Association of Microvessel Density with Infiltrating Cells in Human Cutaneous Malignant Melanoma
Abstract
Vascularization and host response to malignant tumors may have common molecular regulators, therefore, we analyzed the relationship between microvessel density (MVD) and tumor infiltrating cells in cutaneous malignant melanoma. Density of lymphocyte subpopulations, macrophages, dendritic cells and CD34(+) microvessels was determined by immunohistochemistry in primary tumor samples from fifty-two patients with melanoma thicker than 1 mm. Intratumoral MVD did not show significant association with infiltration for any of these cell types. In the case of peritumoral reactive cell densities analyzed in the whole patient population, a positive correlation of MVD was found with CD3(+) T cell density. This association was stronger in melanomas >4.0 mm and in visceral metastatic tumors. In these subgroups similar phenomenon was observed for CD8(+) cells. We found significant correlation of MVD with CD68(+) macrophage density only in the highest thickness category, and weak associations with B-cell and dendritic cell infiltration in visceral metastatic cases. MVD did not vary significantly in tumors categorized according to thickness, localization, ulceration or histological type. However, both intratumoral MVD and macrophage infiltration were significantly higher in male patients compared to females. The correlation of immune cell density with tumor vascularization and gender differences in vascularity and macrophage infiltration of melanoma deserve further attention.
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In skin melanoma, increased tumoral vascular density is associated with increased macrophage and T-cell density.
“It was shown in skin melanoma that increased tumoral vascular density is associated with increased macrophage and T-cell density [55].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [55]
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Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma
Balch, C. M., Buzaid, A. C., Soong, S., Atkins, M. B., Cascinelli, N., Coit, D. G., Fleming, I. D., Gershenwald, J. E., Houghton, A. N., Kirkwood, J. M., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.16.3635 · Cited by 2,627 · see citing works
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135 · see citing works
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Zou, W. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1586 · Cited by 2,057 · see citing works
Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., & Carbone, D. P. (1996) · Nature Medicine · doi:10.1038/nm1096-1096 · Cited by 1,977 · see citing works
Ausprunk, D. H., & Folkman, J. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90141-8 · Cited by 1,290 · see citing works
Model Predicting Survival in Stage I Melanoma Based on Tumor Progression
Clark, W. H., Elder, D. E., Guerry, D., Braitman, L. E., Trock, B. J., Schultz, D., Synnestvedt, M. B., & Halpern, A. C. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.24.1893 · Cited by 1,247 · see citing works
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
Leek, R., Lewis, C. E., Whitehouse, R. M., Greenall, M. J., Clarke, J., & Harris, A. L. (1996) · PubMed · Cited by 1,187 · see citing works
Marincola, F. M., Jaffee, E. M., Hicklin, D. J., & Ferrone, S. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60911-6 · Cited by 1,173 · see citing works
Sunderkötter, C. H., Steinbrink, K., Goebeler, M., Bhardwaj, R. S., & Sorg, C. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.3.410 · Cited by 1,113 · see citing works
The origin and function of tumor-associated macrophages
Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., & Ruco, L. P. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90008-u · Cited by 1,088 · see citing works
Fotsis, T., Zhang, Y., Pepper, M. S., Adlercreutz, H., Montesano, R., Nawroth, P. P., & Schweigerer, L. (1994) · Nature · doi:10.1038/368237a0 · Cited by 730 · see citing works
