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Measurement of lipid peroxidation in vivo: A comparison of different procedures
Abstract
A study was undertaken to investigate whether some of the methods commonly used to detect lipid peroxidation of cellular membranes in vivo correlate with each other. The study was performed with the livers of bromobenzene‐intoxicated mice, in which lipid peroxidation develops when the depletion of glutathione (GSH) reaches a threshold value. The methods tested and compared were the following: i) measurement of the malondialdehyde (MDA) content of the liver; ii) detection of diene conjugation absorption in liver phospholipids; iii) measurement of the loss of polyunsaturated fatty acids in liver phospholipids; and iv) determination of carbonyl functions formed in acyl residues of membrane phospholipids as a result of the peroxidative breakdown of phospholipid fatty acids. Correlations among the values obtained with these methods showed high statistical significances, indicating that the procedures measure lipid peroxidation in vivo with comparable reliability. Analogously, the four methods appeared also to correlate when applied to in vitro microsomal lipid peroxidation.
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Cited by
Drummen, G. P. C., van Liebergen, L. C. M., Op den Kamp, J. A. F., & Post, J. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00848-1 · Cited by 594
Ratio‐fluorescence microscopy of lipid oxidation in living cells using C11‐BODIPY581/591
Pap, E. H. W., Drummen, G. P. C., Winter, V. J., Kooij, T. W. A., Rijken, P., Wirtz, K. W. A., Op den Kamp, J. A. F., Hage, W. J., & Post, J. A. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00696-1 · Cited by 329
Comet assay and analysis of micronucleus formation in patients with rheumatoid arthritis.
Karaman, A., Binici, D. N., & Melikoğlu, M. A. (2011) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.11.014 · Cited by 39
Metadata
- Authors
- Pompella, A., Maellaro, E., Casini, A. F., Ferrali, M., Ciccoli, L., & Comporti, M.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1987-03
- Volume
- 22
- Issue
- 3
- Pages
- 206-211
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W1965290364
- Cited by
- 160
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Measurement of lipid peroxidation in vivo: A comparison of different procedures. https://app.cochat.ai/papers/10.1007/bf02537304
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- Pompella, A., Maellaro, E., Casini, A. F., Ferrali, M., Ciccoli, L., & Comporti, M. (1987). Measurement of lipid peroxidation in vivo: A comparison of different procedures. Lipids. https://doi.org/10.1007/bf02537304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
