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Cited by 296Visual perception and processing mechanismsParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients

Bodis-Wollner, I.·1990·Trends in Neurosciences
DOI 10.1016/0166-2236(90)90113-o
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Abstract

In patients affected by Parkinson's disease, and in the monkey model of this disease, visual defects have been shown using psychophysical and electrophysiological measures of spatial and temporal contrast sensitivity. These studies imply an essential role for dopamine in primate vision. There is electrophysiological and neurochemical evidence to suggest that at least part of the problem is impaired retinal processing caused by systemic dopaminergic deficiency. Some of the deficits that have been demonstrated, consistent with physiological studies, suggest that center-surround interaction of neurons may suffer as a consequence of dopaminergic deficiency. The role of the regulation of retinal dopamine (D1 and D2) receptors in primate vision and of the balance of these receptors in presynaptic dopaminergic deficiency is not yet determined. Using sinusoidal grating stimuli in cognitively loaded tasks may increase understanding of the behavioral consequences of visual deficits seen in dopamine deficiency syndromes.

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Crossref · 10.1016/0166-2236(90)90113-o

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  • Abnormalities in visual function are reported in PD patients and correlated with changes in retinal tissue.

    “Moreover, abnormalities in visual function have been reported (Bodis-Wollner, 1990; Nowacka et al., 2014) in PD patients and correlated with changes in retinal tissue (La Morgia et al., 2013; Yu et al., 2014) (Table 1).”

    From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Bodis-Wollner, 1990

  • Dopamine deficiency has been linked to impaired perceptual and electrophysiological response to contrast signals including those presented in a center surround paradigm.

    “For example, dopamine deficiency has been linked to impaired perceptual and electrophysiological response to contrast signals including those presented in a center surround paradigm (41,42).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [41]

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Authors
Bodis-Wollner, I.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Bodis-Wollner, I.
ORCID
Bodis-Wollner, I.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1990-07
Volume
13
Issue
7
Pages
296-302
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/0166-2236(90)90113-o
OpenAlex
W1969334748
Cited by
296
References
58
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 13 · 2019: 5 · 2018: 7 · 2017: 11 · 2016: 4 · 2015: 12 · 2014: 5 · 2013: 7 · 2012: 13
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p50ns011631-15, 5r01ey001708-13)
  • National Eye Institute (EY-01708)
  • National Institute of Neurological Disorders and Stroke (NS11631)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
Parkinson's disease, dopamine deficiency, visual deficits, contrast sensitivity, retinal processing, center-surround interactions, dopamine D1 receptor, dopamine D2 receptor, primate vision, cognitive load
MeSH terms
Animals, Haplorhini, Dopamine, Humans, Parkinson Disease, Vision Disorders, Vision Tests, Contrast Sensitivity

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