Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

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p53 Mutations in Human Cancers

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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

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Human ICE/CED-3 Protease Nomenclature

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

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The p53-mdm-2 autoregulatory feedback loop.

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Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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mdm2 expression is induced by wild type p53 activity.

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

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p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

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Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

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p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

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Mapping of the p53 and mdm-2 Interaction Domains

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MDMX: a novel p53‐binding protein with some functional properties of MDM2.

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The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.

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Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

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Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53.Preprint

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Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

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Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.Preprint

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Untitled work

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Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

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Genetic determinants of p53-induced apoptosis and growth arrest.Preprint

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Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

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mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

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DNA‐dependent protein kinase catalytic subunit: a target for an ICE‐like protease in apoptosis.

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IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

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The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes

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Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

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Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

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Specific cleavage of the retinoblastoma protein by an ICE‐like protease in apoptosis.

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Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.

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Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

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Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

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D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

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Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

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Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

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The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

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Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif

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The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

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Amplification of MDM2 Inhibits MyoD-Mediated Myogenesis

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N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation.

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Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis

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Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

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Caspase structure, proteolytic substrates, and function during apoptotic cell death

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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Proteases to die forPreprint

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Many cuts to ruin: a comprehensive update of caspase substrates

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The N‐end rule pathway and regulation by proteolysis

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MDM2 — master regulator of the p53 tumor suppressor protein

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Functions of the MDM2 oncoprotein

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Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

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Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems

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THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

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MDM2 interacts with MDMX through their RING finger domains

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Caspase Pathways, Neuronal Apoptosis, and CNS Injury

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Critical loss of CBP/p300 histone acetylase activity by caspase‐6 during neurodegeneration

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Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells.

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MDM2 promotes ubiquitination and degradation of MDMX

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Histopathological Evaluation of Apoptosis in Cancer

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Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

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MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

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Mdm2: The Ups and Downs

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Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.

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Regulation of p53 stability and activity in response to genotoxic stress

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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

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Caspase-3 and Caspase-Activated Deoxyribonuclease Are Associated with Testicular Germ Cell Apoptosis Resulting from Reduced Intratesticular Testosterone

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Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

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Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

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N-Myc Down-regulated Gene 1 Modulates the Response of Term Human Trophoblasts to Hypoxic Injury

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A Dual Role of Cyclin E in Cell Proliferation and Apotosis May Provide a Target for Cancer Therapy

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Micromanaging aerobic respiration and glycolysis in cancer cells

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