The significance of polyunsaturated fatty acids in cutaneous biology
Abstract
The skin epidermis displays a highly active metabolism of polyunsaturated fatty acids (PUFA). Dietary deficiency of linoleic acid (LA) and 18-carbon (n-6) PUFA results in characteristic scaly skin disorder and excessive epidermal water loss. Arachidonic acid, a 20-carbon (n-6) PUFA is metabolized via the cyclooxygenase pathway into predominantly prostaglandin E2 (PGE2) PGF2 alpha, and PGD2 and via the lipoxygenase pathway into predominantly 15-hydroxyeicosatetraenoic acid (15-HETE). The prostaglandins modulate normal skin physiological processes at low concentrations and inflammatory reactions at high concentrations. Similarly, the very active epidermal 15-lipoxygenase transforms dihomogammalinolenic acid (DGLA) into 15-hydroxy eicosatrienoic acid (15-HETrE), eicosapentaenoic acid (EPA) into 15-hydroxyeicosapentaenoic acid (15-HEPE) and docosahexaenoic acid (DHA) into 17-hydroxydocosahexaenoic acid (17-HDoHE), respectively. These monohydroxy acids exhibit anti-inflammatory properties. In contrast, the 18-carbon (n-6) PUFA is transformed into 13-hydroxy-9,11-octadecadienoic acid (13-HODE), which exerts antiproliferative properties in the tissue. Thus, the supplementation of diets with appropriate purified vegetable oils and/or fish oil may generate local cutaneous anti-inflammatory metabolites which could serve as a less toxic in vivo monotherapy or as adjuncts to standard therapeutic regimens for the management of skin inflammatory disorders.
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Omega-3 acids obtained from fish oil-eicosapentaenoic acid and docosahexaenoic acid-play an important role in skin function.
“Omega-3 acids obtained from fish oil—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—also play an important role in skin function.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [185]
Supplementation of diets with vegetable or fish oils may generate local cutaneous anti-inflammatory metabolites, which could serve as adjuncts in the management of skin inflammatory disorders.
“Furthermore, the supplementation of diets with vegetable or fish oils may generate local cutaneous anti-inflammatory metabolites, which could serve as adjuncts in the management of skin inflammatory disorders [185].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [185]
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- Authors
- Ziboh, V. A.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Ziboh, Vincent A.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 31
- Issue
- 1Part2
- Pages
- S249-53
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2054234087
- Cited by
- 67
- References
- 30
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- polyunsaturated fatty acids, epidermis, linoleic acid deficiency, arachidonic acid metabolism, cyclooxygenase pathway, lipoxygenase pathway, prostaglandins, 15-hydroxyeicosatetraenoic acid, dihomo-gamma-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, 13-hydroxyoctadecadienoic acid, anti-inflammatory metabolites, skin inflammation, dietary supplementation, fish oil, vegetable oils
- MeSH terms
- Animals, Cell Division, Dietary Fats, Unsaturated, Epidermis, Fatty Acids, Unsaturated, Humans, Linoleic Acids, Lipoxygenase, Oxygen, Linoleic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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