The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

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The p53 pathway: positive and negative feedback loops

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Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

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The MDM2 gene amplification database

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The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor

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MDM2 — master regulator of the p53 tumor suppressor protein

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Nucleo‐cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

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The MDM2 RING-finger domain is required to promote p53 nuclear export

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

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MDM2 suppresses p73 function without promoting p73 degradation

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Transcriptional Repression by RING Finger Protein TIF1 That Interacts with the KRAB Repressor Domain of KOX1

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

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Two B or not two B? overview of the rapidly expanding B-box family of proteins

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Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

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Untitled work

(2003) · PubMed · Cited by 147

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

Chen, L., Marechal, V., Moreau, J., Levine, A. J., & Chen, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22966 · Cited by 121

Identification of a CK2 phosphorylation site in mdm2.

Götz, C., Kartarius, S., Scholtes, P., Nastainczyk, W., & Montenarh, M. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00882.x · Cited by 39