons Disease and Dementia Section (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns022953-03, 5p50ns011631-15, 5r01ey001708-13)
- National Eye Institute (EY-01708)
- National Institute of Neurological Disorders and Stroke (NS11631, NS-22953)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- MPTP, parkinsonism, Parkinson's disease, neuroprotection, dopaminergic neurons, mitochondrial respiration, MPP+, monoamine oxidase B inhibitors, selegiline, non-human primates, monkeys, neurodegeneration
- MeSH terms
- Acetylcarnitine, Animals, Carbidopa, Caudate Nucleus, Electroretinography, Female, Homovanillic Acid, Immunohistochemistry, Levodopa, Macaca fascicularis, Male, Parkinson Disease, Secondary, Substantia Nigra, MPTP Poisoning
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