The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Epithelial cell kinetics in the descending colon of the rat
Abstract
Epithelial cell kinetics were investigated in the descending colon of the rat. The number of cells per crypt was found to be approximately 625, with 33 cells per cell column and 19 cell columns per crypt circumference. The growth fraction of the colonic crypt was 0.42, and proliferating cells were situated largely in the lower half of the crypt. The cell cycle time was 50.5 h, with values for the G1, S and G2 phases of 40.0, 7.6 and 2.9 h respectively. Cell migration studies showed that it took 60-72 h for a cell to migrate from the upper border of the proliferative cell compartment in the crypt to the luminal surface of the colon. Data were also obtained from continuous labelling with tritiated thymidine and from studying the circadian rhythm of proliferative activity, which suggest that the cells in the bottom of the crypt may constitute a separate, more slowly cycling (stem)cell compartment.
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“existing estimates from mouse, rat and human indicate that the total number of stem cell divisions per crypt in a lifetime varies greatly across species—for example, there are around 6- to 31-fold more divisions per intestinal stem cell in a human than in a rat over their respective lifetimes”
From Somatic mutation rates scale with lifespan across mammals (2022) · cites this paper as [71]
In the citing paper
“By the end of lifespan, an intestinal stem cell is predicted to have divided around 1,351 times in a mouse, around 486 times in a rat and 2,774–15,257 times in a human (depending on the estimate of cell division rate used).”
From Somatic mutation rates scale with lifespan across mammals (2022) · cites this paper as [71]
Citations
Cites
Cell population kinetics in the intestinal epithelium of the mouse
Quastler, H., & Sherman, F. G. (1959) · Experimental Cell Research · doi:10.1016/0014-4827(59)90063-1 · Cited by 1,417
Messier, B., & Leblond, C. P. (1960) · American Journal of Anatomy · doi:10.1002/aja.1001060305 · Cited by 810
Extreme sensitivity of some intestinal crypt cells to X and γ irradiation
POTTEN, C. S. (1977) · Nature · doi:10.1038/269518a0 · Cited by 441
Reddy, B. S., & Wynder, E. L. (1973) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/50.6.1437 · Cited by 408
CAIRNIE, A., LAMERTON, L., & STEEL, G. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90055-8 · Cited by 361
Chang, W. W. L., & Leblond, C. P. (1971) · American Journal of Anatomy · doi:10.1002/aja.1001310105 · Cited by 252
Gastrointestinal Epithelial Renewal
Eastwood, G. L. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80221-7 · Cited by 239
Altmann, G. G., & Leblond, C. P. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270104 · Cited by 237
CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE
Potten, C. S., Kovacs, L., & Hamilton, E. (1974) · Cell Proliferation · doi:10.1111/j.1365-2184.1974.tb00907.x · Cited by 212
Cell proliferation studies in the intestinal epithelium of the rat
Cairnie, A. B., & Bentley, R. E. T. (1967) · Experimental Cell Research · doi:10.1016/0014-4827(67)90079-1 · Cited by 201
Research works printed but not linked: 1
- Steel, G.G.: The measurement of the intermitotic period. In: The cell cycle in development and differentiation, Balls, M., Billet, F.S. (eds.), pp. 13–29. Cambridge: University Press 1973
Cited by
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Somatic mutation rates scale with lifespan across mammals
Cagan, A., Baez-Ortega, A., Brzozowska, N., Abascal, F., Coorens, T. H. H., Sanders, M. A., Lawson, A. R. J., Harvey, L. M. R., Bhosle, S., Jones, D., et al. (2022) · Nature · doi:10.1038/s41586-022-04618-z · Cited by 481
Metadata
- Authors
- Rijke, R. P. C., Plaisier, H. M., & Langendoen, N. J.
- Venue
- Virchows Archiv B Cell Pathology
- Published
- 1979-12
- Volume
- 30
- Issue
- 1
- ISSN
- 0340-6075
- Cited by
- 16
- References
- 58
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- CoChat. (2026). Citation check: Epithelial cell kinetics in the descending colon of the rat. https://app.cochat.ai/papers/10.1007/bf02889093
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- Rijke, R. P. C., Plaisier, H. M., & Langendoen, N. J. (1979). Epithelial cell kinetics in the descending colon of the rat. Virchows Archiv B Cell Pathology. https://doi.org/10.1007/bf02889093
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