(1996) · Nature Medicine · doi:10.1038/nm1196-1267 · Cited by 431 · see citing works
Freeman, M. R., Schneck, F. X., Gagnon, M. L., Corless, C. L., Söker, S., Niknejad, K., Peoples, G. E., & Klagsbrun, M. (1995) · PubMed · Cited by 393 · see citing works
Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · PubMed · Cited by 363 · see citing works
Kono, K., Salazar‐Onfray, F., Petersson, M., Hansson, J., Masucci, G. V., Wasserman, K., Nakazawa, T., Anderson, P., & Kiessling, R. W. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260620 · Cited by 360 · see citing works
Alternative Vascularization Mechanisms in Cancer
Döme, B., Hendrix, M. J. C., Paku, S., Tóvári, J., & Tímár, J. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060302 · Cited by 359 · see citing works
Self-citationLosordo, D. W., & Isner, J. M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.6 · Cited by 354 · see citing works
Induction of transforming growth factor-α in activated human alveolar macrophages
Madtes, D. K., Raines, E. W., Sakaríassen, K. S., Assoian, R. K., Sporn, M. B., Bell, G. I., & Ross, R. (1988) · Cell · doi:10.1016/0092-8674(88)90390-x · Cited by 345 · see citing works
Miescher, S., Whiteside, T. L., Carrel, S., & Fliedner, V. E. V. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.5.1899 · Cited by 312 · see citing works
Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer
Curiel, T. J., Cheng, P. J., Mottram, P. J., Alvarez, X. A., Moons, L., Evdemon-Hogan, M., Wei, S., Zou, L., Kryczek, I., Hoyle, G. W., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1272 · Cited by 297 · see citing works
Ladányi, A., Kiss, J., Somlai, B., Gilde, K., Fejôs, Z., Mohos, A., Gaudi, I., & Tı́már, J. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0286-3 · Cited by 287 · see citing works
Self-citationEstrogen-Receptor–Mediated Inhibition of Human Endothelial Cell Apoptosis
Spyridopoulos, I., Sullivan, A. B., Kearney, M., Isner, J. M., & Losordo, D. W. (1997) · Circulation · doi:10.1161/01.cir.95.6.1505 · Cited by 285 · see citing works
Prognostic value of tumor‐associated macrophage count in human bladder cancer
Hanada, T., Nakagawa, M., Emoto, A., Nomura, T., Nasu, N., & Nomura, Y. (2000) · International Journal of Urology · doi:10.1046/j.1442-2042.2000.00190.x · Cited by 284 · see citing works
Tumor-infiltrating macrophages (CD68(+) cells) and prognosis in malignant uveal melanoma.
Mäkitie, T., Summanen, P. A., Tarkkanen, A. H. A., & Kivelä, T. (2001) · PubMed · Cited by 273 · see citing works
Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000115)85:2%3c182::aid-ijc6%3e3.0.co;2-m · Cited by 254 · see citing works
2-Methoxyestradiol: an Endogenous Antiangiogenic and Antiproliferative Drug Candidate
Pribluda, V. S., Gubish, E. R., Gubish, E. R., LaVallee, T. M., Treston, A. M., Swartz, G. M., & Green, S. J. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026543018478 · Cited by 240 · see citing works
A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells.
Qin, Z., Schwartzkopff, J., Pradera, F., Kammertoens, T., Seliger, B., Pircher, H., & Blankenstein, T. J. F. (2003) · PubMed · Cited by 234 · see citing works
Expression of an Estrogen Receptor by Human Coronary Artery and Umbilical Vein Endothelial Cells
Kim‐Schulze, S., McGowan, K. A., Hubchak, S. C., Cid, M. C., Martin, M. B., Kleinman, H. K., Greene, G. L., & Schnaper, H. W. (1996) · Circulation · doi:10.1161/01.cir.94.6.1402 · Cited by 218 · see citing works
Adjustment of children and adolescents to parental cancer: Parents' and children's perspectives
Welch, A. S., Wadsworth, M. E., & Compas, B. E. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960401)77:7 · Cited by 217 · see citing works
Cytokine networks in solid human tumors: regulation of angiogenesis
Leek, R., Harris, A. L., & Lewis, C. E. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.4.423 · Cited by 206 · see citing works
