The DOI matches its Crossref record.
CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE
Abstract
Data are presented for changes in absolute radioactivity levels and labelling indices (LI) in three tissues: jejunum, colon and dorsal skin in the mouse during conditions of repeated (every 3 hr for 168 hr) 3 H‐TdR (5 μCi) injections. The lengths of S and the cell cycle were estimated. The crypt and mucosal transit times were evaluated. There is a slowly cycling subpopulation in the crypt which may be the goblet cell precursors or a crypt stem cell population. The skin LI data cannot be fitted by a single straight line and the procedure of continuously handling or injecting the animals appears to result in a disturbance of the steady state. The liquid scintillation data for all samples showed some consistent and surprisingly large fluctuations and a clear deviation from linear uptake with increasing time.
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Cited by
Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
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Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742
Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes & Development · doi:10.1101/gad.1674008 · Cited by 629
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
Nalapareddy, K., Nattamai, K. J., Kumar, R. S., Karns, R., Wikenheiser-Brokamp, K. A., Sampson, L. L., Mahe, M. M., Sundaram, N., Yacyshyn, M.-B., Yacyshyn, B., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.056 · Cited by 280
Metadata
- Authors
- Potten, C. S., Kovacs, L., & Hamilton, E.
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 1974-05
- Volume
- 7
- Issue
- 3
- Pages
- 271-283
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- OpenAlex
- W2115777622
- Cited by
- 212
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE. https://app.cochat.ai/papers/10.1111/j.1365-2184.1974.tb00907.x
- The paper
- Potten, C. S., Kovacs, L., & Hamilton, E. (1974). CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE. Cell Proliferation. https://doi.org/10.1111/j.1365-2184.1974.tb00907.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
