The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Sensitive fluorometric method for tissue tocopherol analysis
Abstract
A sensitive, highly reproducible method for tissue tocopherol analysis that combines saponification in the presence of large amounts of ascorbic acid to remove interfering substances, extraction of the nonsaponifiable lipids with hexane, and fluorometric measurement of the tocopherol is presented. The nonsaponifiable lipid phase contained only one fluorochrome in the 290 nm excitation and 330 nm emission range, and it was identified as tocopherol by thin layer and column chromatography. Column chromatography of the hexane extract of a saponified,14 C‐tocopherolspiked microsomal fraction showed that no measurable oxidation to tocopherylquinone has occurred. The fluorometric method for tocopherol analysis was applied to homogenates and subcellular fractions from rat liver, kidney, lung, and heart and red blood cells. The heavy mitochondrial and microsomal fractions had the highest subcellular concentrations of tocopherol.
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Cites
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
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Thin-layer chromatography, a laboratory handbook
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James, A. T. (1968) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)99159-9 · Cited by 538
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Crane, F. L., Widmer, C., Lester, R. L., Hatefi, Y., & Fechner, W. (1959) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(59)90024-1 · Cited by 220
Simultaneous fluorometric determinations of vitamins A and E in human serum and plasma
Thompson, J. N., Erdödy, P., & Maxwell, W. B. (1973) · Biochemical Medicine · doi:10.1016/0006-2944(73)90045-8 · Cited by 108
The metabolism of C14‐α‐tocopheryl quinone and C14‐α‐tocopheryl hydroquinone
Chow, C. K., Draper, H. H., Csallany, A. S., & Chiu, M. (1967) · Lipids · doi:10.1007/bf02531852 · Cited by 26
Cited by
[16] Vitamin E analysis methods for animal tissues
Desai, I. D. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05019-9 · Cited by 850
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
Sontag, T. J., & Parker, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201466200 · Cited by 458
Lipid Peroxidation and Mechanisms of Toxicity
Horton, A. A., Fairhurst, S., & Bus, J. S. (1987) · CRC Critical Reviews in Toxicology · doi:10.3109/10408448709089856 · Cited by 339
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Tocopherols and tocotrienols in membranes: A critical review
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Metadata
- Authors
- Taylor, S. L., Lamden, M. P., & Tappel, A. L.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1976-07
- Volume
- 11
- Issue
- 7
- Pages
- 530-538
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W1983021928
- Cited by
- 356
- References
- 7
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taylor, S. L., Lamden, M. P., & Tappel, A. L. (1976). Sensitive fluorometric method for tissue tocopherol analysis. Lipids. https://doi.org/10.1007/bf02532898
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
