Dyspnea: A sensory experience

Schwartzstein, Richard M.; Manning, Harold L.; Weiss, J. Woodrow; Weinberger, Steven E.

doi:10.1007/bf02719692

Cited by 81Respiratory and Cough-Related ResearchCardiovascular and exercise physiologyChronic Obstructive Pulmonary Disease (COPD) Research

Dyspnea: A sensory experience

Schwartzstein, Richard M., Manning, Harold L., Weiss, J. Woodrow, Weinberger, Steven E.·1990·Lung

DOI 10.1007/bf02719692

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Abstract

Dyspnea--an unpleasant or uncomfortable awareness of breathing or need to breathe--is a common symptom of patients with cardiopulmonary disease. Although often thought of as a single symptom, dyspnea probably subsumes many sensations. Experimental conditions used to induce dyspnea are characterized by discrete groups or clusters of descriptive phrases. Similarly, as the language of dyspnea is refined further, different disease states may be distinguishable by the nuances of breathlessness described by patients. Evidence is gathering that the sensations of dyspnea are modified by information from a variety of receptors throughout the respiratory system. The sense of effort, although still important in the breathlessness associated with mechanical loads, is insufficient to explain the dyspnea arising from a number of experimental and clinical conditions. As our understanding of the interactions between effort and afferent information from the respiratory system grows, new therapeutic interventions to alleviate dyspnea are likely to follow.

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Breathlessness perception is driven by a mismatch between demand for ventilation and afferent information on actual ventilation.
“Breathlessness perception is believed to be driven by a mismatch between the two.”
From The Breathing, Thinking, Functioning clinical model: a proposal to facilitate evidence-based breathlessness management in chronic respiratory disease (2017) · cites this paper as [14]

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Authors: Schwartzstein, R. M., Manning, H. L., Weiss, J. W., & Weinberger, S. E.
Affiliations: Harvard University (US)
ORCID: Schwartzstein, Richard M.
Weiss, J. Woodrow
Venue: Lung
Publisher: Springer Science and Business Media LLC
Published: 1990-12
Volume: 168
Issue: 1
Pages: 185-199
ISSN: 0341-2040 (ISSN-L)
1432-1750
DOI: 10.1007/bf02719692
OpenAlex: W1982542411
Cited by: 80
References: 89
Citations by year: 2026: 4 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Lung (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl019170-20)
National Heart, Lung, and Blood Institute (HL 19170)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: dyspnea, respiratory sensation, cardiopulmonary disease, respiratory effort, mechanical ventilation
MeSH terms: Dyspnea, Humans, Lung, Mechanoreceptors, Respiration, Thorax

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Dyspnea: A sensory experience

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