Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Wong, E. H. F., Kemp, J. A., Priestley, T., Knight, A. R., Woodruff, G. N., & Iversen, L. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.7104 · Cited by 1,820 · see citing works

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541 · see citing works

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works

Rat hippocampal neurons in dispersed cell culture.

Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110 · see citing works

Neurotoxicity induces cleavage of p35 to p25 by calpain

Lee, M.-S., Kwon, Y. T., Li, M., Peng, J., Friedlander, R. M., & Tsai, L. (2000) · Nature · doi:10.1038/35012636 · Cited by 1,057 · see citing works

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006 · see citing works

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

LaFerla, F. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn960 · Cited by 970 · see citing works

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Tsai, L., Delalle, I., Caviness, V. S., Chae, T. H., & Harlow, E. (1994) · Nature · doi:10.1038/371419a0 · Cited by 923 · see citing works

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

Kishimoto, T., Akira, S., & Taga, T. (1992) · Science · doi:10.1126/science.1411569 · Cited by 883 · see citing works

Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

Viviani, B., Bartesaghi, S., Gardoni, F., Vezzani, A., Behrens, M. M., Bartfai, T., Binaglia, M., Corsini, E., Di Luca, M., Galli, C. L., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08692.2003 · Cited by 876 · see citing works

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works

The soluble interleukin 6 receptor: mechanisms of production and implications in disease

Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N., & Fuller, G. M. (2001) · The FASEB Journal · doi:10.1096/fj.99-1003rev · Cited by 684 · see citing works

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works

Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials

Gadient, R. A., & Otten, U. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00021-x · Cited by 481 · see citing works

Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

Quintanilla, R. A., Orellana, D. I., González-Billault, C., & Maccioni, R. B. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.002 · Cited by 455 · see citing works

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

Mattson, M. P., Tomaselli, K. J., & Rydel, R. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90295-x · Cited by 379 · see citing works

HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

Merrill, J. E., & Chen, I. S. Y. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.10.2065887 · Cited by 355 · see citing works

Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNFα and LIF in the rat brain

Minami, M., Kuraishi, Y., & Satoh, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80225-6 · Cited by 333 · see citing works

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T., Morooka, T., Ogawa, S., & Nishida, E. (2001) · Nature Cell Biology · doi:10.1038/35074516 · Cited by 322 · see citing works

β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

Apelt, J., & Schliebs, R. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03176-0 · Cited by 287 · see citing works

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

Wang, J., Liu, S., Fu, Y., Wang, J. H.-C., & Lu, Y. (2003) · Nature Neuroscience · doi:10.1038/nn1119 · Cited by 270 · see citing works

Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration

Sriram, K., Benkovic, S. A., Hebert, M. A., Miller, D. B., & O'Callaghan, J. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309304200 · Cited by 261 · see citing works

Regulation of NMDA receptors by cyclin-dependent kinase-5

Li, B., Sun, M., Zhang, L., Takahashi, S., Ma, W., Vinadé, L., Kulkarni, A. B., Brady, R. O., & Pant, H. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211428098 · Cited by 260 · see citing works

Costimulatory Effects of Interferon-γ and Interleukin-1β or Tumor Necrosis Factor α on the Synthesis of Aβ1-40 and Aβ1-42 by Human Astrocytes

Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., & Grubeck-Loebenstein, B. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0321 · Cited by 258 · see citing works

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.

Sengupta, T. K., Talbot, E. S., Scherle, P., & Ivashkiv, L. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.19.11107 · Cited by 245 · see citing works

Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death

Alvarez, A. R., Toro, R., Cáceres, A., & Maccioni, R. B. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01279-x · Cited by 228 · see citing works

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

Bo, R. D., Angeretti, N., Lucca, E., Simoni, M. G. D., & Forloni, G. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11384-9 · Cited by 205 · see citing works

Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

Mehlhorn, G., Hollborn, M., & Schliebs, R. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00012-5 · Cited by 199 · see citing works

Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

Gitter, B. D., Cox, L. M., Rydel, R. E., & May, P. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10738 · Cited by 178 · see citing works

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.

