Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P.L.; Akiyama, H.; Itagaki, S.; McGeer, E.G.

doi:10.1016/0304-3940(89)90843-4

Cited by 383Complement system in diseasesAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P.L., Akiyama, H., Itagaki, S., McGeer, E.G.·1989·Neuroscience Letters

DOI 10.1016/0304-3940(89)90843-4

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Abstract

Positive immunohistochemical staining of Alzheimer brain tissue was obtained with antibodies to proteins associated with classical, but not the alternative, complement pathway. Clq, C3d, C4d are fractions of complement proteins that bind to tissue when the classical complement pathway is activated. Antibodies to these fractions stained senile plaques, dystrophic neurites and some neurofibrillary tangles. C5b-9 is the membrane attack complex which promotes cell lysis when assembled on the plasma membrane. An antibody to a neoantigenic site on this complex stained dystrophic neurites and many neurofibrillary tangles, but not extracellular amyloid. Properdin and fraction Bb of factor B, two proteins that bind to tissue when the alternative complement pathway is activated, were not detected immunohistochemically.

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Authors: McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G.
Affiliations: University of British Columbia (CA)
Corresponding author: McGeer, P.L.
ORCID: McGeer, P.L.
Akiyama, H.
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1989-12
Volume: 107
Issue: 1-3
Pages: 341-346
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(89)90843-4
OpenAlex: W1980565738
Cited by: 383
References: 15
Citations by year: 2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 10
FWCI: 3.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: classical complement pathway, Alzheimer's disease, complement activation, C1q, C3d, C4d, C5b-9 membrane attack complex, amyloid plaques, dystrophic neurites, neurofibrillary tangles, amyloid, alternative complement pathway, properdin, factor B
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Complement Activation, Complement Pathway, Classical, Complement C4, Humans, Immunohistochemistry, Neurofibrils, Peptide Fragments, Complement C1q, Complement C3d, Complement C4b, Complement Membrane Attack Complex

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Activation of the classical complement pathway in brain tissue of Alzheimer patients

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