Effects ofl-carnitine loading on the aerobic and anaerobic performance of endurance athletes
Abstract
L-Carnitine (L-C), a well known physiological carrier across the inner mitochondrial membrane of activated long chain fatty acids and acceptor of acyl groups from acyl-CoA, has been recently synthesised industrially. This has made it possible to study the effects of L-C loading (4 g X d(-1) by mouth over a period of 2 weeks) on the aerobic and anaerobic performance of 6 long distance competitive walkers. As a result of the treatment: 1) mean total, free and esterified serum L-C both at rest and shortly after completing a 120 min walk at about 65% of the individual maximal aerobic power (VO2max) were significantly increased; 2) VO2max increased 6%, from 54.5 +/- 3.7 (S.D.) to 57.8 +/- 4.7 m1O2 X kg(-1) X min(-1) (P less than 0.02); 3) blood lactate concentration (Lab) as a consequence of short bouts repeated exercise (series of 10, 15 and 20 jumps off both feet on a force platform) was unchanged; 4) heart rate, pulmonary ventilation, oxygen consumption, and respiratory quotient in the same conditions as for 1) were unchanged. It is concluded that, in trained athletes, as a consequence of L-C loading VO2max is slightly but significantly raised, probably as a result of an activation of substrate flow through the TCA cycle, whereas the lipid contribution to metabolism in prolonged submaximal exercise remains unchanged.
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Research investigating the impact of carnitine supplementation on muscle fuel metabolism and/or exercise performance has produced inconclusive results.
“To date, research investigating the impact of carnitine supplementation on muscle fuel metabolism and/or exercise performance has produced inconclusive results [[185], [186], [187], [188], [189], [190], [191]].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [186]
Cites
Biochemical Adaptations to Endurance Exercise in Muscle
Holloszy, J. O., & Booth, F. W. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.001421 · Cited by 1,053 · see citing works
Newsholme, E. A., & Start, C. (1973) · Wiley eBooks · Cited by 768 · see citing works
Carnitine Deficiency of Human Skeletal Muscle with Associated Lipid Storage Myopathy: A New Syndrome
Engel, A. G., & Angelini, C. I. (1973) · Science · doi:10.1126/science.179.4076.899 · Cited by 513 · see citing works
Adaptation of muscle to exercise
Molé, P. A., Oscai, L. B., & Holloszy, J. O. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106730 · Cited by 320 · see citing works
Enzymological determination of free carnitine concentrations in rat tissues
Marquis, N. R., & Fritz, I. B. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40236-6 · Cited by 317 · see citing works
Effects of specific muscle training on VO2 on-response and early blood lactate
Cerretelli, P., Pendergast, D. R., Paganelli, W. C., & Rennie, D. W. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.47.4.761 · Cited by 205 · see citing works
Self-citationG., S. P. (1973) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-59-143 · Cited by 178 · see citing works
The Effects of‘ Muscle ExtractrJ on the Oxidation of Pnlmitic Acid by Liver Slices and Homogenates1
Fritz, I. B. (1955) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1955.tb01256.x · Cited by 171 · see citing works
Nutrition for Endurance Sport: Carbohydrate and Fluid Balance*
COSTILL, D. L., & Miller, J. (1980) · International Journal of Sports Medicine · doi:10.1055/s-2008-1034623 · Cited by 165 · see citing works
Disorders of lipid metabolism in muscle
Mauro, S. D., Trevisan, C. L., & Hays, A. (1980) · Muscle & Nerve · doi:10.1002/mus.880030502 · Cited by 130 · see citing works
Guarnieri, G., Ranieri, F., Toigo, G., et al. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.7.1489 · Cited by 96 · see citing works
Effects of acute moderate-intensity exercise on carnitine metabolism in men and women
Lennon, D. L. F., Stratman, F. W., Shrago, E., NAGLE, F. J., Madden, M. A., Hanson, P., & Carter, A. L. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.489 · Cited by 86 · see citing works
Hülsmann, W. C., SILIPRANDI, D., Ciman, M., et al. (1964) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(64)90271-5 · Cited by 72 · see citing works
Effect of carnitine on branched-chain amino acid oxidation by liver and skeletal muscle.
Paul, H. S., & Adibi, S. A. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.234.5.e494 · Cited by 63 · see citing works
The effect of acylcarnitines on the oxidation of branched chain α-keto acids in mitochondria
Bremer, J., & Davis, E. J. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90016-4 · Cited by 41 · see citing works
Automated method for L-carnitine determination.
Seccombe, D. W., Dodek, P., Frohlich, J., et al. (1976) · Clinical Chemistry · doi:10.1093/clinchem/22.10.1589 · Cited by 33 · see citing works
Carnitine metabolism in human subjects III. Metabolism in disease
Mitchell, M. E. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.4.645 · Cited by 30 · see citing works
van Hinsbergh, V. W. M., Veerkamp, J. H., & Cordewener, J. H. G. (1980) · International Journal of Biochemistry · doi:10.1016/0020-711x(80)90007-5 · Cited by 23 · see citing works
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Evidence-based supplements for the enhancement of athletic performance
Peeling, P., Binnie, M. J., Goods, P. S. R., Sim, M., & Burke, L. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0343 · Cited by 225 · see citing works
Barnett, C., Costill, D. L., Vukovich, M. D., Cole, K. J., Goodpaster, B. H., Trappe, S. W., & Fink, W. J. (1994) · International Journal of Sport Nutrition · doi:10.1123/ijsn.4.3.280 · Cited by 107 · see citing works
Wächter, S., Vogt, M., Kreis, R., Boesch, C., Bigler, P., Hoppeler, H., & Krähenbühl, S. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00804-x · Cited by 77 · see citing works
Colombani, P., Wenk, C., Kunz, I., Kr�henb�hl, S., Kuhnt, M., Arnold, M., Frey-Rindova, P., Frey, W., & Langhans, W. (1996) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00334420 · Cited by 72 · see citing works
Nutritional Considerations for the Vegan Athlete
West, S., Monteyne, A. J., van der Heijden, I., Stephens, F. B., & Wall, B. T. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.012 · Cited by 42 · see citing works
Broad, E. M., Maughan, R. J., & Galloway, S. D. R. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.6.567 · Cited by 35 · see citing works
Effect of Glycine Propionyl-L-Carnitine on Aerobic and Anaerobic Exercise Performance
Smith, W. A., Fry, A. C., Tschume, L. C., & Bloomer, R. J. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.1.19 · Cited by 30 · see citing works
- Authors
- Marconi, C., Sassi, G., Carpinelli, A., & Cerretelli, P.
- Affiliations
- University of Milan (IT)
- Venue
- European Journal of Applied Physiology and Occupational Physiology
- Published
- 1985-08
- Volume
- 54
- Issue
- 2
- Pages
- 131-135
- ISSN
- 0020-9376 (ISSN-L)
- 0301-5548
- 1439-6327
- OpenAlex
- W2036907814
- Cited by
- 102
- References
- 18
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 3 · 2016: 1 · 2014: 1 · 2013: 3
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- carnitine supplementation, endurance athletes, aerobic performance, anaerobic performance, VO2max, fat oxidation, fatty acid oxidation, carbohydrate oxidation, energy metabolism, dietary supplementation, long-distance running, anaerobic capacity, muscle lactate, muscle creatine kinase
- MeSH terms
- Adolescent, Adult, Aerobiosis, Anaerobiosis, Blood Gas Analysis, Carnitine, Humans, Middle Aged, Physical Endurance, Pulmonary Gas Exchange
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