The use of nitric oxide donors in pharmacological studies

The reaction of NO with superoxide

Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238

Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

Maragos, C. M., Morley, D., Wink, D. A., Dunams, T. M., Saavedra, J. E., Hoffman, A., Bove, A. A., Isaac, L., Hrabie, J. A., & Keefer, L. K. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00115a013 · Cited by 722

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

Hogg, N., Darley-Usmar, V. M., Wilson, M. T., & Moncada, S. (1992) · Biochemical Journal · doi:10.1042/bj2810419 · Cited by 698

Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins

Doyle, M. P., & Hoekstra, J. W. (1981) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80291-3 · Cited by 643

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

Gaston, B., Reilly, J., Drazen, J. M., Fackler, J., Ramdev, P., Arnelle, D., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10957 · Cited by 623

NO+, NO, and NO- donation by S-nitrosothiols-implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation

Arnelle, D. R., & Stamler, J. S. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1231 · Cited by 604 · cited 2×

The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators: Appropriate Choice of Exogenous NO Donors and Aspects of Preparation and Handling of Aqueous NO Solutions

Feelisch, M. (1991) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199117003-00006 · Cited by 479

Nitric oxide generation from nitroprusside by vascular tissue

Bates, J. N., Baker, M. T., Guerra, R., & Harrison, D. G. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90406-u · Cited by 461

The Simultaneous Generation of Superoxide and Nitric Oxide Can Initiate Lipid Peroxidation in Human Low Density Lipoprotein

Darley-usmar, V. M., Hogg, N., O'leary, V. J., Wilson, M. T., & Moncada, S. (1992) · Free Radical Research Communications · doi:10.3109/10715769209061085 · Cited by 456

Some observations concerning the S-nitroso and S-phenylsulphonyl derivatives of L-cysteine and glutathione

Hart, T. W. (1985) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)98368-0 · Cited by 398

On the Mechanism of NO Release from Sydnonimines

Feelisch, M., Ostrowski, J., & Noack, E. (1989) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198906152-00004 · Cited by 305

The nitrovasodilators. New ideas about old drugs.

Harrison, D. G., & Bates, J. N. (1993) · Circulation · doi:10.1161/01.cir.87.5.1461 · Cited by 301

An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite

Field, L., Dilts, R. V., Ravichandran, R., Lenhert, P. G., & Carnahan, G. E. (1978) · Journal of the Chemical Society, Chemical Communications · doi:10.1039/c39780000249 · Cited by 290

Targeting Nitric Oxide (NO) Delivery in Vivo. Design of a Liver-Selective NO Donor Prodrug That Blocks Tumor Necrosis Factor-α-Induced Apoptosis and Toxicity in the Liver

Saavedra, J. E., Billiar, T. R., Williams, D. L., Kim, Y.-M., Watkins, S. C., & Keefer, L. K. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm9701031 · Cited by 273

Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle.

Kowaluk, E. A., Seth, P., & Fung, H. L. (1992) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10935-x · Cited by 255

Biological activity of S-nitrosothiols: the role of nitric oxide.

Mathews, W. R., & Kerr, S. W. (1993) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39447-4 · Cited by 252

Organic nitrate esters: clinical use and mechanisms of actions.

Ahlner, J., Andersson, R. G., Torfgård, K., & Axelsson, K. L. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06667-0 · Cited by 243

Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.

Kowaluk, E. A., & Fung, H. L. (1990) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23068-3 · Cited by 241

Complexes of Nitric Oxide with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide: Hemodynamic Effect in the Rabbit

Diodati, J. G., Quyyumi, A. A., & Keefer, L. K. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199308000-00018 · Cited by 228

Kinetics of nitric oxide autoxidation in aqueous solution.

Kharitonov, V. G., Sundquist, A. R., & Sharma, V. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37543-9 · Cited by 224

Nitric Oxide (NO) Donor Molecules: Effect of NO Release Rate on Vascular Smooth Muscle Cell Proliferation In Vitro

Mooradian, D. L., Hutsell, T. C., & Keefer, L. K. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199504000-00023 · Cited by 221

S-Nitrosothiols and the Bioregulatory Actions of Nitrogen Oxides Through Reactions with Thiol Groups

Stamler, J. S. (1995) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-79130-7_4 · Cited by 207

Identification of Cu+ as the effective reagent in nitric oxide formation from S-nitrosothiols (RSNO)

Dicks, A. P., Swift, H. R., Williams, D. L. H., Butler, A. R., Al-Sa'doni, H. H., & Cox, B. G. (1996) · Journal of the Chemical Society, Perkin Transactions 2 · doi:10.1039/p29960000481 · Cited by 195

Decomposition ofS-Nitrosoglutathione in the Presence of Copper Ions and Glutathione

Gorren, A. C. F., Schrammel, A., Schmidt, K., & Mayer, B. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0247 · Cited by 180

Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells

Feelisch, M., & Kelm, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81290-2 · Cited by 159

Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion.

