Strategies to Measure and Improve Patient Adherence in Clinical Trials
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Although the many types of monitoring methods have limitations, they can inform the interpretation of the trial result.
“Although the many types of monitoring methods have limitations,243 they can inform the interpretation of the trial result.”
From SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials (2025) · cites this paper as [243]
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“63).([17]) This article will provide an overview of patient adherence with drugs in the clinical trial setting including factors that affect patient adherence, methods to monitor adherence and strategies to minimize the barriers to adherence, including the use of newer technologies.”
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SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251 · see citing works
SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials
Hróbjartsson, A., Boutron, I., Hopewell, S., Moher, D., Schulz, K. F., Collins, G. S., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081660 · Cited by 171 · see citing works
- Authors
- Matsui, D.
- Affiliations
- Western University (CA)
- Corresponding author
- Matsui, Doreen
- Venue
- Pharmaceutical Medicine
- Published
- 2009-10
- Volume
- 23
- Issue
- 5-6
- Pages
- 289-297
- ISSN
- 0265-0673 (ISSN-L)
- 1178-2595
- 1179-1993
- OpenAlex
- W1984883552
- Cited by
- 40
- References
- 78
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- medication adherence, clinical trial compliance, adherence measurement, pill count, self-report, run-in period, fixed-dose combination, smart pillbox, text messaging, dosing frequency, patient expectations, barriers to adherence
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