Sudbeck, E. A., Liu, X., Narla, R. K., Mahajan, S., Ghosh, S., Mao, C., & Uckun, F. M. (1999) · PubMed · Cited by 166 · see citing works

Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons

Qiu, Z. J., Sweeney, D. D., Netzeband, J. G., & Gruol, D. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10445.1998 · Cited by 159 · see citing works

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

Gijbels, K., Damme, J. V., Proost, P., Put, W., Carton, H., & Billiau, A. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200134 · Cited by 148 · see citing works

Interleukin-6 Induced Basic Fibroblast Growth Factor-Dependent Angiogenesis in Basal Cell Carcinoma Cell Line via JAK/STAT3 and PI3-Kinase/Akt Pathways

Jee, S., Chu, C., Chiu, H.-C., Huang, Y., Tsai, W.-L., Liao, Y., & Kuo, M. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23497.x · Cited by 137 · see citing works

Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

Sengupta, T. K., Schmitt, E. M., & Ivashkiv, L. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9499 · Cited by 132 · see citing works

Interleukin-6 is elevated in plasma in multiple sclerosis

Krei, K., Fredrikson, S., Fontana, A., & Link, H. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90020-8 · Cited by 130 · see citing works

A Cdk5–p35 Stable Complex Is Involved in the β-Amyloid-Induced Deregulation of Cdk5 Activity in Hippocampal Neurons

Alvarez, A. R., Muñoz, J. P., & Maccioni, R. B. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5152 · Cited by 125 · see citing works

Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons

Qiu, Z., Parsons, K., & Gruol, D. L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06688.1995 · Cited by 97 · see citing works

Interleukin 6 production in experimental cerebral malaria: modulation by anticytokine antibodies and possible role in hypergammaglobulinemia.

Grau, G. E., Frei, K., Piguet, P. F., Fontana, A., Heremans, H., Billiau, A., VASSALLI, P., & Lambert, P. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.5.1505 · Cited by 84 · see citing works

Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia

Gadient, R. A., & Otten, U. (1996) · Brain Research · doi:10.1016/0006-8993(96)00264-8 · Cited by 83 · see citing works

IL-6-mediated events in Alzheimer's disease pathology

Bauer, J., Strauss, S., Volk, B., & Berger, T. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90148-m · Cited by 62 · see citing works

Effect of a carboxy-terminal fragment of the alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells

Chong, Y.-H. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00936-3 · Cited by 59 · see citing works

Expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat adrenal medulla.

Gadient, R., Lachmund, A., Unsicker, K., & Otten, U. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11708-5 · Cited by 50 · see citing works

Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture

Holliday, J., Parson, K., Curry, J., Lee, S. Y., & Gruol, D. L. (1995) · Brain Research · doi:10.1016/0006-8993(94)01417-g · Cited by 40 · see citing works

Interleukin‐6 and Interleukin‐6 Receptor mRNA Expression in Rat Central Nervous Systema

Gadient, R. A., & Otten, U. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32348.x · Cited by 30 · see citing works

Cytosolic [Ca(2+)] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells.

Quintanilla, R., Porras, O., Castro, J., & Barros, L. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0135 · Cited by 30 · see citing works

Increased Gene Expression of Interleukin-1 α and Interleukin-6 in Rat Primary Glial Cells Induced by β-Amyloid Fragment

Toro, V. C., Tehranian, R., Zetterström, M., Eriksson, G., Langel, Ü., Bartfai, T., & Lverfeldt, K. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:3:241 · Cited by 18 · see citing works

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

Vezzani, A., & Viviani, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.027 · Cited by 670 · see citing works

Glial contributions to neurodegeneration in tauopathies

Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409 · see citing works

Interleukin-6, a mental cytokine

Spooren, A., Kolmus, K., Laureys, G., Clinckers, R., De Keyser, J., Haegeman, G., & Gerlo, S. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.002 · Cited by 352 · see citing works

The role of JAK-STAT signaling within the CNS

Nicolas, C. S., Amici, M., Bortolotto, Z. A., Doherty, A. J., Csaba, Z., Fafouri, A., Dournaud, P., Gressèns, P., Collingridge, G. L., & Peineau, S. (2013) · JAK-STAT · doi:10.4161/jkst.22925 · Cited by 352 · see citing works

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

Li, C., Zhao, R., Gao, K., Wei, Z. Z., Yin, M. Y., Lau, L. T., Chui, D., & Yu, A. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604543 · Cited by 291 · see citing works

The Role of Neuroimmunomodulation in Alzheimer's Disease

Maccioni, R. B., Rojo, L. E., Fernández, J. A., & Kuljiš, R. O. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03972.x · Cited by 261 · see citing works

Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors

Wei, H., Chadman, K. K., McCloskey, D. P., Sheikh, A. M., Malik, M. N., Brown, W. T., & Li, X. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.01.011 · Cited by 257 · see citing works

