The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases
Open accessAbstract
Zinc is required for multiple cellular tasks, and especially the immune system depends on a sufficient availability of this essential trace element. During the last decades, many studies attempted to affect the outcome of various diseases by zinc supplementation. These efforts either aimed at supporting immunity by zinc administration or at correcting a loss of zinc secondary to the disease to restore the zinc-dependent functions of the immune system. This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. In contrast, the results for the common cold and malaria are still not conclusive, and zinc was ineffective in most vaccination and rheumatoid arthritis studies. For AIDS and type 1 diabetes, zinc supplementation may even be a risk factor for increased mortality or deterioration of the glucose metabolism, respectively. In these cases, zinc supplementation should be used with care and limited to clearly zinc-deficient individuals.
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Cites
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Antioxidant effect of zinc in humans
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Reprogramming of the immune system during zinc deficiency
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Metadata
- Authors
- Overbeck, S., Rink, L., & Haase, H.
- Venue
- Archivum Immunologiae et Therapiae Experimentalis
- Publisher
- Walter de Gruyter GmbH
- Published
- 2008-02
- Volume
- 56
- Issue
- 1
- Pages
- 15-30
- ISSN
- 0004-069X (ISSN-L)
- 1661-4917
- OpenAlex
- W2033568629
- Cited by
- 211
- References
- 8
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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