The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
Open accessAbstract
Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.
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“In the CNS, this plasticity is modulated by neurotrophic factors, which promote neuronal growth, survival, and regeneration, and are commonly referred to as neurotrophins (Xiao and Le, 2016).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Xiao and Le, 2016
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3 retracted
Jain, V., Baitharu, I., Prasad, D. N., & Ilavazhagan, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062235 · Cited by 86
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RetractedLiu, W., Wang, X.-J., Lü, G., Li, B., Wang, G., & Chen, S. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-45 · Cited by 2
RetractedShrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Neurotrophins: Roles in Neuronal Development and Function
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GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
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Neurotrophin-regulated signalling pathways
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The GDNF family: Signalling, biological functions and therapeutic value
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Metadata
- Authors
- Xiao, N., & Le, Q.-T.
- Affiliations
- University of the Pacific (US)
- Stanford Medicine (US)
- Corresponding author
- Xiao, Nan
- Venue
- Archivum Immunologiae et Therapiae Experimentalis
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-11-26
- Volume
- 64
- Issue
- 2
- Pages
- 89-99
- ISSN
- 0004-069X (ISSN-L)
- 1661-4917
- PMC
- PMC4805470
- OpenAlex
- W2180157788
- Cited by
- 93
- References
- 212
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 15 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 5 · 2016: 2
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archivum Immunologiae et Therapiae Experimentalis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarly Commons (University of the Pacific) (submittedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE025227)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- neurotrophic factors, tissue regeneration, neurodegenerative diseases, neuronal survival, neuronal regeneration, non-neuronal tissues, anti-inflammation, cell proliferation, cell differentiation, growth factors, clinical application
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Differentiation, Cell Survival, Humans, Nerve Growth Factors, Neurons, Neurodegenerative Diseases, Guided Tissue Regeneration, Cell Proliferation
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