The Jak/STAT pathway is involved in synaptic plasticity

Nicolas, C. S., Peineau, S., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, V. J., Hildebrandt, L., Seaton, G., Choi, S.-L., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.024 · Cited by 246 · see citing works

Growth hormone and cognitive function

Nyberg, F., & Hallberg, M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.78 · Cited by 235 · see citing works

JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Sarapultsev, A., Gusev, E., Komelkova, M. V., Utepova, I. A., Luo, S., & Hu, D. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00151-1 · Cited by 226 · see citing works

Interleukin-6 Protects Retinal Ganglion Cells from Pressure-Induced Death

Sappington, R. M., Chan, M. F., & Calkins, D. J. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1407 · Cited by 164 · see citing works

Selective Interaction of Lansoprazole and Astemizole with Tau Polymers: Potential New Clinical Use in Diagnosis of Alzheimer's Disease

Rojo, L. E., Alzate‐Morales, J. H., Saavedra, I. N., Davies, P., & Maccioni, R. B. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1262 · Cited by 141 · see citing works

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

Lee, Y., Choi, D., Choi, I. S., Kim, K. H., Kim, Y. H., Kim, H. M., Lee, K., Cho, W. G., Jung, J. K., Han, S., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-35 · Cited by 133 · see citing works

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

Sama, D. M., & Norris, C. M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.008 · Cited by 126 · see citing works

Biomarkers for Alzheimer’s Disease

Guzman-Martinez, L., Maccioni, R. B., Farías, G. A., Fuentes, P., & Navarrete, L. P. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190517121140 · Cited by 87 · see citing works

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

Buduo, C. A. D., Abbonante, V., Marty, C., Moccia, F. D., Rumi, E., Pietra, D., Soprano, P. M., Lim, D., Cattaneo, D., Iurlo, A., et al. (2019) · Blood · doi:10.1182/blood.2019001103 · Cited by 74 · see citing works

Neuroglobin Overexpression in Cultured Human Neuronal Cells Protects Against Hydrogen Peroxide Insult via Activating Phosphoinositide-3 Kinase and Opening the Mitochondrial KATP Channel

Antao, S., Duong, T. T. H., Aran, R., & Witting, P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2977 · Cited by 75 · see citing works

Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

Park, S.-J., Shin, E., Min, S. S., An, J., Li, Z., Chung, Y. H., Jeong, J. H., Bach, J., Nah, S.-Y., Kim, W.-K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.39 · Cited by 67 · see citing works

Ethanol and Cytokines in the Central Nervous System

Roberto, M., Patel, R. R., & Bajo, M. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_77 · Cited by 71 · see citing works

Roles of Cholesterol and Lipids in the Etiopathogenesis ofAlzheimer′s Disease

Rojo, L. E., Sjöberg-Herrera, M. K., Hernández, P., Zambrano, C. A., & Maccioni, R. B. (2006) · BioMed Research International · doi:10.1155/jbb/2006/73976 · Cited by 57 · see citing works

Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK

Wang, X., Peng, Y.-P., Lu, J., Cao, B., & Qiu, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.051 · Cited by 57 · see citing works

Mechanism of the JAK2/STAT3-CAV-1-NR2B signaling pathway in painful diabetic neuropathy

Chuan-da, L., Zhao, J., Chen, J., Lu, J., Zhang, M., Huang, Q., Cao, Y., Jia, G., Tao, Y., Li, J., et al. (2019) · Endocrine · doi:10.1007/s12020-019-01880-6 · Cited by 58 · see citing works

Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions

Khera, R., Mehan, S., Kumar, S., Sethi, P., Bhalla, S., & Prajapati, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02819-1 · Cited by 54 · see citing works

Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action

Ahmad, I., & Hoda, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117350 · Cited by 53 · see citing works

Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation

Hopp, S. C., D’Angelo, H. M., Royer, S. E., Kaercher, R. M., Crockett, A. M., Adzovic, L., & Wenk, G. L. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0262-3 · Cited by 51 · see citing works

Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits

Guan, P.-P., Cao, L., Yang, Y., & Wang, P. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.757515 · Cited by 44 · see citing works

Biomarkers for Alzheimer's disease

Pauwels, E. K. J., Volterani, D., & Marlani, G. (2009) · Drug News & Perspectives · doi:10.1358/dnp.2009.22.3.1354128 · Cited by 42 · see citing works

Neurotoxins and neurotoxicity mechanisms. an overview

Segura‐Aguilar, J., & Kostrzewa, R. M. (2006) · Neurotoxicity Research · doi:10.1007/bf03033362 · Cited by 41 · see citing works

Neuroprotection of Interleukin-6 Against NMDA-Induced Apoptosis and Its Signal-Transduction Mechanisms

Liu, Z., Qiu, Y.-H., Li, B., Ma, S.-H., & Peng, Y.-P. (2011) · Neurotoxicity research · doi:10.1007/s12640-010-9215-x · Cited by 41 · see citing works

Interleukin-6 in retinal diseases: From pathogenesis to therapy.