Thin Malignant Melanomas With Regression and Metastases
Ronan, S. G. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660340088026 · Cited by 186 · see citing works
Mabjeesh, N. J., Willard, M. T., Frederickson, C. E., Zhong, H., & Simons, J. W. (2003) · PubMed · Cited by 173 · see citing works
Piras, F., Colombari, R., Minerba, L., Murtas, D., Floris, C., Maxia, C., Corbu, A., Perra, M. T., & Sirigu, P. (2005) · Cancer · doi:10.1002/cncr.21283 · Cited by 169 · see citing works
Signaling defects in T lymphocytes of patients with malignancy
Whiteside, T. L. (1999) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050585 · Cited by 164 · see citing works
Ladányi, A., Somlai, B., Gilde, K., Fejôs, Z., Gaudi, I., & Tı́már, J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1161-03 · Cited by 157 · see citing works
Self-citationBiological implications of macrophage infiltration in human tumor angiogenesis
Ono, M., Torisu, H., Fukushi, J.-I., Nishie, A., & Kuwano, M. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800051101 · Cited by 157 · see citing works
Inflammatory cell infiltrates in human melanoma at different stages of tumor progression
Bröcker, E. B., Zwadlo, G., Holzmann, B., Macher, E., & Sorg, C. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910410415 · Cited by 153 · see citing works
Saito, H., Tsujitani, S., Ikeguchi, M., Maeta, M., & Kaibara, N. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.725 · Cited by 142 · see citing works
Gross, J., Azizkhan, R. G., Biswas, C., Bruns, R. R., Hsieh, D. S. T., & Folkman, J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1176 · Cited by 136 · see citing works
Tumor Vascularity in the Prognostic Assessment of Primary Cutaneous Melanoma
Kashani–Sabet, M., Sagebiel, R. W., Ferreira, C. M. M., Nosrati, M., & Miller, J. R. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.082 · Cited by 134 · see citing works
Endothelial Cells of Tumor Vessels: Abnormal but not Absent
McDonald, D. M., & Foss, A. J. E. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026529222845 · Cited by 127 · see citing works
Vascularization of cutaneous melanoma involves vessel co‐option and has clinical significance
Döme, B., Paku, S., Somlai, B., & Tı́már, J. (2002) · The Journal of Pathology · doi:10.1002/path.1124 · Cited by 124 · see citing works
Self-citationThe role of dendritic cell precursors in tumour vasculogenesis
Coukos, G., Benencia, F., Buckanovich, R. J., & Conejo-Garcia, J. R. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602476 · Cited by 111 · see citing works
Marcoval, J., Moreno, A., Graells, J., Vidal, A., Escribà, J. M., García‐Ramírez, M., & Fabra, À. (1997) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1997.tb01583.x · Cited by 109 · see citing works
Phenotype and functions of intratumoral macrophages
McBride, W. H. (1986) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(86)90011-9 · Cited by 106 · see citing works
Varney, M. L., Johansson, S. L., & Singh, R. K. (2005) · Melanoma Research · doi:10.1097/00008390-200510000-00010 · Cited by 105 · see citing works
Tumor vascularity is not a prognostic factor for malignant melanoma of the skin.
BUSAM, K. J., Berwick, M., Blessing, K., Fandrey, K., Kang, S., Karaoli, T., Fine, J., Cochran, A. J., White, W. L., & Rivers, J. K. (1995) · Europe PMC (PubMed Central) · Cited by 100 · see citing works
Inoshima, N., Nakanishi, Y., Minami, T., Izumi, M., Takayama, K., Yoshino, I., & Hara, N. (2002) · PubMed · Cited by 99 · see citing works
Regressing thin cutaneous malignant melanomas (< or = 1.0 mm) are associated with angiogenesis.
Barnhill, R. L., & Levy, M. A. (1993) · PubMed · Cited by 93 · see citing works
Arici, A. M., Senturk, L. M., Seli, E. U., Bahtiyar, M. O., & Kim, G. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.1.85 · Cited by 91 · see citing works
Angiogenesis is prognostically important in vertical growth phase melanomas.
