Cited by 68Fatty Acid Research and HealthDermatology and Skin DiseasesEicosanoids and Hypertension Pharmacology

The significance of polyunsaturated fatty acids in cutaneous biology

Ziboh, Vincent A.·1996·Lipids

Abstract

The skin epidermis displays a highly active metabolism of polyunsaturated fatty acids (PUFA). Dietary deficiency of linoleic acid (LA) and 18-carbon (n-6) PUFA results in characteristic scaly skin disorder and excessive epidermal water loss. Arachidonic acid, a 20-carbon (n-6) PUFA is metabolized via the cyclooxygenase pathway into predominantly prostaglandin E2 (PGE2) PGF2 alpha, and PGD2 and via the lipoxygenase pathway into predominantly 15-hydroxyeicosatetraenoic acid (15-HETE). The prostaglandins modulate normal skin physiological processes at low concentrations and inflammatory reactions at high concentrations. Similarly, the very active epidermal 15-lipoxygenase transforms dihomogammalinolenic acid (DGLA) into 15-hydroxy eicosatrienoic acid (15-HETrE), eicosapentaenoic acid (EPA) into 15-hydroxyeicosapentaenoic acid (15-HEPE) and docosahexaenoic acid (DHA) into 17-hydroxydocosahexaenoic acid (17-HDoHE), respectively. These monohydroxy acids exhibit anti-inflammatory properties. In contrast, the 18-carbon (n-6) PUFA is transformed into 13-hydroxy-9,11-octadecadienoic acid (13-HODE), which exerts antiproliferative properties in the tissue. Thus, the supplementation of diets with appropriate purified vegetable oils and/or fish oil may generate local cutaneous anti-inflammatory metabolites which could serve as a less toxic in vivo monotherapy or as adjuncts to standard therapeutic regimens for the management of skin inflammatory disorders.

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Crossref · 10.1007/bf02637085

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  • Omega-3 acids obtained from fish oil-eicosapentaenoic acid and docosahexaenoic acid-play an important role in skin function.

    “Omega-3 acids obtained from fish oil—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—also play an important role in skin function.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [185]

  • Supplementation of diets with vegetable or fish oils may generate local cutaneous anti-inflammatory metabolites, which could serve as adjuncts in the management of skin inflammatory disorders.

    “Furthermore, the supplementation of diets with vegetable or fish oils may generate local cutaneous anti-inflammatory metabolites, which could serve as adjuncts in the management of skin inflammatory disorders [185].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [185]

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Authors
Ziboh, V. A.
Affiliations
University of California, Davis (US)
Corresponding author
Ziboh, Vincent A.
Venue
Lipids
Publisher
Wiley
Published
1996-01
Volume
31
Issue
1Part2
Pages
S249-53
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
OpenAlex
W2054234087
Cited by
67
References
30
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
polyunsaturated fatty acids, epidermis, linoleic acid deficiency, arachidonic acid metabolism, cyclooxygenase pathway, lipoxygenase pathway, prostaglandins, 15-hydroxyeicosatetraenoic acid, dihomo-gamma-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, 13-hydroxyoctadecadienoic acid, anti-inflammatory metabolites, skin inflammation, dietary supplementation, fish oil, vegetable oils
MeSH terms
Animals, Cell Division, Dietary Fats, Unsaturated, Epidermis, Fatty Acids, Unsaturated, Humans, Linoleic Acids, Lipoxygenase, Oxygen, Linoleic Acid

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