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Cited by 19Neutrophil, Myeloperoxidase and Oxidative MechanismsExercise and Physiological ResponsesSleep and Work-Related Fatigue

Granulocyte chemiluminescence response to serum opsonized zymosan particlesex vivo during long-term strenuous exercise, energy and sleep deprivation in humans

Wiik, P., Opstad, P. K., Bøyum, A.·1996·European Journal of Applied Physiology and Occupational Physiology
DOI 10.1007/bf02425484
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Abstract

The chemiluminescence response of granulocytes to serum opsonized zymosan particles (SOZ) ex vivo was investigated during two ranger training courses lasting 7 days with continuous moderate physical activities corresponding to about 32% of maximal oxygen uptake or 35000 kJ.24 h-1, with energy deficiency (energy supply 0-4000 kJ.24 h-1), and less than 3-h sleep during the 7 days. Significant granulocytosis in combination with a lymphopenia in peripheral blood was observed during the whole course. A priming of the granulocytes for accentuated chemiluminescence response to SOZ was observed during the first days of the course with a maximal increase on day 3 in course A (+35% of control response) and on day 1 in course B (+12%). Thereafter, reduced responses to SOZ compared to control values (-28% and -21% in course A and B) were observed. In course A, a group (n = 8) receiving 5000 kJ.24 h-1 of additional energy, showed a more pronounced priming (maximum +57% versus +21% of control response) during the first days. In course B, all the cadets had 3 h of organised rest/sleep on day 5, and a second priming of the chemiluminescence response was observed on the subsequent 2 days. These data indicated that moderate, continuous, predominantly aerobic physical activities for 1-3 days around the clock primed the production of reactive oxygen species in granulocytes. This priming may be beneficial for, for example, host defence against micro-organisms, but may also contribute to inflammatory damage to normal tissues such as muscle, tendons and joints during exercise. However, when the moderate exercise continued for several more days, a down-modulation of the granulocyte response was observed. The findings of this study further support the possibility that moderate physical activity stimulates immunity, while more extreme duration of the same activities may result in a down-modulation of non-specific (and specific) immunity.

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  • SWS, by inducing a unique endocrine constellation, supports the interaction between APCs and T cells, which results in a stronger immunological memory.

    “Thus the general idea is that SWS, by inducing this unique endocrine constellation, supports the interaction between APCs and T cells, which results in a stronger immunological memory (578).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [578]

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Authors
Wiik, P., Opstad, P. K., & Bøyum, A.
Affiliations
Norwegian Defence Research Establishment (NO)
Venue
European Journal of Applied Physiology and Occupational Physiology
Publisher
Springer Science and Business Media LLC
Published
1996-05
Volume
73
Issue
3-4
Pages
251-258
ISSN
  • 0020-9376 (ISSN-L)
  • 0301-5548
  • 1439-6327
DOI
10.1007/bf02425484
OpenAlex
W2021662384
Cited by
19
References
38
Citations by year
2025: 1 · 2021: 1 · 2019: 1 · 2015: 2 · 2013: 1
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
exercise immunology, energy deprivation, sleep deprivation, granulocytosis, lymphopenia, reactive oxygen species, exercise-induced inflammation, endurance training
MeSH terms
Blood, Energy Intake, Food, Food Deprivation, Granulocytes, Humans, Hydrocortisone, Kinetics, Leukocyte Count, Luminescent Measurements, Opsonin Proteins, Sleep Deprivation, Zymosan, Exercise

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