Straume, O., Salvesen, H. B., & Akslen, L. A. (1999) · International Journal of Oncology · doi:10.3892/ijo.15.3.595 · Cited by 80 · see citing works
Lackner, C., Jukić, Z., Tsybrovskyy, O., Jatzko, G. R., Wette, V., Höefler, G., Klimpfinger, M., Denk, H., & Zatloukal, K. (2004) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-004-1051-z · Cited by 70 · see citing works
Arvilommi, A., Salmi, M., Kalimo, K., & Jalkanen, S. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260415 · Cited by 68 · see citing works
Peng, S. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i41.6521 · Cited by 66 · see citing works
Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells
Seli, E. U., Pehlivan, T., Selam, B., García-Velasco, J. A., & Arici, A. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03223-x · Cited by 65 · see citing works
Prognostic Value of HLA-DR Expression and Dendritic Cell Infiltration in Gastric Cancer
Ishigami, S., Aikou, T., Natsugoe, S., Hokita, S., Iwashige, H., Tokushige, M., & Sonoda, S. (1997) · Oncology · doi:10.1159/000011837 · Cited by 65 · see citing works
Colombel, M. C., Filleur, S., Fournier, P. G. J., Arnold, C., Guglielmi, J., Courtin, A., Degeorges, A., Serre, C. M., Bouvier, R., Clézardin, P., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.300.65.1 · Cited by 63 · see citing works
Seo, K. H., Lee, H.-S., Jung, B., Ko, H.-M., Choi, J., Park, S. J., Choi, I.-H., Lee, H.-K., & Im, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2774 · Cited by 61 · see citing works
In vitro and in vivo antitumor effect of 2‐methoxyestradiol on human melanoma
Dobos, J., Tı́már, J., Bocsi, J., Burián, Z., Nagy, K., Barna, G., Peták, I., & Ladányi, A. (2004) · International Journal of Cancer · doi:10.1002/ijc.20473 · Cited by 53 · see citing works
Self-citationPrehn, R. T. (1996) · PubMed · Cited by 45 · see citing works
Davidson, B., Goldberg, I., Gotlieb, W. H., Lerner‐Geva, L., Ben‐Baruch, G., Agulansky, L., Novikov, I., & Kopolovic, J. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.1999.780312.x · Cited by 43 · see citing works
Prognostic value of tumour vascularity in primary melanoma
llmonen, S., Kariniemi, A. L., Vlaykova, T. I., Muhonen, T. T., Pyrhönen, S. O., & Asko-Seljavaara, S. L. (1999) · Melanoma Research · doi:10.1097/00008390-199906000-00009 · Cited by 37 · see citing works
Microvessel density for melanoma prognosis
Depasquale, I., & Thompson, W. D. (2005) · Histopathology · doi:10.1111/j.1365-2559.2005.02193.x · Cited by 37 · see citing works
Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma
Forster‐Horváth, C., Döme, B., Paku, S., Ladányi, A., Somlai, B., Jalkanen, S., & Tı́már, J. (2004) · Melanoma Research · doi:10.1097/00008390-200404000-00010 · Cited by 32 · see citing works
Self-citationIshigami, S., Natsugoe, S., Matsumoto, M., Okumura, H., Sakita, H., Nakashima, S., Takao, S., & Aikou, T. (2003) · Oncology Reports · doi:10.3892/or.10.5.1237 · Cited by 27 · see citing works
Davidson, B., Goldberg, I., Gotlieb, W. H., et al. (1999) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/j.1600-0412.1999.780312.x · Cited by 19 · see citing works
A research shortcut from a common cold virus to human cancer
Harlow, E. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960801)78:3 · Cited by 5 · see citing works
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Sorted by citations
T cell–induced CSF1 promotes melanoma resistance to PD1 blockade
Neubert, N. J., Schmittnaegel, M., Bordry, N., Nassiri, S., Wald, N., Martignier, C., Tillé, L., Homicsko, K., Damsky, W., Maby-El Hajjami, H., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan3311 · Cited by 308 · see citing works
Jensen, T. Ø., Schmidt, H., Møller, H. J., Høyer, M., Maniecki, M. B., Sjoegren, P., Christensen, I. J., & Steiniche, T. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.9919 · Cited by 299 · see citing works
