Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis
Open accessAbstract
Background Adaptive aerosol delivery (AAD) nebuliser devices can reduce treatment times whilst enabling adherence to be monitored using inbuilt data logs. Using one such device, we have monitored nebulised antibiotic adherence in children with Cystic Fibrosis (CF).Methods In CF children infected with Pseudomonas aeruginosa, downloaded data from an AAD device was used to calculate morning, evening and overall monthly adherence to antibiotic therapy over a year.Results Overall monthly adherence to nebulised antibiotic therapy in 28 children was maintained between 60 and 70% over the year. Considerable variation in adherence, both between and within patients, was evident (Mean [SD] coefficient of variation, 37[44]%). Evening adherence (75[37]%) was better than morning adherence (58[34]%: p=0.012). Treatment regimens were changed in 8/28 patients based on adherence data.Conclusions Routine adherence monitoring can be implemented in an outpatient setting. Using this type of information it is possible to identify which aspects of treatment can be improved and to work together with families to individualize treatments.
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Trials using objective recorded measures suggest that adherence to inhaled therapies in people with CF is around 65% to 67% in children or adolescents.
“and 65% to 67% in children or adolescents (Ball 2013;McNamara 2009).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as McNamara 2009
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- Authors
- McNamara, P. S., McCormack, P., McDonald, A. J., Heaf, L., & Southern, K. W.
- Affiliations
- Alder Hey Children's NHS Foundation Trust (GB)
- Corresponding author
- McNamara, Paul S.
- Venue
- Journal of Cystic Fibrosis
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 8
- Issue
- 4
- Pages
- 258-263
- ISSN
- 1569-1993 (ISSN-L)
- OpenAlex
- W2152725098
- Cited by
- 72
- References
- 17
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 4
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cystic Fibrosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- medication adherence, nebulized antibiotics, Pseudomonas aeruginosa, children, adherence monitoring, outpatient care, personalized treatment
- MeSH terms
- Administration, Inhalation, Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Colistin, Cystic Fibrosis, Humans, Nebulizers and Vaporizers, Pseudomonas aeruginosa, Pseudomonas Infections, Retrospective Studies, Drug Monitoring, Medication Adherence
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