An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia
Abstract
Senile cerebral amyloidosis has been investigated using immunoperoxidase and enzyme histochemical techniques in six unfixed brains. Our findings do not support the opinion that vascular and senile plaque amyloid are immunoglobulin-derived. In contrast with recent reports we did not detect prealbumin in senile plaques and congophilic angiopathy lesions. All senile plaques contain complement factors C1q, C3 and C4. The highest peroxidase activity was found in the amyloid nucleus but the corona also showed evident peroxidase activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Strong evidence has implicated the complement system in the pathogenesis of Alzheimer's disease.
“Strong evidence has implicated the complement system in the pathogenesis of Alzheimer’s disease [72–76]”
Cites
Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study
Eikelenboom, P., & Stam, F. C. (1982) · Acta Neuropathologica · doi:10.1007/bf00685397 · Cited by 454 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Activation of the classical complement pathway in brain tissue of Alzheimer patients
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383 · see citing works
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90439-2 · Cited by 127 · see citing works
Eikelenboom, P., Hack, C. E., Kamphorst, W., & Rozemuller, J. M. (1992) · Research in Immunology · doi:10.1016/0923-2494(92)80044-l · Cited by 40 · see citing works
Self-citationBarber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01492-x · Cited by 41 · see citing works
- Authors
- Eikelenboom, P., & Stam, F. C.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- ORCID
- Eikelenboom, P.
- Venue
- Virchows Archiv B Cell Pathology Including Molecular Pathology
- Published
- 1984-12
- Volume
- 47
- Issue
- 1
- Pages
- 17-25
- ISSN
- 0340-6075 (ISSN-L)
- 0042-6431
- OpenAlex
- W2075920000
- Cited by
- 83
- References
- 1
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 1 · 2012: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Virchows Archiv B Cell Pathology Including Molecular Pathology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid plaques, cerebral amyloid, vascular amyloid, cerebral amyloid angiopathy, complement proteins, C1q, complement C3, C4, prealbumin, immunoglobulins
- MeSH terms
- Aged, Alzheimer Disease, Amyloid, Brain, Complement System Proteins, Histocytochemistry, Humans, Immunochemistry, Middle Aged, Prealbumin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