Xiao, R.-H., Lei, C., Zhang, Y., & Zhang, M. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109556 · Cited by 34 · see citing works

Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

Richardson, P. J., Smith, D. P., de Giorgio, A., Snetkov, X., Almond-Thynne, J., Cronin, S., Mead, R. J., McDermott, C. J., & Shaw, P. J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00380-y · Cited by 34 · see citing works

Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia

Nagel, S., Papadakis, M., Pfleger, K., Grond-Ginsbach, C., Buchan, A. M., & Wagner, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.048 · Cited by 32 · see citing works

The Role of the Somatotrophic Axis in Neuroprotection and Neuroregeneration of the Addictive Brain

Nyberg, F. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)88014-8 · Cited by 32 · see citing works

High fatty acids modulate P2X7 expression and IL-6 release via the p38 MAPK pathway in PC12 cells

Xu, H., Wu, B., Jiang, F.-Q., Xiong, S., Zhang, B., Li, G., Liu, S., Gao, Y., Xu, C., Tu, G., et al. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.02.002 · Cited by 31 · see citing works

Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons

Sharma, A., Brenner, M., Jacob, A., Marambaud, P., & Wang, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02368-z · Cited by 30 · see citing works

Trans-Resveratrol Attenuates High Fatty Acid-Induced P2X7 Receptor Expression and IL-6 Release in PC12 Cells: Possible Role of P38 MAPK Pathway

Xu, H., Xiong, C., He, L., Wu, B., Peng, L., Cheng, Y., Jiang, F.-Q., Tan, L., Tang, L. F., Tu, Y., et al. (2014) · Inflammation · doi:10.1007/s10753-014-0036-6 · Cited by 30 · see citing works

A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis

Sahu, A., Ghosh, R., Deshpande, G., & Prasad, M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006542 · Cited by 30 · see citing works

Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer’s Disease

Sharma, A., Brenner, M., & Wang, P. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02075-1 · Cited by 28 · see citing works

TRIM8-driven transcriptomic profile of neural stem cells identified glioma-related nodal genes and pathways

Venuto, S., Castellana, S., Monti, M., Appolloni, I., Fusilli, C., Fusco, C., Pucci, P., Malatesta, P., Mazza, T., Merla, G., et al. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.12.001 · Cited by 26 · see citing works

Neuroprotection: VEGF, IL-6, and clusterin: the dark side of the moon

Pucci, S., Mazzarelli, P., Missiroli, F., Regine, F., & Ricci, F. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)01138-2 · Cited by 26 · see citing works

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6

Anesten, F., Holt, M. K., Schéle, E., Pálsdóttir, V., Reimann, F. M., Gribble, F. M., Safari, C., Skibicka, K. P., Trapp, S., & Jansson, J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2015 · Cited by 25 · see citing works

Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells

Bick, R. J., Poindexter, B. J., Kott, M. M., Liang, Y. A., Dinh, K., Kaur, B., Bick, D. L. M., Doursout, M., & Schiess, M. C. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.081 · Cited by 22 · see citing works

Prolonged STAT1 activation in neurons drives a pathological transcriptional response

Clark, D. N., O’Neil, S. M., Xu, L., Steppe, J. T., Savage, J. T., Raghunathan, K., & Filiano, A. J. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578168 · Cited by 19 · see citing works

Is the JAK-STAT Signaling Pathway Involved in the Pathogenesis of Depression?

Gałecka, M., Szemraj, J., Su, K., Halaris, A. E., Maes, M. H. J., Skiba, A., Gałecki, P., & Bliźniewska-Kowalska, K. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11072056 · Cited by 20 · see citing works

Interleukin-6: A neuro-active cytokine contributing to cognitive impairment in Duchenne muscular dystrophy?

