Selenium: an insulin mimetic

Stapleton, S. R.

doi:10.1007/pl00000669

Cited by 249Selenium in Biological SystemsMetabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Selenium: an insulin mimetic

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Stapleton, S. R.·2000·Cellular and Molecular Life Sciences

DOI 10.1007/pl00000669PMC PMC11147121

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Abstract

Insulin or agents that can mimic its action (insulin-mimetics) are necessary to promote the entry of glucose into tissues where the glucose can either be converted into energy or stored for later use. In recent years, selenium has been shown to mediate a number of insulin-like actions both in vivo and in vitro. These insulin-like actions include stimulating glucose uptake and regulating metabolic processes such as glycolysis, gluconeogenesis, fatty acid synthesis and the pentose phosphate pathway. The mechanism by which selenium is capable of mimicking insulin is not clear; however, reports indicate that selenium does activate key proteins involved in the insulin-signal cascade. Various proteins in the insulin-signal cascade have been shown to be necessary for different insulin-regulated events, and presumably data will be forthcoming soon that illustrate this similarly for selenium. This review compares the action of selenium to that of insulin and discusses the available evidence in support of selenium as an insulin-mimetic.

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Selenate is an efficient insulin-mimetic and reduces glucose level in streptozotocin-induced diabetes in laboratory animals.
“Experimental evidence supports selenate as an efficient insulin-mimetic (Stapleton 2000). For example, selenate has been shown to reduce the glucose level in streptozotocin-induced diabetes in laboratory animals.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Stapleton 2000

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Authors: Stapleton, S. R.
Affiliations: Western Michigan University (US)
Corresponding author: Stapleton, S. R.
ORCID: Stapleton, S. R.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 57
Issue: 13
Pages: 1874-1879
ISSN: 1420-682X (ISSN-L)
DOI: 10.1007/pl00000669
PMC: PMC11147121
OpenAlex: W2021051803
Cited by: 249
References: 41
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 14 · 2021: 14 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 11 · 2016: 11 · 2015: 11 · 2014: 18 · 2013: 12 · 2012: 14
FWCI: 2.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: selenium, insulin mimetics, insulin-like activity, glucose uptake, glycolysis, gluconeogenesis, fatty acid synthesis, pentose phosphate pathway, glucose metabolism
MeSH terms: Animals, Diabetes Mellitus, Glucose, Humans, Hypoglycemic Agents, Insulin, Selenium, Vanadates, Signal Transduction, Selenium Compounds, Molecular Mimicry, Selenic Acid

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Selenium: an insulin mimetic

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