Prognostic impact of B-cell density in cutaneous melanoma
Ladányi, A., Kiss, J., Mohos, A., Somlai, B., Liszkay, G., Gilde, K., Fejôs, Z., Gaudi, I., Dobos, J., & Tı́már, J. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1071-x · Cited by 201 · see citing works
Self-citationPrognostic and predictive significance of immune cells infiltrating cutaneous melanoma
Ladányi, A. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12371 · Cited by 168 · see citing works
Self-citationHypoxia Signaling in Cancer: From Basics to Clinical Practice
Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110 · see citing works
Self-citationSalmi, S., Siiskonen, H., Sironen, R. K., Tyynelä-Korhonen, K., Hirschovits-Gerz, B., Valkonen, M., Auvinen, P., & Pasonen‐Seppänen, S. (2018) · Melanoma Research · doi:10.1097/cmr.0000000000000522 · Cited by 90 · see citing works
Döme, B., Tı́már, J., Ladányi, A., Paku, S., Renyi-Vamos, F., Klepetko, W., Láng, G., Döme, P., Bogos, K., & Tóvári, J. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2008.06.009 · Cited by 63 · see citing works
Self-citationPastushenko, I., Vermeulen, P., Carapeto, F. J., den Eynden, G. V., Rutten, A., Ara, M., Dirix, L. Y., & Laere, S. V. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12688 · Cited by 61 · see citing works
Rao, U. N. M., Lee, S. J., Luo, W., Mihm, M. C., & Kirkwood, J. M. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcptxmefovywda6 · Cited by 56 · see citing works
Helfrich, I., & Schadendorf, D. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.01.003 · Cited by 56 · see citing works
Immune-related biomarkers for diagnosis/prognosis and therapy monitoring of cutaneous melanoma
Neagu, M. T., Constantin, C., & Tănase, C. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.81 · Cited by 48 · see citing works
Torisu‐Itakura, H., Schoellhammer, H. F., Sim, M., Irie, R. F., Hausmann, S., Raum, T., Baeuerle, P. A., & Morton, D. L. (2011) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3182307fd8 · Cited by 41 · see citing works
Reduced CTL motility and activity in avascular tumor areas
Manaster, Y., Shipony, Z., Hutzler, A., Kolesnikov, M., Avivi, C., Shalmon, B., Barshack, I., Besser, M. J., Feferman, T., & Shakhar, G. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02361-5 · Cited by 30 · see citing works
Samaniego, R., Estecha, A., Relloso, M., Longo, N., Escat, J. L., Longo-Imedio, I., Avilés, J. A., del Pozo, M. Á., Puig‐Kröger, A., & Sánchez‐Mateos, P. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.88 · Cited by 28 · see citing works
Prediction of nitric oxide concentrations in melanomas
Chin, M. P., & Deen, W. M. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.09.003 · Cited by 23 · see citing works
Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications
Pastushenko, I., Vermeulen, P. B., den Eynden, G. G. V., Rutten, A., Carapeto, F. J., Dirix, L. Y., & Laere, S. V. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12973 · Cited by 19 · see citing works
Shi, L., Lei, D., Ma, C., Xu, F., Li, Y., Wang, Y., Cong, N., Liu, D., & Pan, X. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800409 · Cited by 18 · see citing works
Sebestyén, T., Mohos, A., Liszkay, G., Somlai, B., Gaudi, I., & Ladányi, A. (2018) · Melanoma Research · doi:10.1097/cmr.0000000000000457 · Cited by 16 · see citing works
Self-citationPerivoliotis, K., Ntellas, P., Dadouli, K., Koutoukoglou, P., Ιωάννου, Μ., & Tepetes, K. (2017) · Journal of Skin Cancer · doi:10.1155/2017/2049140 · Cited by 13 · see citing works
Tissue-Specific Homing of Immune Cells in Malignant Skin Tumors