Stephenson, K. A., Rae, M. G., & O'Malley, D. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155134 · Cited by 15 · see citing works

Neuroinflammation in Epilepsy

Dingledine, R. J., Varvel, N. H., Ravizza, T., & Vezzani, A. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0030 · Cited by 13 · see citing works

Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway

Sharma, A., Sari, E. N., Lee, Y., Patel, S. P., Brenner, M., Marambaud, P., & Wang, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03273-3 · Cited by 12 · see citing works

Postoperative 24-h Acute Sleep Deprivation Improves Learning and Memory Through Inhibition of Tau Phosphorylation in the Hippocampal Neurons of Splenectomized Rats

Zhang, Y.-W., Li, X., Tan, W., Fang, B., & Ma, H. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s254449 · Cited by 10 · see citing works

GBE50 Attenuates Inflammatory Response by Inhibiting the p38 MAPK and NF‐κB Pathways in LPS‐Stimulated Microglial Cells

He, G.-Y., Yuan, C., Li, H., Xu, Y., & Zhang, Z. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/368598 · Cited by 10 · see citing works

The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex

Jang, S.-S., Choi, J., Im, D. S., Park, S., Park, J., Park, S. M., Joe, E.-H., Jou, I., & Suh, Y. H. (2013) · Neuroreport · doi:10.1097/wnr.0000000000000022 · Cited by 9 · see citing works

Ciliary neurotrophic factor signaling in the rat orbitofrontal cortex ameliorates stress-induced deficits in reversal learning

Girotti, M., Silva, J. D., George, C. M., & Morilak, D. A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107791 · Cited by 8 · see citing works

Neuroprotective compounds from marine invertebrates

Rivai, B., & Umar, A. K. (2023) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-023-00407-3 · Cited by 9 · see citing works

What Have We Learned from the Tau Hypothesis?

Maccioni, R. B., Farias, G. A., Rojo, L. E., Sekler, M. A., & Kuljiš, R. O. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_5 · Cited by 7 · see citing works

Molecular Targets in the Rational Design of AD Specific PET Tracers: Tau or Amyloid Aggregates?

Rojo, L. E., Gaspar, P. A., & Maccioni, R. B. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717203 · Cited by 6 · see citing works

Paths to hippocampal damage in neuromyelitis optica spectrum disorders

Zakani, M., Nigritinou, M., Ponleitner, M., Takai, Y., Hofmann, D., Hillebrand, S., Höftberger, R., Bauer, J., Lasztóczi, B., Misu, T., et al. (2023) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12893 · Cited by 6 · see citing works

Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus

Anesten, F., Mishra, D., Gasull, A. D., Engström, L., Bellman, J., Pálsdóttir, V., Zhang, F., Trapp, S., Skibicka, K. P., POUTANEN, M. H., et al. (2019) · Neuroendocrinology · doi:10.1159/000499693 · Cited by 6 · see citing works

Therapeutic effect of the NMDA antagonist MK-801 on low-level laser induced retinal injury

Yan, W., Wu, J., Chen, P., Dou, J., Pan, C. Y., Mu, Y., & Lu, J. M. (2009) · Laser Physics · doi:10.1134/s1054660x09030232 · Cited by 6 · see citing works

Neuronal hyperexcitability in dystrophin-deficient mdx hippocampal neurons: the importance of interleukin-6 and GABAergic regulation

Stephenson, K. A., Xiao, Q., Vaughan, M., Peters, P., Denley, C., O’Meara, S., Sheehan, C., Rae, M. G., & O’Malley, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-00880-z · Cited by 5 · see citing works

Upregulation of Excitatory Amino Acid Transporters by Coexpression of Janus Kinase 3

Warsi, J., Luo, D., Elvira, B., Jilani, K., Shumilina, E. V., Hosseinzadeh, Z., & Lang, F. J. W. (2014) · The Journal of Membrane Biology · doi:10.1007/s00232-014-9695-3 · Cited by 5 · see citing works

A graph-based elastic net for variable selection and module identification for genomic data analysis

Xia, Z., Zhou, X., Chen, W., & Chang, C. (2010) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm.2010.5706591 · Cited by 4 · see citing works

A novel hybrid protein promotes Aβ clearance and reduces inflammatory response through MerTKPreprint

Samentar, L., Salazar, A., Pan, P., Etebar, K., Choy, K., Uddin, D., Eliseeff, P., Bugayong, A. M., Garrido, J. A. M. G., Emini, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.03.467048 · Cited by 2 · see citing works

A novel network and sparsity constraint regression model for functional module identification in genomic data analysis