Wolin, M. S., Cherry, P. D., Rodenburg, J. M., Messina, E. J., & Kaley, G. (1990) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12689-x · Cited by 158

Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro.

Gaston, B. M., Drazen, J. M., Jansen, A., Sugarbaker, D. A., Loscalzo, J., Richards, W., & Stamler, J. S. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38951-2 · Cited by 151

Metal ion catalysis in nitrosothiol (RSNO) decomposition

McAninly, J., Williams, D. L. H., Askew, S. C., Butler, A. R., & Russell, C. (1993) · Journal of the Chemical Society, Chemical Communications · doi:10.1039/c39930001758 · Cited by 150 · cited 2×

Therapeutic Effects of Imidazolineoxyl N-Oxide Against Endotoxin Shock through Its Direct Nitric Oxide-Scavenging Activity

Yoshida, M., Akaike, T., Wada, Y., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2018 · Cited by 140

Mechanisms of action of nitrates

Torfg�rd, K. E., & Ahlner, J. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877117 · Cited by 133

Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.

Maragos, C. M., Wang, J., Hrabie, J. A., Oppenheim, J. J., & Keefer, L. K. (1993) · PubMed · Cited by 132

Biotransformation of organic nitrates and vascular smooth muscle cell function

Bennett, B. M., McDonald, B. J., Nigam, R., & Simon, W. C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90319-0 · Cited by 130

Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators.

Morley, D. L., & Keefer, L. K. (1993) · PubMed · Cited by 122

Nitric oxide and peroxynitrite

Beckman, J. S. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90271-u · Cited by 115

Copper chelation‐induced reduction of the biological activity of S‐nitrosothiols

Gordge, M. P., Meyer, D. J., Hothersall, J. S., Neild, G. H., Payne, N. N., & Noronha-Dutra, A. A. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13317.x · Cited by 105

Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines

Bohn, H., & Schönafinger, K. (1989) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198906152-00003 · Cited by 101

Measurement and Modeling of Nitric Oxide Release Rates for Nitric Oxide Donors

Ramamurthi, A., & Lewis, R. S. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960183w · Cited by 94

Release of nitric oxide from donors with known half-life: a mathematical model for calculating nitric oxide concentrations in aerobic solutions

Schmidt, K., Desch, W., Klatt, P., Kukovetz, W. R., & Mayer, B. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00004969 · Cited by 87

Day 1 Sunday, 29 August 1993

Feelisch, M. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.suppl.1 · Cited by 86

Secondary amine/nitric oxide complex ions, R2N[N(O)NO]-. O-Functionalization chemistry

Saavedra, J. E., Dunams, T. M., Flippen-Anderson, J. L., & Keefer, L. K. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00049a017 · Cited by 84

Biochemical and pharmacological interactions between nitroglycerin and thiols

Chong, S., & Ho-leung, F. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90456-f · Cited by 79

Cytochrome P-450 mediates bioactivation of organic nitrates.

Schröder, H. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10750-7 · Cited by 79

Molecular Aspects Underlying the Vasodilator Action of Molsidomine

Noack, E., & Feelisch, M. (1989) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198906152-00002 · Cited by 76

Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.