Jókai, H., Marschalkó, M., Csomor, J., Szakonyi, J., Kontár, O., Barna, G., Kárpáti, S., & Holló, P. (2012) · Pathology & Oncology Research · doi:10.1007/s12253-012-9529-5 · Cited by 8 · see citing works
Ladányi, A., Kapuvári, B., Papp, E., Tóth, E., Lövey, J., Horváth, K., Gődény, M., & Remenár, É. (2018) · Head & Neck · doi:10.1002/hed.25546 · Cited by 7 · see citing works
Self-citationBozdoğan, N., Bozdoğan, Ö., Pak, I., & Atasoy, P. (2010) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2009.04365.x · Cited by 6 · see citing works
Sex-dependent liver colonization of human melanoma in SCID mice—role of host defense mechanisms
Dobos, J., Mohos, A., Tóvári, J., Rásó, E., Lőrincz, T., Zádori, G., Tı́már, J., & Ladányi, A. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9554-5 · Cited by 5 · see citing works
Self-citationStromal inflammatory cells are associated with poorer prognosis in primary cutaneous melanoma
Yun, S. J., Liu, S., Buckley, M. E., Wang, T., Jin, S., Karakousis, G. C., Peters, M. G., Elder, D. E., Gimotty, P. A., & Xu, X. (2019) · Human Pathology · doi:10.1016/j.humpath.2019.03.008 · Cited by 4 · see citing works
Mohamed, A., Caltharp, S. A., Wang, J., Cohen, C., & Farris, A. B. (2013) · Journal of Analytical Oncology · doi:10.6000/1927-7229.2013.02.03.2 · Cited by 3 · see citing works
Stolfo, J. B., & MOTTA, A. C. D. (2024) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202420230441 · Cited by 2 · see citing works
Vaszkularizációt befolyásoló tényezők vizsgálata emberi melanómában
Kiss, J. (2008) · Magyar Onkológia · doi:10.1556/monkol.52.2008.4.8 · Cited by 1 · see citing works
Self-citationExamination of Different Factors Influencing the Vascularization of Human Cutaneous Melanoma
Kiss, J. (2008) · Hungarian Medical Journal · doi:10.1556/hmj.2.2008.2.28332 · Cited by 1 · see citing works
Self-citationMacrophage Response to Simulated Solar Radiation in the Development of Human Malignant Melanoma
Chu, S., Petukhova, T. A., Bordeaux, J. S., McCormick, T. S., & Cooper, K. D. (2021) · Archives of Clinical & Experimental Dermatology · doi:10.46527/2583-6374.119 · Cited by 1 · see citing works
Mesenchymal Cells Hold the Key to Immune Cell Recruitment to and Migration within Melanoma
Beaumont, K. A., Munoz, M. A., & Weninger, W. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.206
Ritchey, J. D., Karmaus, W., Sabo‐Attwood, T., Steck, S. E., & Zhang, H. (2013) · Journal of Analytical Oncology · doi:10.6000/1927-7229.2013.02.03.3
Lydon, J. P., Johnson, J. M., Griffiths, D. A., Munroe, K. J., Harper, J. W., & Thurberg, B. L. (2010)
Aboelnasr, L. S., Meehan, H., Saso, S., Yagüe, E., & El-Bahrawy, M. A. (2024) · Cancers · doi:10.3390/cancers16213611
Mok, H. Y., Ooi, E. H., Chiew, Y. S., Pamidi, N., & Ooi, E. T. (2025) · International Journal of Heat and Mass Transfer · doi:10.1016/j.ijheatmasstransfer.2025.127345
- Authors
- Kiss, J., Tímár, J., Somlai, B., Gilde, K., Fejős, Z., Gaudi, I., & Ladányi, A.
- Affiliations
- National Institute of Oncology (HU)
- Semmelweis University (HU)
- Corresponding author
- Ladányi, Andrea
- ORCID
- Ladányi, Andrea
- Venue
- Pathology & Oncology Research
- Published
- 2007-03
- Volume
- 13
- Issue
- 1
- Pages
- 21-31
- ISSN
- 1219-4956 (ISSN-L)
- 1532-2807
- OpenAlex
- W2148920220
- Cited by
- 34
- References
- 66
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pathology & Oncology Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cutaneous melanoma, microvessel density, tumor vascularization, tumor-infiltrating lymphocytes, CD3+ T cells, CD8+ T cells, macrophage infiltration, CD68, dendritic cells, B cells, visceral metastases, tumor thickness, sex differences, host immune response
- MeSH terms
- Female, Humans, Immunohistochemistry, Macrophages, Male, Melanoma, Skin Neoplasms, T-Lymphocytes, Lymphocytes, Tumor-Infiltrating
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