Xia, Z., Chen, W., Chang, C., & Zhou, X. (2013) · International Journal of Data Mining and Bioinformatics · doi:10.1504/ijdmb.2013.056081 · Cited by 2 · see citing works

URB597 modulates neuroplasticity, neuroinflammatory, and Nrf2/HO-1 signaling pathways in the hippocampus and prefrontal cortex of male and female rats in a stress-induced model of depression

Janković, M., Spasojević, N., Ferizović, H., Stefanović, B., Virijević, K., & Dronjak, S. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114893 · Cited by 2 · see citing works

Role of Calcium in Inflammation: Relevance to Alzheimer's Disease

Quadros, A. (2007) · doi:10.25148/etd.fi10022540 · Cited by 2 · see citing works

The Use of Nutraceutical and Pharmacological Strategies in Murine Models of Autism Spectrum Disorder

Bonetti, M., Borsani, E., & Bonomini, F. (2024) · Cells · doi:10.3390/cells13242036 · Cited by 1 · see citing works

Integrated bioinformatics analysis of shared biomarkers and mechanisms in united airway allergic disease and Alzheimer's disease

Chen, K., Huang, Y., Bao, Q., Gao, Y., Zhao, X., Shi, Y., Cheng, X., Ye, Z., & Teng, Y. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102244 · Cited by 1 · see citing works

Effect of Interleukin-6 on Long-Term Potentiation Induction and Development in Rat Hippocampal Slices

Kudryashova, I. V. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025060067 · Cited by 1 · see citing works

Inflammation and Neuronal Susceptibility to Excitotoxic Cell Death

Malva, J., & Bernardino, L. (2007) · Springer eBooks · doi:10.1007/978-0-387-70830-0_1 · Cited by 2 · see citing works

Sleep Pattern: Preventing Factors for Alzheimer Disease

Khorgami, Z., & Sugaya, K. (2015) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2015/19333 · Cited by 1 · see citing works

Dysregulation of NF-kB and JAK2/STAT3 signaling in the hippocampus of female WKY strain, a genetic animal model of depression

Stefanović, B., Virijević, K., Spasojević, N., Ferizović, H., Janković, M., Vasiljevic, P. J., & Dronjak, S. (2023) · Kragujevac Journal of Science · doi:10.5937/kgjsci2345149s · Cited by 1 · see citing works

Type 2 diabetes mellitus, drug addiction, bipolar disorder and epilepsy display overlapping aetiopathogenic mechanisms: Implication for prevention and pharmacotherapy

Oriaifo, S. E. (2015) · International Research Journal of Medicine and Medical Sciences · doi:10.14303/jmms.2015.116 · Cited by 1 · see citing works

Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer’s Disease and Their Diagnostic and Therapeutic Implications

Rojo, L. E., Fernández, J. A., Jiménez, J. M., Maccioni, A. A., Sekler, A., Kuljiš, R. O., & Maccioni, R. B. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_11 · Cited by 1 · see citing works

Astrocyte-derived soluble factors promoting neuronal differentiation of adult neural progenitor cells

Oh, J. (2010) · doi:10.31274/etd-180810-2970

IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice

Anesten, F. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy – mechanisms, challenges, and emerging therapeutics

Khalid, N., Shafin, N., Long, I., Hasim, H., & Ismail, C. A. N. (2026) · World Journal of Diabetes · doi:10.4239/wjd.v17.i1.110108

Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

Quintanilla, R. A., Orellana, D. I., González-Billault, C., & Maccioni, R. B. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.002 · Cited by 455 · see citing works

Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK

Wang, X., Peng, Y.-P., Lu, J., Cao, B., & Qiu, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.051 · Cited by 57 · see citing works

Interleukin-6 reduces NMDAR-mediated cytosolic Ca2+ overload and neuronal death via JAK/CaN signaling

Ma, S.-H., Zhuang, Q., Shen, W., Peng, Y.-P., & Qiu, Y. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.06.006 · Cited by 27 · see citing works

Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons

Hüll, M., Eistetter, J., Fiebich, B. L., & Bauer, J. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)01003-9 · Cited by 8 · see citing works

Neuroprotection of Interleukin-6 Against NMDA-Induced Apoptosis and Its Signal-Transduction Mechanisms

Liu, Z., Qiu, Y.-H., Li, B., Ma, S.-H., & Peng, Y.-P. (2011) · Neurotoxicity research · doi:10.1007/s12640-010-9215-x · Cited by 41 · see citing works