Boesgaard, S., Aldershvile, J., Poulsen, H. E., Loft, S. H., Anderson, M. E., & Meister, A. (1994) · Circulation Research · doi:10.1161/01.res.74.1.115 · Cited by 73

LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation

M�lsch, A., L�ckhoff, A., Pohl, U., Busse, R., & Bassenge, E. (1989) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169217 · Cited by 72

Explanation of the discrepancy between the degree of organic nitrate decomposition, nitrite formation and guanylate cyclase stimulation

Feelisch, M., Noack, E., & Schröder, H. (1988) · European Heart Journal · doi:10.1093/eurheartj/9.suppl_a.57 · Cited by 72

Dissociation of cysteine and glutathione levels from nitroglycerin-induced relaxation

Gruetter, C. A., & Lemke, S. M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90116-5 · Cited by 67

Reductive metabolism of nitroprusside in rat hepatocytes and human erythrocytes

Rao, D. N. R., Elguindi, S., & O'Brien, P. J. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90005-4 · Cited by 67

Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450

McDonald, B. J., & Bennett, B. M. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90403-j · Cited by 60

Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells

Seth, P. K., & Fung, H. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90115-d · Cited by 53

Conversion of nitroglycerin to nitric oxide in microsomes of the bovine coronary artery smooth muscle is not primarily mediated by glutathione-S-transferases.

Chung, S., Chong, S., Seth, P. K., Jung, C., & Fung, H. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11346-3 · Cited by 53

The reaction between organic nitrates and sulfhydryl compounds. A possible model system for the activation of organic nitrates.

Yeates, R. A., Laufen, H., & Leitold, M. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14198-9 · Cited by 53

Inhibition of the biotransformation and pharmacological actions of glyceryl trinitrate by the flavoprotein inhibitor, diphenyleneiodonium sulfate.

McGuire, J. J., Anderson, D. J., & Bennett, B. M. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23818-6 · Cited by 45

Bioactivation of Nitroprusside by Porcine Endothelial Cells

Rochelle, L. G., Kruszyna, H. G., Kruszyna, R., Barchowsky, A., Wilcox, D. E., & Smith, R. P. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1189 · Cited by 37

CAS 936, a Novel Sydnonimine with Direct Vasodilating and Nitric Oxide-Donating Properties

Bohn, H., Beyerle, R., Martorana, P. A., & Schönafinger, K. (1991) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199110000-00007 · Cited by 27

Lack of evidence for the involvement of cytochrome P-450 or other hemoproteins in metabolic activation of glyceryl trinitrate in rabbit aorta.

Liu, Z., Brien, J. F., Marks, G. S., McLaughlin, B. E., & Nakatsu, K. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10162-6 · Cited by 26

Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels

Wheatley, R. M., Dockery, S., Kurz, M. A., et al. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.1.h291 · Cited by 25

Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase

Kenkare, S. R., Han, C., & Benet, L. Z. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)00415-3 · Cited by 23

3-Morpholino-Sydnonimine-Induced Suppression of Human Neutrophil Degranulation is Not Mediated by Cyclic GMP, Nitric Oxide or Peroxynitrite: Inhibition of the Increase in Intracellular Free Calcium Concentration by N-Morpholino- iminoacetonitrile, a Metabolite of 3-Morpholino-Sydnonimine

Kankaanranta, H., Knowles, R. G., Vuorinen, P., Kosonen, O., Holm, P., & Moilanen, E. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.5.882 · Cited by 22

Enzymic and nonenzymic release of NO accounts for the vasodilator activity of the metabolites of CAS 936, a novel long-acting sydnonimine derivative

M�lsch, A., Hecker, M., Mordvintcev, P. I., Vanin, A. F., & Busse, R. (1993) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00168778 · Cited by 20

Persistent Inhibition of Platelets During Continuous Nitroglycerin Therapy Despite Hemodynamic Tolerance

́bert, D. H., Xiang, J.-X., & Lam, J. Y. T. (1997) · Circulation · doi:10.1161/01.cir.95.5.1308 · Cited by 18

Mutagenicity of thionitrites in the ames test

Carter, M. H., & Josephy, P. D. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90674-x · Cited by 17

Glutathione S-transferase μ polymorphism does not explain variation in nitroglycerin responsiveness

Haefeli, W. E., Srivastava, N., Kelsey, K. T., Wiencke, J. K., Hoffman, B. B., & Blaschke, T. F. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.52 · Cited by 16

Nitric oxide synthases: structure, function and inhibition

ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110

Nitric oxide donors: chemical activities and biological applications

Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337

Nitric Oxide Signaling in Plants

Shapiro, A. D. (2005) · Vitamins & Hormones · doi:10.1016/s0083-6729(05)72010-0 · Cited by 318

Oxidative stress and beta-cell dysfunction

Drews, G., Krippeit-Drews, P., & Düfer, M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0862-9 · Cited by 315

The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

Foresti, R., & Motterlini, R. (1999) · Free Radical Research · doi:10.1080/10715769900301031 · Cited by 274